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Gene: FAM83A |
Gene summary for FAM83A |
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Gene information | Species | Human | Gene symbol | FAM83A | Gene ID | 84985 |
Gene name | family with sequence similarity 83 member A | |
Gene Alias | BJ-TSA-9 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q86UY5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84985 | FAM83A | CA_HPV_2 | Human | Cervix | CC | 2.06e-04 | 2.06e-01 | 0.0391 |
84985 | FAM83A | CCI_1 | Human | Cervix | CC | 1.40e-15 | 1.29e+00 | 0.528 |
84985 | FAM83A | CCI_3 | Human | Cervix | CC | 1.15e-04 | 8.73e-01 | 0.516 |
84985 | FAM83A | Tumor | Human | Cervix | CC | 3.58e-28 | 6.52e-01 | 0.1241 |
84985 | FAM83A | sample3 | Human | Cervix | CC | 1.59e-60 | 9.11e-01 | 0.1387 |
84985 | FAM83A | H2 | Human | Cervix | HSIL_HPV | 1.70e-08 | 4.43e-01 | 0.0632 |
84985 | FAM83A | L1 | Human | Cervix | CC | 7.42e-04 | 4.33e-01 | 0.0802 |
84985 | FAM83A | T1 | Human | Cervix | CC | 3.81e-02 | 2.54e-01 | 0.0918 |
84985 | FAM83A | T3 | Human | Cervix | CC | 6.32e-53 | 8.75e-01 | 0.1389 |
84985 | FAM83A | LZE20T | Human | Esophagus | ESCC | 6.34e-29 | 1.37e+00 | 0.0662 |
84985 | FAM83A | P1T-E | Human | Esophagus | ESCC | 1.69e-03 | 3.51e-01 | 0.0875 |
84985 | FAM83A | P8T-E | Human | Esophagus | ESCC | 2.16e-15 | 5.35e-01 | 0.0889 |
84985 | FAM83A | P11T-E | Human | Esophagus | ESCC | 9.69e-04 | 7.10e-01 | 0.1426 |
84985 | FAM83A | P17T-E | Human | Esophagus | ESCC | 3.93e-09 | 1.49e+00 | 0.1278 |
84985 | FAM83A | P19T-E | Human | Esophagus | ESCC | 1.03e-03 | 1.12e+00 | 0.1662 |
84985 | FAM83A | P20T-E | Human | Esophagus | ESCC | 3.00e-30 | 7.86e-01 | 0.1124 |
84985 | FAM83A | P21T-E | Human | Esophagus | ESCC | 3.41e-12 | 5.35e-01 | 0.1617 |
84985 | FAM83A | P22T-E | Human | Esophagus | ESCC | 1.85e-03 | 1.67e-01 | 0.1236 |
84985 | FAM83A | P23T-E | Human | Esophagus | ESCC | 5.48e-04 | 3.72e-01 | 0.108 |
84985 | FAM83A | P27T-E | Human | Esophagus | ESCC | 2.42e-06 | 3.92e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
GO:003812718 | Esophagus | ESCC | ERBB signaling pathway | 82/8552 | 121/18723 | 7.23e-07 | 9.40e-06 | 82 |
GO:000717318 | Esophagus | ESCC | epidermal growth factor receptor signaling pathway | 73/8552 | 108/18723 | 3.36e-06 | 3.73e-05 | 73 |
GO:003812715 | Oral cavity | OSCC | ERBB signaling pathway | 76/7305 | 121/18723 | 9.59e-08 | 1.66e-06 | 76 |
GO:000717315 | Oral cavity | OSCC | epidermal growth factor receptor signaling pathway | 67/7305 | 108/18723 | 1.04e-06 | 1.40e-05 | 67 |
GO:003812716 | Oral cavity | LP | ERBB signaling pathway | 42/4623 | 121/18723 | 8.53e-03 | 4.61e-02 | 42 |
GO:0007173110 | Skin | SCCIS | epidermal growth factor receptor signaling pathway | 18/919 | 108/18723 | 4.95e-06 | 2.05e-04 | 18 |
GO:0038127110 | Skin | SCCIS | ERBB signaling pathway | 19/919 | 121/18723 | 6.72e-06 | 2.64e-04 | 19 |
GO:003812724 | Skin | cSCC | ERBB signaling pathway | 55/4864 | 121/18723 | 2.77e-06 | 4.38e-05 | 55 |
GO:000717323 | Skin | cSCC | epidermal growth factor receptor signaling pathway | 48/4864 | 108/18723 | 2.42e-05 | 2.76e-04 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83A | SNV | Missense_Mutation | c.77G>T | p.Arg26Met | p.R26M | Q86UY5 | protein_coding | deleterious(0.01) | possibly_damaging(0.87) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM83A | SNV | Missense_Mutation | novel | c.236N>T | p.Pro79Leu | p.P79L | Q86UY5 | protein_coding | tolerated(0.63) | benign(0.003) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83A | SNV | Missense_Mutation | novel | c.991T>C | p.Ser331Pro | p.S331P | Q86UY5 | protein_coding | tolerated(0.43) | benign(0) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83A | SNV | Missense_Mutation | novel | c.238N>A | p.Cys80Ser | p.C80S | Q86UY5 | protein_coding | tolerated(0.42) | benign(0.007) | TCGA-78-7161-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FAM83A | SNV | Missense_Mutation | c.585N>T | p.Gln195His | p.Q195H | Q86UY5 | protein_coding | tolerated(0.54) | benign(0.018) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
FAM83A | SNV | Missense_Mutation | novel | c.487N>C | p.Val163Leu | p.V163L | Q86UY5 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
FAM83A | SNV | Missense_Mutation | novel | c.718A>T | p.Ile240Phe | p.I240F | Q86UY5 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM83A | SNV | Missense_Mutation | novel | c.22N>A | p.Gly8Ser | p.G8S | Q86UY5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM83A | SNV | Missense_Mutation | c.952N>A | p.Arg318Ser | p.R318S | Q86UY5 | protein_coding | tolerated(0.99) | benign(0) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM83A | insertion | In_Frame_Ins | novel | c.981_982insGACCGCACGTCCTCCAACCCCTTCAGCGGCCGCTCGGCAGGCAGC | p.Asp328_Ser342dup | p.D328_S342dup | Q86UY5 | protein_coding | TCGA-75-7027-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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