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Gene: FAM71D |
Gene summary for FAM71D |
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Gene information | Species | Human | Gene symbol | FAM71D | Gene ID | 161142 |
Gene name | family with sequence similarity 71 member D | |
Gene Alias | C14orf54 | |
Cytomap | 14q23.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8N9W8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
161142 | FAM71D | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.35e-08 | 2.05e-01 | -0.1808 |
161142 | FAM71D | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-03 | 1.40e-01 | -0.0811 |
161142 | FAM71D | HTA11_78_2000001011 | Human | Colorectum | AD | 6.77e-08 | 2.17e-01 | -0.1088 |
161142 | FAM71D | HTA11_347_2000001011 | Human | Colorectum | AD | 3.31e-13 | 2.47e-01 | -0.1954 |
161142 | FAM71D | HTA11_411_2000001011 | Human | Colorectum | SER | 4.21e-04 | 3.57e-01 | -0.2602 |
161142 | FAM71D | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-03 | 1.58e-01 | -0.1207 |
161142 | FAM71D | HTA11_696_2000001011 | Human | Colorectum | AD | 9.55e-09 | 1.75e-01 | -0.1464 |
161142 | FAM71D | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 1.66e-01 | -0.1001 |
161142 | FAM71D | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.70e-11 | 3.66e-01 | -0.059 |
161142 | FAM71D | HTA11_546_2000001011 | Human | Colorectum | AD | 4.47e-03 | 1.57e-01 | -0.0842 |
161142 | FAM71D | HTA11_866_3004761011 | Human | Colorectum | AD | 3.35e-04 | 1.49e-01 | 0.096 |
161142 | FAM71D | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-06 | 1.59e-01 | 0.0674 |
161142 | FAM71D | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.29e-03 | 2.63e-01 | 0.0112 |
161142 | FAM71D | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.24e-08 | 2.89e-01 | 0.0588 |
161142 | FAM71D | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.92e-04 | 9.83e-02 | 0.294 |
161142 | FAM71D | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.44e-12 | 2.61e-01 | 0.3859 |
161142 | FAM71D | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.74e-02 | 2.02e-01 | 0.2585 |
161142 | FAM71D | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.25e-05 | 1.23e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM71D | SNV | Missense_Mutation | novel | c.540N>C | p.Lys180Asn | p.K180N | Q8N9W8 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM71D | SNV | Missense_Mutation | novel | c.1141N>T | p.Leu381Phe | p.L381F | Q8N9W8 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.796) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
FAM71D | SNV | Missense_Mutation | novel | c.298N>G | p.Thr100Ala | p.T100A | Q8N9W8 | protein_coding | tolerated(0.47) | benign(0.024) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM71D | SNV | Missense_Mutation | c.411N>T | p.Met137Ile | p.M137I | Q8N9W8 | protein_coding | deleterious(0.02) | benign(0.294) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM71D | SNV | Missense_Mutation | novel | c.609N>T | p.Met203Ile | p.M203I | Q8N9W8 | protein_coding | deleterious(0.03) | benign(0) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FAM71D | SNV | Missense_Mutation | novel | c.1134C>A | p.Ser378Arg | p.S378R | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.462) | TCGA-44-6144-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FAM71D | SNV | Missense_Mutation | novel | c.97T>G | p.Leu33Val | p.L33V | Q8N9W8 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
FAM71D | SNV | Missense_Mutation | novel | c.704C>T | p.Pro235Leu | p.P235L | Q8N9W8 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-55-6987-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM71D | SNV | Missense_Mutation | novel | c.689N>T | p.Asp230Val | p.D230V | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | benign(0.342) | TCGA-55-8090-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM71D | SNV | Missense_Mutation | novel | c.1034G>C | p.Arg345Thr | p.R345T | Q8N9W8 | protein_coding | deleterious_low_confidence(0) | benign(0.029) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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