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Gene: FAM222A |
Gene summary for FAM222A |
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Gene information | Species | Human | Gene symbol | FAM222A | Gene ID | 84915 |
Gene name | family with sequence similarity 222 member A | |
Gene Alias | C12orf34 | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A024RBN3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84915 | FAM222A | HCC1_Meng | Human | Liver | HCC | 6.32e-03 | 1.03e-02 | 0.0246 |
84915 | FAM222A | HCC1 | Human | Liver | HCC | 3.12e-03 | 1.96e+00 | 0.5336 |
84915 | FAM222A | HCC2 | Human | Liver | HCC | 4.15e-09 | 1.85e+00 | 0.5341 |
84915 | FAM222A | S014 | Human | Liver | HCC | 4.34e-20 | 5.71e-01 | 0.2254 |
84915 | FAM222A | S015 | Human | Liver | HCC | 4.50e-13 | 4.64e-01 | 0.2375 |
84915 | FAM222A | S016 | Human | Liver | HCC | 9.35e-20 | 5.41e-01 | 0.2243 |
84915 | FAM222A | S027 | Human | Liver | HCC | 5.76e-05 | 5.78e-01 | 0.2446 |
84915 | FAM222A | S028 | Human | Liver | HCC | 8.36e-16 | 3.92e-01 | 0.2503 |
84915 | FAM222A | S029 | Human | Liver | HCC | 2.15e-13 | 4.36e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM222A | SNV | Missense_Mutation | c.647N>T | p.Ala216Val | p.A216V | Q5U5X8 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM222A | SNV | Missense_Mutation | c.596N>C | p.Ile199Thr | p.I199T | Q5U5X8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FAM222A | SNV | Missense_Mutation | novel | c.451N>A | p.Pro151Thr | p.P151T | Q5U5X8 | protein_coding | deleterious(0.03) | possibly_damaging(0.868) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
FAM222A | SNV | Missense_Mutation | rs200837548 | c.643N>A | p.Ala215Thr | p.A215T | Q5U5X8 | protein_coding | tolerated(0.16) | benign(0.039) | TCGA-DE-A0XZ-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
FAM222A | SNV | Missense_Mutation | novel | c.56C>A | p.Pro19Gln | p.P19Q | Q5U5X8 | protein_coding | deleterious(0.01) | benign(0.382) | TCGA-DJ-A2PX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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