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Gene: FAM167A |
Gene summary for FAM167A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM167A | Gene ID | 83648 |
| Gene name | family with sequence similarity 167 member A | |
| Gene Alias | C8orf13 | |
| Cytomap | 8p23.1 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96KS9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 83648 | FAM167A | male-WTA | Human | Thyroid | PTC | 1.33e-03 | -2.42e-02 | 0.1037 |
| 83648 | FAM167A | PTC07 | Human | Thyroid | PTC | 1.43e-04 | -1.34e-01 | 0.2044 |
| 83648 | FAM167A | ATC12 | Human | Thyroid | ATC | 2.23e-08 | -5.07e-02 | 0.34 |
| 83648 | FAM167A | ATC4 | Human | Thyroid | ATC | 1.49e-07 | -2.84e-02 | 0.34 |
| 83648 | FAM167A | ATC5 | Human | Thyroid | ATC | 4.82e-02 | -1.60e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM167A | deletion | Frame_Shift_Del | c.278delC | p.Pro93LeufsTer28 | p.P93Lfs*28 | Q96KS9 | protein_coding | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
| FAM167A | deletion | Frame_Shift_Del | c.234delN | p.Gln79ArgfsTer7 | p.Q79Rfs*7 | Q96KS9 | protein_coding | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
| FAM167A | SNV | Missense_Mutation | rs376899787 | c.247N>A | p.Leu83Ile | p.L83I | Q96KS9 | protein_coding | tolerated(0.29) | benign(0.04) | TCGA-DD-AAVY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
| FAM167A | SNV | Missense_Mutation | c.574N>A | p.Leu192Ile | p.L192I | Q96KS9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| FAM167A | SNV | Missense_Mutation | novel | c.232G>T | p.Gly78Trp | p.G78W | Q96KS9 | protein_coding | deleterious(0.05) | possibly_damaging(0.533) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD |
| FAM167A | SNV | Missense_Mutation | c.18N>G | p.Ile6Met | p.I6M | Q96KS9 | protein_coding | tolerated(0.18) | benign(0.035) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| FAM167A | SNV | Missense_Mutation | rs141133384 | c.226C>T | p.Arg76Cys | p.R76C | Q96KS9 | protein_coding | tolerated(0.13) | benign(0) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| FAM167A | deletion | Frame_Shift_Del | c.234delN | p.Gln79ArgfsTer7 | p.Q79Rfs*7 | Q96KS9 | protein_coding | TCGA-77-7338-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
| FAM167A | SNV | Missense_Mutation | novel | c.118G>C | p.Glu40Gln | p.E40Q | Q96KS9 | protein_coding | tolerated(0.82) | benign(0.093) | TCGA-QK-A8ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| FAM167A | SNV | Missense_Mutation | c.125N>A | p.Arg42His | p.R42H | Q96KS9 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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