![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: F12 |
Gene summary for F12 |
![]() |
Gene information | Species | Human | Gene symbol | F12 | Gene ID | 2161 |
Gene name | coagulation factor XII | |
Gene Alias | HAE3 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0002254 | UniProtAcc | P00748 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2161 | F12 | LZE4T | Human | Esophagus | ESCC | 1.33e-06 | 2.02e-01 | 0.0811 |
2161 | F12 | LZE24T | Human | Esophagus | ESCC | 3.87e-07 | 3.38e-01 | 0.0596 |
2161 | F12 | LZE21T | Human | Esophagus | ESCC | 8.73e-03 | 4.30e-01 | 0.0655 |
2161 | F12 | LZE6T | Human | Esophagus | ESCC | 2.64e-03 | 1.92e-01 | 0.0845 |
2161 | F12 | P1T-E | Human | Esophagus | ESCC | 4.64e-02 | 2.89e-01 | 0.0875 |
2161 | F12 | P2T-E | Human | Esophagus | ESCC | 1.29e-09 | 2.60e-01 | 0.1177 |
2161 | F12 | P4T-E | Human | Esophagus | ESCC | 3.08e-29 | 8.28e-01 | 0.1323 |
2161 | F12 | P5T-E | Human | Esophagus | ESCC | 1.41e-35 | 7.80e-01 | 0.1327 |
2161 | F12 | P9T-E | Human | Esophagus | ESCC | 4.63e-08 | 2.49e-01 | 0.1131 |
2161 | F12 | P10T-E | Human | Esophagus | ESCC | 7.44e-16 | 3.02e-01 | 0.116 |
2161 | F12 | P11T-E | Human | Esophagus | ESCC | 1.28e-03 | 3.17e-01 | 0.1426 |
2161 | F12 | P12T-E | Human | Esophagus | ESCC | 4.33e-24 | 6.02e-01 | 0.1122 |
2161 | F12 | P15T-E | Human | Esophagus | ESCC | 3.66e-26 | 6.47e-01 | 0.1149 |
2161 | F12 | P16T-E | Human | Esophagus | ESCC | 4.79e-16 | 3.87e-01 | 0.1153 |
2161 | F12 | P17T-E | Human | Esophagus | ESCC | 1.57e-05 | 2.99e-01 | 0.1278 |
2161 | F12 | P19T-E | Human | Esophagus | ESCC | 1.10e-02 | 7.09e-01 | 0.1662 |
2161 | F12 | P20T-E | Human | Esophagus | ESCC | 1.16e-17 | 4.24e-01 | 0.1124 |
2161 | F12 | P21T-E | Human | Esophagus | ESCC | 4.64e-28 | 6.15e-01 | 0.1617 |
2161 | F12 | P22T-E | Human | Esophagus | ESCC | 2.01e-19 | 4.29e-01 | 0.1236 |
2161 | F12 | P23T-E | Human | Esophagus | ESCC | 3.95e-12 | 4.44e-01 | 0.108 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:19030348 | Breast | Precancer | regulation of response to wounding | 19/1080 | 167/18723 | 3.60e-03 | 2.98e-02 | 19 |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:200123514 | Breast | IDC | positive regulation of apoptotic signaling pathway | 31/1434 | 126/18723 | 4.13e-09 | 3.35e-07 | 31 |
GO:009719114 | Breast | IDC | extrinsic apoptotic signaling pathway | 42/1434 | 219/18723 | 2.56e-08 | 1.73e-06 | 42 |
GO:200123614 | Breast | IDC | regulation of extrinsic apoptotic signaling pathway | 32/1434 | 151/18723 | 1.07e-07 | 6.26e-06 | 32 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:20012385 | Breast | IDC | positive regulation of extrinsic apoptotic signaling pathway | 12/1434 | 48/18723 | 2.03e-04 | 3.32e-03 | 12 |
GO:190303413 | Breast | IDC | regulation of response to wounding | 24/1434 | 167/18723 | 2.07e-03 | 1.95e-02 | 24 |
GO:200123324 | Breast | DCIS | regulation of apoptotic signaling pathway | 81/1390 | 356/18723 | 3.51e-20 | 3.31e-17 | 81 |
GO:200123523 | Breast | DCIS | positive regulation of apoptotic signaling pathway | 31/1390 | 126/18723 | 1.96e-09 | 1.76e-07 | 31 |
GO:009719123 | Breast | DCIS | extrinsic apoptotic signaling pathway | 40/1390 | 219/18723 | 9.43e-08 | 5.28e-06 | 40 |
GO:200123623 | Breast | DCIS | regulation of extrinsic apoptotic signaling pathway | 31/1390 | 151/18723 | 1.79e-07 | 9.04e-06 | 31 |
GO:004206024 | Breast | DCIS | wound healing | 54/1390 | 422/18723 | 6.09e-05 | 1.22e-03 | 54 |
GO:200123812 | Breast | DCIS | positive regulation of extrinsic apoptotic signaling pathway | 12/1390 | 48/18723 | 1.51e-04 | 2.55e-03 | 12 |
GO:190303422 | Breast | DCIS | regulation of response to wounding | 24/1390 | 167/18723 | 1.37e-03 | 1.42e-02 | 24 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Breast | DCIS |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Breast | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | ADJ |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | AEH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | EEC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Esophagus | ESCC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | ADJ |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | OSCC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Liver | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | AAH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | IAC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | MIAC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Prostate | BPH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Prostate | Healthy |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F12 | insertion | Frame_Shift_Ins | novel | c.812_813insA | p.Asn271LysfsTer40 | p.N271Kfs*40 | P00748 | protein_coding | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
F12 | insertion | Frame_Shift_Ins | novel | c.191_192insA | p.Arg66ProfsTer15 | p.R66Pfs*15 | P00748 | protein_coding | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | ||
F12 | SNV | Missense_Mutation | c.1467N>A | p.Ser489Arg | p.S489R | P00748 | protein_coding | tolerated(0.24) | benign(0.048) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
F12 | SNV | Missense_Mutation | c.1610N>A | p.Val537Glu | p.V537E | P00748 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
F12 | SNV | Missense_Mutation | c.560G>T | p.Gly187Val | p.G187V | P00748 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
F12 | SNV | Missense_Mutation | c.778N>A | p.Leu260Met | p.L260M | P00748 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
F12 | SNV | Missense_Mutation | novel | c.235T>A | p.Phe79Ile | p.F79I | P00748 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
F12 | SNV | Missense_Mutation | c.1527C>A | p.Phe509Leu | p.F509L | P00748 | protein_coding | tolerated(0.45) | benign(0.334) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
F12 | SNV | Missense_Mutation | novel | c.1758N>T | p.Trp586Cys | p.W586C | P00748 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7391-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F12 | SNV | Missense_Mutation | novel | c.1034N>T | p.Arg345Leu | p.R345L | P00748 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-CV-6953-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2161 | F12 | DRUGGABLE GENOME, ENZYME, PROTEASE | ANTITHROMBIN | |||
2161 | F12 | DRUGGABLE GENOME, ENZYME, PROTEASE | BORTEZOMIB | BORTEZOMIB | 20875739 | |
2161 | F12 | DRUGGABLE GENOME, ENZYME, PROTEASE | Enzymes | 23280790 | ||
2161 | F12 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 178103167 | ||
2161 | F12 | DRUGGABLE GENOME, ENZYME, PROTEASE | PENTAMIDINE ISETHIONATE | PENTAMIDINE ISETHIONATE |
Page: 1 |