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Gene: ERN2 |
Gene summary for ERN2 |
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Gene information | Species | Human | Gene symbol | ERN2 | Gene ID | 10595 |
Gene name | endoplasmic reticulum to nucleus signaling 2 | |
Gene Alias | IRE1-BETA | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A5YM46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10595 | ERN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.89e-23 | 7.72e-01 | -0.1954 |
10595 | ERN2 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.45e-04 | 7.46e-01 | -0.2602 |
10595 | ERN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.69e-05 | 5.64e-01 | -0.1464 |
10595 | ERN2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.69e-02 | 4.33e-01 | -0.1001 |
10595 | ERN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.91e-11 | -4.08e-01 | 0.294 |
10595 | ERN2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.47e-25 | -5.98e-01 | 0.3859 |
10595 | ERN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.38e-34 | -7.03e-01 | 0.3005 |
10595 | ERN2 | F007 | Human | Colorectum | FAP | 6.02e-05 | -4.21e-01 | 0.1176 |
10595 | ERN2 | A002-C-010 | Human | Colorectum | FAP | 7.43e-04 | -2.47e-01 | 0.242 |
10595 | ERN2 | A015-C-203 | Human | Colorectum | FAP | 4.41e-28 | -2.88e-01 | -0.1294 |
10595 | ERN2 | A015-C-204 | Human | Colorectum | FAP | 9.84e-04 | -2.31e-01 | -0.0228 |
10595 | ERN2 | A014-C-040 | Human | Colorectum | FAP | 8.76e-03 | -4.31e-01 | -0.1184 |
10595 | ERN2 | A002-C-201 | Human | Colorectum | FAP | 3.07e-12 | -3.27e-01 | 0.0324 |
10595 | ERN2 | A001-C-119 | Human | Colorectum | FAP | 6.39e-04 | -2.51e-01 | -0.1557 |
10595 | ERN2 | A001-C-108 | Human | Colorectum | FAP | 2.83e-17 | -1.52e-01 | -0.0272 |
10595 | ERN2 | A002-C-205 | Human | Colorectum | FAP | 1.65e-19 | -4.07e-01 | -0.1236 |
10595 | ERN2 | A001-C-104 | Human | Colorectum | FAP | 5.85e-03 | -2.00e-02 | 0.0184 |
10595 | ERN2 | A015-C-006 | Human | Colorectum | FAP | 1.51e-10 | -1.63e-01 | -0.0994 |
10595 | ERN2 | A015-C-106 | Human | Colorectum | FAP | 1.52e-09 | 2.83e-03 | -0.0511 |
10595 | ERN2 | A002-C-114 | Human | Colorectum | FAP | 2.23e-12 | -2.54e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0035967 | Colorectum | AD | cellular response to topologically incorrect protein | 42/3918 | 116/18723 | 1.04e-04 | 1.56e-03 | 42 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0006986 | Colorectum | AD | response to unfolded protein | 45/3918 | 137/18723 | 7.43e-04 | 7.48e-03 | 45 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0034620 | Colorectum | AD | cellular response to unfolded protein | 33/3918 | 96/18723 | 1.53e-03 | 1.29e-02 | 33 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:0071902 | Colorectum | AD | positive regulation of protein serine/threonine kinase activity | 58/3918 | 200/18723 | 4.09e-03 | 2.84e-02 | 58 |
GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERN2 | SNV | Missense_Mutation | rs141088910 | c.320C>T | p.Thr107Ile | p.T107I | Q76MJ5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERN2 | SNV | Missense_Mutation | novel | c.2309C>T | p.Pro770Leu | p.P770L | Q76MJ5 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
ERN2 | SNV | Missense_Mutation | c.2528N>A | p.Gly843Glu | p.G843E | Q76MJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
ERN2 | SNV | Missense_Mutation | c.1907G>A | p.Arg636Gln | p.R636Q | Q76MJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ERN2 | SNV | Missense_Mutation | c.520N>A | p.Pro174Thr | p.P174T | Q76MJ5 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
ERN2 | SNV | Missense_Mutation | c.2143N>C | p.Tyr715His | p.Y715H | Q76MJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A029-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ERN2 | SNV | Missense_Mutation | c.148C>T | p.Leu50Phe | p.L50F | Q76MJ5 | protein_coding | tolerated(0.09) | probably_damaging(0.948) | TCGA-AA-A02H-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ERN2 | SNV | Missense_Mutation | c.2221C>G | p.Leu741Val | p.L741V | Q76MJ5 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ERN2 | SNV | Missense_Mutation | rs140769667 | c.722G>A | p.Arg241His | p.R241H | Q76MJ5 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERN2 | SNV | Missense_Mutation | novel | c.1229T>G | p.Leu410Arg | p.L410R | Q76MJ5 | protein_coding | tolerated(0.52) | benign(0.045) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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