![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ERGIC1 |
Gene summary for ERGIC1 |
![]() |
Gene information | Species | Human | Gene symbol | ERGIC1 | Gene ID | 57222 |
Gene name | endoplasmic reticulum-golgi intermediate compartment 1 | |
Gene Alias | AMC2 | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q969X5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57222 | ERGIC1 | GSM4909290 | Human | Breast | IDC | 4.57e-02 | 2.02e-01 | 0.2096 |
57222 | ERGIC1 | GSM4909291 | Human | Breast | IDC | 1.12e-07 | 3.74e-01 | 0.1753 |
57222 | ERGIC1 | GSM4909292 | Human | Breast | IDC | 6.36e-05 | 6.16e-01 | 0.1236 |
57222 | ERGIC1 | GSM4909293 | Human | Breast | IDC | 4.06e-37 | 6.27e-01 | 0.1581 |
57222 | ERGIC1 | GSM4909297 | Human | Breast | IDC | 7.59e-03 | 4.13e-02 | 0.1517 |
57222 | ERGIC1 | GSM4909298 | Human | Breast | IDC | 1.06e-32 | 6.43e-01 | 0.1551 |
57222 | ERGIC1 | GSM4909304 | Human | Breast | IDC | 4.29e-07 | 2.72e-01 | 0.1636 |
57222 | ERGIC1 | GSM4909308 | Human | Breast | IDC | 4.45e-11 | 3.52e-01 | 0.158 |
57222 | ERGIC1 | GSM4909311 | Human | Breast | IDC | 1.13e-10 | 2.18e-02 | 0.1534 |
57222 | ERGIC1 | GSM4909312 | Human | Breast | IDC | 5.41e-05 | 2.13e-01 | 0.1552 |
57222 | ERGIC1 | GSM4909317 | Human | Breast | IDC | 4.67e-08 | 3.30e-01 | 0.1355 |
57222 | ERGIC1 | GSM4909319 | Human | Breast | IDC | 3.26e-15 | -2.93e-02 | 0.1563 |
57222 | ERGIC1 | GSM4909321 | Human | Breast | IDC | 4.99e-05 | 1.84e-01 | 0.1559 |
57222 | ERGIC1 | M1 | Human | Breast | IDC | 7.65e-11 | 4.43e-01 | 0.1577 |
57222 | ERGIC1 | NCCBC14 | Human | Breast | DCIS | 4.88e-03 | 1.18e-01 | 0.2021 |
57222 | ERGIC1 | P1 | Human | Breast | IDC | 1.09e-03 | 1.47e-01 | 0.1527 |
57222 | ERGIC1 | DCIS2 | Human | Breast | DCIS | 7.46e-39 | 1.22e-01 | 0.0085 |
57222 | ERGIC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.65e-14 | 7.93e-01 | -0.1808 |
57222 | ERGIC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.57e-12 | 6.99e-01 | -0.0811 |
57222 | ERGIC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.51e-21 | 1.07e+00 | -0.1088 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068906 | Breast | IDC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 10/1434 | 52/18723 | 5.49e-03 | 4.03e-02 | 10 |
GO:000689012 | Breast | DCIS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 10/1390 | 52/18723 | 4.41e-03 | 3.41e-02 | 10 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006890 | Colorectum | AD | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/3918 | 52/18723 | 7.67e-07 | 2.70e-05 | 27 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068901 | Colorectum | SER | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 20/2897 | 52/18723 | 4.80e-05 | 1.18e-03 | 20 |
GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00068902 | Colorectum | MSS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 26/3467 | 52/18723 | 2.66e-07 | 1.10e-05 | 26 |
GO:00068882 | Colorectum | MSS | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3467 | 130/18723 | 2.17e-05 | 4.60e-04 | 44 |
GO:00068903 | Colorectum | MSI-H | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 13/1319 | 52/18723 | 4.72e-05 | 1.69e-03 | 13 |
GO:00068883 | Colorectum | MSI-H | endoplasmic reticulum to Golgi vesicle-mediated transport | 22/1319 | 130/18723 | 1.05e-04 | 3.24e-03 | 22 |
GO:00481933 | Colorectum | MSI-H | Golgi vesicle transport | 39/1319 | 296/18723 | 1.17e-04 | 3.51e-03 | 39 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00068904 | Colorectum | FAP | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 18/2622 | 52/18723 | 1.48e-04 | 2.29e-03 | 18 |
GO:00068884 | Colorectum | FAP | endoplasmic reticulum to Golgi vesicle-mediated transport | 30/2622 | 130/18723 | 3.51e-03 | 2.53e-02 | 30 |
GO:00481935 | Colorectum | CRC | Golgi vesicle transport | 59/2078 | 296/18723 | 5.47e-06 | 2.17e-04 | 59 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERGIC1 | SNV | Missense_Mutation | rs766575211 | c.304N>A | p.Asp102Asn | p.D102N | Q969X5 | protein_coding | tolerated(0.12) | benign(0.183) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERGIC1 | SNV | Missense_Mutation | novel | c.671G>A | p.Arg224His | p.R224H | Q969X5 | protein_coding | tolerated(0.06) | probably_damaging(0.947) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERGIC1 | SNV | Missense_Mutation | novel | c.238N>A | p.Leu80Met | p.L80M | Q969X5 | protein_coding | tolerated(0.32) | benign(0.285) | TCGA-EY-A2OM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
ERGIC1 | SNV | Missense_Mutation | rs140909162 | c.562N>C | p.Ile188Leu | p.I188L | Q969X5 | protein_coding | tolerated(0.23) | benign(0.081) | TCGA-ZP-A9D0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERGIC1 | SNV | Missense_Mutation | c.73N>T | p.Gly25Trp | p.G25W | Q969X5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-80-5608-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
ERGIC1 | SNV | Missense_Mutation | c.148A>G | p.Thr50Ala | p.T50A | Q969X5 | protein_coding | tolerated(0.77) | benign(0.038) | TCGA-86-8054-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR | |
ERGIC1 | SNV | Missense_Mutation | novel | c.243N>G | p.His81Gln | p.H81Q | Q969X5 | protein_coding | tolerated(0.34) | benign(0.054) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERGIC1 | SNV | Missense_Mutation | rs566933192 | c.737N>A | p.Arg246Gln | p.R246Q | Q969X5 | protein_coding | deleterious(0.02) | probably_damaging(0.943) | TCGA-92-7341-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ERGIC1 | SNV | Missense_Mutation | rs766575211 | c.304N>A | p.Asp102Asn | p.D102N | Q969X5 | protein_coding | tolerated(0.12) | benign(0.183) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
ERGIC1 | SNV | Missense_Mutation | c.29N>G | p.Ile10Ser | p.I10S | Q969X5 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-HU-A4GD-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |