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Gene: EPOR |
Gene summary for EPOR |
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Gene information | Species | Human | Gene symbol | EPOR | Gene ID | 2057 |
Gene name | erythropoietin receptor | |
Gene Alias | EPO-R | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P19235 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2057 | EPOR | male-WTA | Human | Thyroid | PTC | 2.26e-37 | 4.21e-01 | 0.1037 |
2057 | EPOR | PTC01 | Human | Thyroid | PTC | 1.91e-06 | 1.67e-01 | 0.1899 |
2057 | EPOR | PTC03 | Human | Thyroid | PTC | 1.63e-03 | 3.63e-01 | 0.1784 |
2057 | EPOR | PTC04 | Human | Thyroid | PTC | 1.02e-44 | 6.96e-01 | 0.1927 |
2057 | EPOR | PTC05 | Human | Thyroid | PTC | 7.86e-11 | 5.75e-01 | 0.2065 |
2057 | EPOR | PTC06 | Human | Thyroid | PTC | 1.60e-27 | 6.93e-01 | 0.2057 |
2057 | EPOR | PTC07 | Human | Thyroid | PTC | 7.95e-25 | 4.13e-01 | 0.2044 |
2057 | EPOR | ATC12 | Human | Thyroid | ATC | 1.17e-02 | 8.87e-04 | 0.34 |
2057 | EPOR | ATC13 | Human | Thyroid | ATC | 4.71e-12 | 1.60e-01 | 0.34 |
2057 | EPOR | ATC5 | Human | Thyroid | ATC | 1.60e-11 | 1.87e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061458112 | Thyroid | PTC | reproductive system development | 173/5968 | 427/18723 | 8.70e-05 | 7.23e-04 | 173 |
GO:0048608111 | Thyroid | PTC | reproductive structure development | 170/5968 | 424/18723 | 1.86e-04 | 1.41e-03 | 170 |
GO:0001890112 | Thyroid | PTC | placenta development | 66/5968 | 144/18723 | 3.06e-04 | 2.14e-03 | 66 |
GO:000189315 | Thyroid | PTC | maternal placenta development | 18/5968 | 35/18723 | 1.26e-02 | 4.90e-02 | 18 |
GO:006145827 | Thyroid | ATC | reproductive system development | 193/6293 | 427/18723 | 3.32e-07 | 4.92e-06 | 193 |
GO:004860825 | Thyroid | ATC | reproductive structure development | 190/6293 | 424/18723 | 8.40e-07 | 1.11e-05 | 190 |
GO:000189026 | Thyroid | ATC | placenta development | 70/6293 | 144/18723 | 1.33e-04 | 9.33e-04 | 70 |
GO:000189321 | Thyroid | ATC | maternal placenta development | 21/6293 | 35/18723 | 1.22e-03 | 6.41e-03 | 21 |
GO:000756517 | Thyroid | ATC | female pregnancy | 82/6293 | 193/18723 | 6.04e-03 | 2.42e-02 | 82 |
GO:00601358 | Thyroid | ATC | maternal process involved in female pregnancy | 30/6293 | 62/18723 | 1.12e-02 | 4.00e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPOR | SNV | Missense_Mutation | rs139756642 | c.860N>T | p.Pro287Leu | p.P287L | P19235 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-M7-A725-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
EPOR | SNV | Missense_Mutation | c.193G>A | p.Glu65Lys | p.E65K | P19235 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
EPOR | SNV | Missense_Mutation | novel | c.403N>A | p.Arg135Ser | p.R135S | P19235 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EL-A3GX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA | |||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | Epoetin zeta | |||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | agonist | CHEMBL1201566 | DARBEPOETIN ALFA | |
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | agonist | 348353636 | CIBINETIDE | |
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | ErepoXen | |||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | HEMATIDE | PEGINESATIDE | ||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | agonist | CHEMBL2107866 | PEGINESATIDE | |
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | DARBEPOETIN ALFA | |||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | DARBEPOETIN ALFA | |||
2057 | EPOR | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSCRIPTION FACTOR, KINASE, DRUGGABLE GENOME | Darbepoetin alfa |
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