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Gene: ENOX2 |
Gene summary for ENOX2 |
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Gene information | Species | Human | Gene symbol | ENOX2 | Gene ID | 10495 |
Gene name | ecto-NOX disulfide-thiol exchanger 2 | |
Gene Alias | APK1 | |
Cytomap | Xq26.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | Q16206 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10495 | ENOX2 | LZE4T | Human | Esophagus | ESCC | 3.20e-03 | 1.51e-01 | 0.0811 |
10495 | ENOX2 | LZE20T | Human | Esophagus | ESCC | 5.95e-03 | 1.53e-01 | 0.0662 |
10495 | ENOX2 | LZE24T | Human | Esophagus | ESCC | 1.59e-08 | 2.87e-01 | 0.0596 |
10495 | ENOX2 | P1T-E | Human | Esophagus | ESCC | 2.41e-02 | 1.92e-01 | 0.0875 |
10495 | ENOX2 | P2T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.34e-01 | 0.1177 |
10495 | ENOX2 | P4T-E | Human | Esophagus | ESCC | 3.41e-10 | 2.11e-01 | 0.1323 |
10495 | ENOX2 | P5T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.09e-01 | 0.1327 |
10495 | ENOX2 | P8T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.27e-01 | 0.0889 |
10495 | ENOX2 | P9T-E | Human | Esophagus | ESCC | 3.71e-10 | 2.67e-01 | 0.1131 |
10495 | ENOX2 | P10T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.20e-01 | 0.116 |
10495 | ENOX2 | P11T-E | Human | Esophagus | ESCC | 1.29e-02 | 2.11e-01 | 0.1426 |
10495 | ENOX2 | P12T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.62e-01 | 0.1122 |
10495 | ENOX2 | P15T-E | Human | Esophagus | ESCC | 1.02e-06 | 1.69e-01 | 0.1149 |
10495 | ENOX2 | P16T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.40e-01 | 0.1153 |
10495 | ENOX2 | P17T-E | Human | Esophagus | ESCC | 6.62e-03 | 2.43e-01 | 0.1278 |
10495 | ENOX2 | P20T-E | Human | Esophagus | ESCC | 6.63e-08 | 2.51e-01 | 0.1124 |
10495 | ENOX2 | P21T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.67e-01 | 0.1617 |
10495 | ENOX2 | P22T-E | Human | Esophagus | ESCC | 7.52e-23 | 3.78e-01 | 0.1236 |
10495 | ENOX2 | P23T-E | Human | Esophagus | ESCC | 3.24e-23 | 5.49e-01 | 0.108 |
10495 | ENOX2 | P24T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.15e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0022900110 | Esophagus | ESCC | electron transport chain | 133/8552 | 175/18723 | 2.18e-16 | 1.67e-14 | 133 |
GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
GO:00060917 | Liver | NAFLD | generation of precursor metabolites and energy | 84/1882 | 490/18723 | 7.03e-07 | 3.95e-05 | 84 |
GO:00485115 | Liver | NAFLD | rhythmic process | 56/1882 | 298/18723 | 3.03e-06 | 1.23e-04 | 56 |
GO:00229007 | Liver | NAFLD | electron transport chain | 29/1882 | 175/18723 | 4.87e-03 | 3.84e-02 | 29 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:002290022 | Liver | HCC | electron transport chain | 134/7958 | 175/18723 | 3.32e-20 | 4.68e-18 | 134 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:002290018 | Oral cavity | OSCC | electron transport chain | 126/7305 | 175/18723 | 6.65e-19 | 8.42e-17 | 126 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
GO:002290019 | Oral cavity | LP | electron transport chain | 108/4623 | 175/18723 | 2.21e-25 | 9.90e-23 | 108 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENOX2 | SNV | Missense_Mutation | c.901N>T | p.Arg301Cys | p.R301C | Q16206 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENOX2 | SNV | Missense_Mutation | rs770968891 | c.554G>A | p.Arg185His | p.R185H | Q16206 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD |
ENOX2 | SNV | Missense_Mutation | c.926C>A | p.Ala309Asp | p.A309D | Q16206 | protein_coding | tolerated(0.45) | benign(0.081) | TCGA-D5-6923-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENOX2 | SNV | Missense_Mutation | c.1276G>A | p.Asp426Asn | p.D426N | Q16206 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENOX2 | SNV | Missense_Mutation | novel | c.10N>T | p.Asp4Tyr | p.D4Y | Q16206 | protein_coding | deleterious_low_confidence(0) | benign(0.026) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENOX2 | insertion | Frame_Shift_Ins | novel | c.1493_1494insA | p.Asn498LysfsTer3 | p.N498Kfs*3 | Q16206 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ENOX2 | SNV | Missense_Mutation | novel | c.969G>T | p.Gln323His | p.Q323H | Q16206 | protein_coding | tolerated(0.21) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENOX2 | SNV | Missense_Mutation | novel | c.149C>T | p.Ala50Val | p.A50V | Q16206 | protein_coding | tolerated(0.32) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENOX2 | SNV | Missense_Mutation | rs201000646 | c.904N>T | p.Arg302Cys | p.R302C | Q16206 | protein_coding | deleterious(0.03) | benign(0.054) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ENOX2 | SNV | Missense_Mutation | c.163G>A | p.Ala55Thr | p.A55T | Q16206 | protein_coding | tolerated(0.7) | benign(0) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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