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Gene: EMC1 |
Gene summary for EMC1 |
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Gene information | Species | Human | Gene symbol | EMC1 | Gene ID | 23065 |
Gene name | ER membrane protein complex subunit 1 | |
Gene Alias | CAVIPMR | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8N766 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23065 | EMC1 | LZE7T | Human | Esophagus | ESCC | 1.81e-04 | 1.97e-01 | 0.0667 |
23065 | EMC1 | LZE8T | Human | Esophagus | ESCC | 1.65e-03 | 6.35e-02 | 0.067 |
23065 | EMC1 | LZE24T | Human | Esophagus | ESCC | 2.18e-10 | 1.29e-01 | 0.0596 |
23065 | EMC1 | P2T-E | Human | Esophagus | ESCC | 1.09e-33 | 4.53e-01 | 0.1177 |
23065 | EMC1 | P4T-E | Human | Esophagus | ESCC | 1.43e-05 | 2.18e-01 | 0.1323 |
23065 | EMC1 | P5T-E | Human | Esophagus | ESCC | 3.47e-11 | 3.30e-02 | 0.1327 |
23065 | EMC1 | P8T-E | Human | Esophagus | ESCC | 4.48e-17 | 1.90e-01 | 0.0889 |
23065 | EMC1 | P9T-E | Human | Esophagus | ESCC | 3.31e-09 | 3.19e-02 | 0.1131 |
23065 | EMC1 | P10T-E | Human | Esophagus | ESCC | 9.75e-20 | 2.82e-01 | 0.116 |
23065 | EMC1 | P11T-E | Human | Esophagus | ESCC | 1.63e-20 | 5.04e-01 | 0.1426 |
23065 | EMC1 | P12T-E | Human | Esophagus | ESCC | 2.95e-21 | 2.41e-01 | 0.1122 |
23065 | EMC1 | P15T-E | Human | Esophagus | ESCC | 5.28e-26 | 6.56e-01 | 0.1149 |
23065 | EMC1 | P16T-E | Human | Esophagus | ESCC | 1.02e-26 | 3.79e-01 | 0.1153 |
23065 | EMC1 | P17T-E | Human | Esophagus | ESCC | 1.30e-08 | 4.18e-01 | 0.1278 |
23065 | EMC1 | P19T-E | Human | Esophagus | ESCC | 8.91e-04 | 3.87e-01 | 0.1662 |
23065 | EMC1 | P20T-E | Human | Esophagus | ESCC | 1.24e-10 | 3.34e-01 | 0.1124 |
23065 | EMC1 | P21T-E | Human | Esophagus | ESCC | 4.54e-32 | 6.72e-01 | 0.1617 |
23065 | EMC1 | P22T-E | Human | Esophagus | ESCC | 3.31e-21 | 1.18e-01 | 0.1236 |
23065 | EMC1 | P23T-E | Human | Esophagus | ESCC | 1.46e-12 | 1.93e-01 | 0.108 |
23065 | EMC1 | P24T-E | Human | Esophagus | ESCC | 1.35e-16 | 2.05e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:009013014 | Endometrium | AEH | tissue migration | 73/2100 | 365/18723 | 5.79e-07 | 2.20e-05 | 73 |
GO:009013214 | Endometrium | AEH | epithelium migration | 72/2100 | 360/18723 | 6.90e-07 | 2.55e-05 | 72 |
GO:001063114 | Endometrium | AEH | epithelial cell migration | 71/2100 | 357/18723 | 1.02e-06 | 3.52e-05 | 71 |
GO:001063214 | Endometrium | AEH | regulation of epithelial cell migration | 60/2100 | 292/18723 | 2.31e-06 | 6.77e-05 | 60 |
GO:00506788 | Endometrium | AEH | regulation of epithelial cell proliferation | 73/2100 | 381/18723 | 3.04e-06 | 8.44e-05 | 73 |
GO:001063410 | Endometrium | AEH | positive regulation of epithelial cell migration | 41/2100 | 176/18723 | 3.79e-06 | 1.01e-04 | 41 |
GO:00514039 | Endometrium | AEH | stress-activated MAPK cascade | 50/2100 | 239/18723 | 9.33e-06 | 2.18e-04 | 50 |
GO:00310989 | Endometrium | AEH | stress-activated protein kinase signaling cascade | 51/2100 | 247/18723 | 1.12e-05 | 2.52e-04 | 51 |
GO:00328728 | Endometrium | AEH | regulation of stress-activated MAPK cascade | 42/2100 | 192/18723 | 1.53e-05 | 3.23e-04 | 42 |
GO:00380665 | Endometrium | AEH | p38MAPK cascade | 18/2100 | 55/18723 | 1.77e-05 | 3.65e-04 | 18 |
GO:00435428 | Endometrium | AEH | endothelial cell migration | 55/2100 | 279/18723 | 2.11e-05 | 4.15e-04 | 55 |
GO:00105955 | Endometrium | AEH | positive regulation of endothelial cell migration | 32/2100 | 133/18723 | 2.12e-05 | 4.15e-04 | 32 |
GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
GO:00703028 | Endometrium | AEH | regulation of stress-activated protein kinase signaling cascade | 42/2100 | 195/18723 | 2.27e-05 | 4.35e-04 | 42 |
GO:00105945 | Endometrium | AEH | regulation of endothelial cell migration | 47/2100 | 232/18723 | 4.02e-05 | 6.91e-04 | 47 |
GO:00506795 | Endometrium | AEH | positive regulation of epithelial cell proliferation | 43/2100 | 207/18723 | 4.55e-05 | 7.61e-04 | 43 |
GO:009015010 | Endometrium | AEH | establishment of protein localization to membrane | 51/2100 | 260/18723 | 4.74e-05 | 7.85e-04 | 51 |
GO:19007443 | Endometrium | AEH | regulation of p38MAPK cascade | 15/2100 | 47/18723 | 1.21e-04 | 1.67e-03 | 15 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC1 | SNV | Missense_Mutation | rs761543184 | c.311N>A | p.Gly104Asp | p.G104D | Q8N766 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC1 | SNV | Missense_Mutation | c.2410N>A | p.Glu804Lys | p.E804K | Q8N766 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EMC1 | SNV | Missense_Mutation | c.946N>C | p.Phe316Leu | p.F316L | Q8N766 | protein_coding | tolerated(0.37) | possibly_damaging(0.6) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EMC1 | SNV | Missense_Mutation | novel | c.338N>T | p.Asn113Ile | p.N113I | Q8N766 | protein_coding | tolerated(0.13) | possibly_damaging(0.824) | TCGA-AA-A029-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EMC1 | SNV | Missense_Mutation | c.713N>A | p.Pro238His | p.P238H | Q8N766 | protein_coding | tolerated(0.49) | possibly_damaging(0.75) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EMC1 | SNV | Missense_Mutation | rs778938462 | c.2644N>T | p.Arg882Cys | p.R882C | Q8N766 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC1 | SNV | Missense_Mutation | c.1434N>G | p.Asp478Glu | p.D478E | Q8N766 | protein_coding | tolerated(0.1) | benign(0.146) | TCGA-NH-A6GC-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD | |
EMC1 | SNV | Missense_Mutation | rs777684249 | c.2650N>A | p.Glu884Lys | p.E884K | Q8N766 | protein_coding | deleterious(0.03) | possibly_damaging(0.833) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EMC1 | SNV | Missense_Mutation | novel | c.247N>A | p.Ala83Thr | p.A83T | Q8N766 | protein_coding | tolerated(0.06) | benign(0.067) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EMC1 | deletion | Frame_Shift_Del | novel | c.2922delN | p.Phe974LeufsTer4 | p.F974Lfs*4 | Q8N766 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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