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Gene: ELF4 |
Gene summary for ELF4 |
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Gene information | Species | Human | Gene symbol | ELF4 | Gene ID | 2000 |
Gene name | E74 like ETS transcription factor 4 | |
Gene Alias | ELFR | |
Cytomap | Xq26.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q99607 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2000 | ELF4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.44e-02 | 2.75e-01 | -0.1808 |
2000 | ELF4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.41e-03 | 2.69e-01 | -0.0811 |
2000 | ELF4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.57e-07 | 3.66e-01 | -0.1954 |
2000 | ELF4 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.47e-04 | 7.66e-01 | -0.2602 |
2000 | ELF4 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.79e-10 | 3.70e-01 | -0.1464 |
2000 | ELF4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.14e-03 | 4.20e-01 | -0.2061 |
2000 | ELF4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.34e-03 | 2.80e-01 | 0.3005 |
2000 | ELF4 | LZE24T | Human | Esophagus | ESCC | 1.02e-04 | 1.46e-01 | 0.0596 |
2000 | ELF4 | P1T-E | Human | Esophagus | ESCC | 1.37e-02 | 1.19e-01 | 0.0875 |
2000 | ELF4 | P5T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.10e-02 | 0.1327 |
2000 | ELF4 | P8T-E | Human | Esophagus | ESCC | 4.50e-09 | 1.05e-01 | 0.0889 |
2000 | ELF4 | P9T-E | Human | Esophagus | ESCC | 5.47e-03 | 1.16e-01 | 0.1131 |
2000 | ELF4 | P10T-E | Human | Esophagus | ESCC | 4.34e-08 | 1.90e-01 | 0.116 |
2000 | ELF4 | P12T-E | Human | Esophagus | ESCC | 7.71e-07 | 6.64e-02 | 0.1122 |
2000 | ELF4 | P15T-E | Human | Esophagus | ESCC | 2.79e-06 | 7.46e-02 | 0.1149 |
2000 | ELF4 | P17T-E | Human | Esophagus | ESCC | 1.24e-03 | 2.19e-01 | 0.1278 |
2000 | ELF4 | P20T-E | Human | Esophagus | ESCC | 4.34e-06 | 1.84e-01 | 0.1124 |
2000 | ELF4 | P21T-E | Human | Esophagus | ESCC | 1.20e-08 | 2.56e-01 | 0.1617 |
2000 | ELF4 | P22T-E | Human | Esophagus | ESCC | 2.45e-11 | 2.18e-01 | 0.1236 |
2000 | ELF4 | P23T-E | Human | Esophagus | ESCC | 1.93e-08 | 3.16e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:004211016 | Oral cavity | OSCC | T cell activation | 245/7305 | 487/18723 | 2.00e-07 | 3.22e-06 | 245 |
GO:004209816 | Oral cavity | OSCC | T cell proliferation | 100/7305 | 199/18723 | 7.93e-04 | 4.27e-03 | 100 |
GO:00466333 | Oral cavity | OSCC | alpha-beta T cell proliferation | 24/7305 | 38/18723 | 2.21e-03 | 1.00e-02 | 24 |
GO:00706618 | Oral cavity | OSCC | leukocyte proliferation | 145/7305 | 318/18723 | 9.31e-03 | 3.33e-02 | 145 |
GO:00466517 | Oral cavity | OSCC | lymphocyte proliferation | 131/7305 | 288/18723 | 1.41e-02 | 4.67e-02 | 131 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:1903311112 | Thyroid | PTC | regulation of mRNA metabolic process | 181/5968 | 288/18723 | 1.60e-27 | 5.94e-25 | 181 |
GO:0050684112 | Thyroid | PTC | regulation of mRNA processing | 98/5968 | 137/18723 | 1.53e-21 | 3.10e-19 | 98 |
GO:0043484113 | Thyroid | PTC | regulation of RNA splicing | 102/5968 | 148/18723 | 2.03e-20 | 3.21e-18 | 102 |
GO:0071826113 | Thyroid | PTC | ribonucleoprotein complex subunit organization | 134/5968 | 227/18723 | 2.34e-17 | 2.24e-15 | 134 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0022618113 | Thyroid | PTC | ribonucleoprotein complex assembly | 130/5968 | 220/18723 | 6.25e-17 | 5.47e-15 | 130 |
GO:0048024113 | Thyroid | PTC | regulation of mRNA splicing, via spliceosome | 71/5968 | 101/18723 | 2.39e-15 | 1.71e-13 | 71 |
GO:1903313110 | Thyroid | PTC | positive regulation of mRNA metabolic process | 76/5968 | 118/18723 | 3.60e-13 | 1.80e-11 | 76 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELF4 | SNV | Missense_Mutation | c.299N>T | p.Asn100Ile | p.N100I | Q99607 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-F4-6808-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ELF4 | SNV | Missense_Mutation | c.1741N>G | p.Thr581Ala | p.T581A | Q99607 | protein_coding | tolerated(0.37) | benign(0) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ELF4 | SNV | Missense_Mutation | novel | c.692G>T | p.Trp231Leu | p.W231L | Q99607 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ELF4 | SNV | Missense_Mutation | novel | c.80N>G | p.Glu27Gly | p.E27G | Q99607 | protein_coding | tolerated(0.11) | benign(0.174) | TCGA-AG-A02G-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PD |
ELF4 | SNV | Missense_Mutation | c.694N>T | p.Thr232Ser | p.T232S | Q99607 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ELF4 | SNV | Missense_Mutation | novel | c.1655C>T | p.Thr552Met | p.T552M | Q99607 | protein_coding | deleterious(0) | possibly_damaging(0.591) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ELF4 | SNV | Missense_Mutation | novel | c.581G>A | p.Ser194Asn | p.S194N | Q99607 | protein_coding | tolerated(0.46) | benign(0.118) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELF4 | SNV | Missense_Mutation | novel | c.421C>T | p.Pro141Ser | p.P141S | Q99607 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELF4 | SNV | Missense_Mutation | novel | c.169N>A | p.Val57Ile | p.V57I | Q99607 | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ELF4 | SNV | Missense_Mutation | c.1426N>T | p.Ala476Ser | p.A476S | Q99607 | protein_coding | tolerated(0.17) | benign(0.038) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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