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Gene: EFS |
Gene summary for EFS |
Gene summary. |
Gene information | Species | Human | Gene symbol | EFS | Gene ID | 10278 |
Gene name | embryonal Fyn-associated substrate | |
Gene Alias | CAS3 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | O43281 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10278 | EFS | LZE7T | Human | Esophagus | ESCC | 2.20e-04 | 1.80e-01 | 0.0667 |
10278 | EFS | LZE24T | Human | Esophagus | ESCC | 4.01e-08 | 1.47e-01 | 0.0596 |
10278 | EFS | P1T-E | Human | Esophagus | ESCC | 1.01e-05 | 2.08e-01 | 0.0875 |
10278 | EFS | P2T-E | Human | Esophagus | ESCC | 3.59e-11 | 1.91e-01 | 0.1177 |
10278 | EFS | P4T-E | Human | Esophagus | ESCC | 1.09e-08 | 1.90e-01 | 0.1323 |
10278 | EFS | P5T-E | Human | Esophagus | ESCC | 3.07e-05 | 2.88e-02 | 0.1327 |
10278 | EFS | P8T-E | Human | Esophagus | ESCC | 6.90e-19 | 2.54e-01 | 0.0889 |
10278 | EFS | P9T-E | Human | Esophagus | ESCC | 5.75e-10 | 1.76e-01 | 0.1131 |
10278 | EFS | P10T-E | Human | Esophagus | ESCC | 1.23e-14 | 2.31e-01 | 0.116 |
10278 | EFS | P11T-E | Human | Esophagus | ESCC | 2.11e-06 | 3.89e-01 | 0.1426 |
10278 | EFS | P12T-E | Human | Esophagus | ESCC | 1.16e-18 | 3.79e-01 | 0.1122 |
10278 | EFS | P15T-E | Human | Esophagus | ESCC | 6.39e-15 | 3.30e-01 | 0.1149 |
10278 | EFS | P16T-E | Human | Esophagus | ESCC | 1.03e-14 | 2.19e-01 | 0.1153 |
10278 | EFS | P17T-E | Human | Esophagus | ESCC | 8.60e-06 | 2.78e-01 | 0.1278 |
10278 | EFS | P20T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.26e-01 | 0.1124 |
10278 | EFS | P21T-E | Human | Esophagus | ESCC | 1.91e-05 | 8.75e-02 | 0.1617 |
10278 | EFS | P22T-E | Human | Esophagus | ESCC | 8.78e-12 | 1.30e-01 | 0.1236 |
10278 | EFS | P23T-E | Human | Esophagus | ESCC | 3.55e-11 | 1.63e-01 | 0.108 |
10278 | EFS | P24T-E | Human | Esophagus | ESCC | 1.25e-07 | 1.01e-01 | 0.1287 |
10278 | EFS | P26T-E | Human | Esophagus | ESCC | 1.29e-04 | 1.00e-01 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:003153218 | Esophagus | ESCC | actin cytoskeleton reorganization | 72/8552 | 107/18723 | 5.03e-06 | 5.31e-05 | 72 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00064177 | Liver | NAFLD | regulation of translation | 85/1882 | 468/18723 | 4.58e-08 | 4.54e-06 | 85 |
GO:00064145 | Liver | NAFLD | translational elongation | 16/1882 | 55/18723 | 6.71e-05 | 1.44e-03 | 16 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
GO:0006417110 | Oral cavity | LP | regulation of translation | 175/4623 | 468/18723 | 4.49e-10 | 2.22e-08 | 175 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFS | SNV | Missense_Mutation | novel | c.737N>T | p.Gly246Val | p.G246V | O43281 | protein_coding | deleterious(0.02) | benign(0.399) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
EFS | SNV | Missense_Mutation | novel | c.1021C>A | p.Pro341Thr | p.P341T | O43281 | protein_coding | deleterious(0) | benign(0.255) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
EFS | SNV | Missense_Mutation | c.395N>T | p.Arg132Ile | p.R132I | O43281 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EFS | SNV | Missense_Mutation | novel | c.1492G>T | p.Ala498Ser | p.A498S | O43281 | protein_coding | tolerated(0.07) | benign(0.078) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | novel | c.1634N>A | p.Leu545Gln | p.L545Q | O43281 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4T7-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | c.860N>T | p.Ser287Ile | p.S287I | O43281 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EFS | SNV | Missense_Mutation | novel | c.1009N>G | p.Leu337Val | p.L337V | O43281 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | c.1424N>G | p.Lys475Arg | p.K475R | O43281 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EFS | insertion | Frame_Shift_Ins | novel | c.350_351insATTT | p.Gly118PhefsTer9 | p.G118Ffs*9 | O43281 | protein_coding | TCGA-85-8276-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | ||
EFS | insertion | In_Frame_Ins | novel | c.349_350insGGACTGTCATTACCC | p.Ala117delinsGlyThrValIleThrPro | p.A117delinsGTVITP | O43281 | protein_coding | TCGA-85-8276-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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