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Gene: EEF2 |
Gene summary for EEF2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | EEF2 | Gene ID | 1938 |
Gene name | eukaryotic translation elongation factor 2 | |
Gene Alias | EEF-2 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P13639 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1938 | EEF2 | GSM4909280 | Human | Breast | Precancer | 4.39e-04 | -5.49e-01 | 0.0305 |
1938 | EEF2 | GSM4909281 | Human | Breast | IDC | 1.79e-33 | -4.63e-01 | 0.21 |
1938 | EEF2 | GSM4909282 | Human | Breast | IDC | 3.42e-54 | -7.43e-01 | -0.0288 |
1938 | EEF2 | GSM4909285 | Human | Breast | IDC | 1.90e-10 | -1.72e-01 | 0.21 |
1938 | EEF2 | GSM4909287 | Human | Breast | IDC | 7.26e-21 | -4.91e-01 | 0.2057 |
1938 | EEF2 | GSM4909290 | Human | Breast | IDC | 1.01e-43 | -7.56e-01 | 0.2096 |
1938 | EEF2 | GSM4909293 | Human | Breast | IDC | 1.07e-38 | -4.81e-01 | 0.1581 |
1938 | EEF2 | GSM4909294 | Human | Breast | IDC | 4.87e-14 | -5.37e-01 | 0.2022 |
1938 | EEF2 | GSM4909295 | Human | Breast | IDC | 2.69e-02 | -2.76e-01 | 0.0898 |
1938 | EEF2 | GSM4909296 | Human | Breast | IDC | 1.13e-07 | -2.86e-01 | 0.1524 |
1938 | EEF2 | GSM4909297 | Human | Breast | IDC | 6.97e-22 | -2.20e-01 | 0.1517 |
1938 | EEF2 | GSM4909298 | Human | Breast | IDC | 1.19e-11 | -1.39e-01 | 0.1551 |
1938 | EEF2 | GSM4909300 | Human | Breast | IDC | 3.83e-08 | -3.62e-01 | 0.0334 |
1938 | EEF2 | GSM4909301 | Human | Breast | IDC | 9.60e-22 | -5.20e-01 | 0.1577 |
1938 | EEF2 | GSM4909302 | Human | Breast | IDC | 3.28e-03 | -2.18e-01 | 0.1545 |
1938 | EEF2 | GSM4909306 | Human | Breast | IDC | 3.45e-28 | -4.28e-01 | 0.1564 |
1938 | EEF2 | GSM4909307 | Human | Breast | IDC | 2.40e-17 | -4.28e-01 | 0.1569 |
1938 | EEF2 | GSM4909308 | Human | Breast | IDC | 3.31e-22 | -2.39e-01 | 0.158 |
1938 | EEF2 | GSM4909309 | Human | Breast | IDC | 4.47e-44 | -8.30e-01 | 0.0483 |
1938 | EEF2 | GSM4909311 | Human | Breast | IDC | 1.25e-36 | -4.04e-01 | 0.1534 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00425429 | Breast | Precancer | response to hydrogen peroxide | 26/1080 | 146/18723 | 2.52e-07 | 1.26e-05 | 26 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:0002931 | Breast | Precancer | response to ischemia | 12/1080 | 58/18723 | 9.65e-05 | 1.80e-03 | 12 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00420633 | Breast | Precancer | gliogenesis | 33/1080 | 301/18723 | 3.06e-04 | 4.40e-03 | 33 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:00323555 | Breast | Precancer | response to estradiol | 19/1080 | 141/18723 | 4.81e-04 | 6.31e-03 | 19 |
GO:00064147 | Breast | Precancer | translational elongation | 10/1080 | 55/18723 | 1.06e-03 | 1.18e-02 | 10 |
GO:0035914 | Breast | Precancer | skeletal muscle cell differentiation | 11/1080 | 67/18723 | 1.47e-03 | 1.52e-02 | 11 |
GO:19900908 | Breast | Precancer | cellular response to nerve growth factor stimulus | 9/1080 | 53/18723 | 3.05e-03 | 2.62e-02 | 9 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:19900896 | Breast | Precancer | response to nerve growth factor | 9/1080 | 56/18723 | 4.47e-03 | 3.47e-02 | 9 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049218 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
hsa0492111 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa041524 | Colorectum | FAP | AMPK signaling pathway | 37/1404 | 121/8465 | 8.97e-05 | 8.56e-04 | 5.21e-04 | 37 |
hsa041525 | Colorectum | FAP | AMPK signaling pathway | 37/1404 | 121/8465 | 8.97e-05 | 8.56e-04 | 5.21e-04 | 37 |
hsa041526 | Colorectum | CRC | AMPK signaling pathway | 31/1091 | 121/8465 | 1.04e-04 | 1.57e-03 | 1.07e-03 | 31 |
hsa041527 | Colorectum | CRC | AMPK signaling pathway | 31/1091 | 121/8465 | 1.04e-04 | 1.57e-03 | 1.07e-03 | 31 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0415213 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa041528 | Liver | NAFLD | AMPK signaling pathway | 28/1043 | 121/8465 | 6.26e-04 | 9.78e-03 | 7.88e-03 | 28 |
hsa0415211 | Liver | NAFLD | AMPK signaling pathway | 28/1043 | 121/8465 | 6.26e-04 | 9.78e-03 | 7.88e-03 | 28 |
hsa0415221 | Liver | Cirrhotic | AMPK signaling pathway | 49/2530 | 121/8465 | 7.90e-03 | 2.74e-02 | 1.69e-02 | 49 |
hsa0415231 | Liver | Cirrhotic | AMPK signaling pathway | 49/2530 | 121/8465 | 7.90e-03 | 2.74e-02 | 1.69e-02 | 49 |
hsa0415241 | Liver | HCC | AMPK signaling pathway | 77/4020 | 121/8465 | 2.32e-04 | 1.11e-03 | 6.18e-04 | 77 |
hsa0415251 | Liver | HCC | AMPK signaling pathway | 77/4020 | 121/8465 | 2.32e-04 | 1.11e-03 | 6.18e-04 | 77 |
hsa04921 | Lung | IAC | Oxytocin signaling pathway | 33/1053 | 154/8465 | 1.09e-03 | 7.82e-03 | 5.19e-03 | 33 |
hsa049211 | Lung | IAC | Oxytocin signaling pathway | 33/1053 | 154/8465 | 1.09e-03 | 7.82e-03 | 5.19e-03 | 33 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EEF2 | SNV | Missense_Mutation | c.218N>T | p.Thr73Ile | p.T73I | P13639 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
EEF2 | SNV | Missense_Mutation | c.1471N>A | p.Ala491Thr | p.A491T | P13639 | protein_coding | deleterious(0) | benign(0.041) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EEF2 | SNV | Missense_Mutation | novel | c.104N>C | p.Leu35Pro | p.L35P | P13639 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EEF2 | SNV | Missense_Mutation | c.1421N>A | p.Gly474Asp | p.G474D | P13639 | protein_coding | deleterious(0.01) | benign(0.257) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EEF2 | SNV | Missense_Mutation | novel | c.752A>C | p.Lys251Thr | p.K251T | P13639 | protein_coding | deleterious(0) | benign(0.125) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EEF2 | deletion | Frame_Shift_Del | c.721delN | p.Glu241ArgfsTer13 | p.E241Rfs*13 | P13639 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
EEF2 | SNV | Missense_Mutation | novel | c.762G>T | p.Glu254Asp | p.E254D | P13639 | protein_coding | tolerated(0.53) | probably_damaging(0.973) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EEF2 | SNV | Missense_Mutation | novel | c.656A>G | p.His219Arg | p.H219R | P13639 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EEF2 | SNV | Missense_Mutation | c.1225N>T | p.Arg409Trp | p.R409W | P13639 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
EEF2 | SNV | Missense_Mutation | rs758884682 | c.2092C>T | p.Arg698Trp | p.R698W | P13639 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1938 | EEF2 | DRUGGABLE GENOME, KINASE | SS1(DSFV)-PE38 | |||
1938 | EEF2 | DRUGGABLE GENOME, KINASE | inhibitor | CHEMBL1201550 | DENILEUKIN DIFTITOX | |
1938 | EEF2 | DRUGGABLE GENOME, KINASE | VB4-845 | OPORTUZUMAB MONATOX | ||
1938 | EEF2 | DRUGGABLE GENOME, KINASE | LACTIMIDOMYCIN | LACTIMIDOMYCIN | 20118940 | |
1938 | EEF2 | DRUGGABLE GENOME, KINASE | CYCLOHEXIMIDE | CYCLOHEXIMIDE | 20118940 |
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