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Gene: EEF1G |
Gene summary for EEF1G |
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Gene information | Species | Human | Gene symbol | EEF1G | Gene ID | 1937 |
Gene name | eukaryotic translation elongation factor 1 gamma | |
Gene Alias | EF1G | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | P26641 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1937 | EEF1G | sample1 | Human | Cervix | CC | 3.40e-21 | 8.87e-01 | 0.0959 |
1937 | EEF1G | sample3 | Human | Cervix | CC | 5.03e-91 | 1.17e+00 | 0.1387 |
1937 | EEF1G | H2 | Human | Cervix | HSIL_HPV | 9.91e-61 | 1.06e+00 | 0.0632 |
1937 | EEF1G | L1 | Human | Cervix | CC | 7.52e-36 | 1.18e+00 | 0.0802 |
1937 | EEF1G | T1 | Human | Cervix | CC | 2.96e-23 | 6.68e-01 | 0.0918 |
1937 | EEF1G | T2 | Human | Cervix | CC | 1.68e-39 | 1.42e+00 | 0.0709 |
1937 | EEF1G | T3 | Human | Cervix | CC | 2.25e-94 | 1.17e+00 | 0.1389 |
1937 | EEF1G | AEH-subject1 | Human | Endometrium | AEH | 1.73e-38 | 8.64e-01 | -0.3059 |
1937 | EEF1G | AEH-subject2 | Human | Endometrium | AEH | 3.95e-43 | 1.01e+00 | -0.2525 |
1937 | EEF1G | AEH-subject3 | Human | Endometrium | AEH | 1.50e-62 | 1.18e+00 | -0.2576 |
1937 | EEF1G | AEH-subject4 | Human | Endometrium | AEH | 1.09e-40 | 9.92e-01 | -0.2657 |
1937 | EEF1G | AEH-subject5 | Human | Endometrium | AEH | 1.38e-39 | 8.62e-01 | -0.2953 |
1937 | EEF1G | EEC-subject1 | Human | Endometrium | EEC | 5.68e-62 | 1.22e+00 | -0.2682 |
1937 | EEF1G | EEC-subject2 | Human | Endometrium | EEC | 1.64e-55 | 1.04e+00 | -0.2607 |
1937 | EEF1G | EEC-subject3 | Human | Endometrium | EEC | 2.97e-42 | 1.18e+00 | -0.2525 |
1937 | EEF1G | EEC-subject4 | Human | Endometrium | EEC | 2.32e-63 | 1.15e+00 | -0.2571 |
1937 | EEF1G | EEC-subject5 | Human | Endometrium | EEC | 6.01e-65 | 1.26e+00 | -0.249 |
1937 | EEF1G | LZE11D | Human | Esophagus | HGIN | 8.80e-08 | 7.37e-01 | -0.005 |
1937 | EEF1G | LZE2D | Human | Esophagus | HGIN | 2.17e-18 | 2.51e+00 | 0.0642 |
1937 | EEF1G | LZE2T | Human | Esophagus | ESCC | 2.21e-25 | 3.06e+00 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00065755 | Cervix | HSIL_HPV | cellular modified amino acid metabolic process | 16/737 | 188/18723 | 3.18e-03 | 2.89e-02 | 16 |
GO:00067495 | Cervix | HSIL_HPV | glutathione metabolic process | 8/737 | 64/18723 | 3.51e-03 | 3.15e-02 | 8 |
GO:00064148 | Cervix | HSIL_HPV | translational elongation | 7/737 | 55/18723 | 5.59e-03 | 4.47e-02 | 7 |
GO:00096159 | Endometrium | AEH | response to virus | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:00064149 | Endometrium | AEH | translational elongation | 13/2100 | 55/18723 | 6.76e-03 | 3.94e-02 | 13 |
GO:000961513 | Endometrium | EEC | response to virus | 66/2168 | 367/18723 | 1.78e-04 | 2.20e-03 | 66 |
GO:000641414 | Endometrium | EEC | translational elongation | 13/2168 | 55/18723 | 8.79e-03 | 4.74e-02 | 13 |
GO:000641418 | Esophagus | HGIN | translational elongation | 22/2587 | 55/18723 | 1.46e-06 | 5.56e-05 | 22 |
GO:00067497 | Esophagus | HGIN | glutathione metabolic process | 20/2587 | 64/18723 | 2.63e-04 | 4.58e-03 | 20 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:000674912 | Esophagus | ESCC | glutathione metabolic process | 42/8552 | 64/18723 | 1.01e-03 | 5.12e-03 | 42 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:000657511 | Liver | Cirrhotic | cellular modified amino acid metabolic process | 70/4634 | 188/18723 | 9.04e-05 | 9.69e-04 | 70 |
GO:00067494 | Liver | Cirrhotic | glutathione metabolic process | 27/4634 | 64/18723 | 1.63e-03 | 1.05e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513416 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa0513417 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa0513423 | Cervix | HSIL_HPV | Legionellosis | 12/459 | 57/8465 | 4.24e-05 | 6.21e-04 | 5.02e-04 | 12 |
hsa0513433 | Cervix | HSIL_HPV | Legionellosis | 12/459 | 57/8465 | 4.24e-05 | 6.21e-04 | 5.02e-04 | 12 |
hsa0513418 | Endometrium | EEC | Legionellosis | 17/1237 | 57/8465 | 2.42e-03 | 1.47e-02 | 1.10e-02 | 17 |
hsa0513419 | Endometrium | EEC | Legionellosis | 17/1237 | 57/8465 | 2.42e-03 | 1.47e-02 | 1.10e-02 | 17 |
hsa0513427 | Esophagus | HGIN | Legionellosis | 18/1383 | 57/8465 | 3.20e-03 | 2.54e-02 | 2.02e-02 | 18 |
hsa05134112 | Esophagus | HGIN | Legionellosis | 18/1383 | 57/8465 | 3.20e-03 | 2.54e-02 | 2.02e-02 | 18 |
hsa0513428 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0513436 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0513412 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa0513413 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa0513425 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa05134111 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa0513443 | Oral cavity | EOLP | Legionellosis | 18/1218 | 57/8465 | 7.27e-04 | 2.73e-03 | 1.61e-03 | 18 |
hsa0513453 | Oral cavity | EOLP | Legionellosis | 18/1218 | 57/8465 | 7.27e-04 | 2.73e-03 | 1.61e-03 | 18 |
hsa0513461 | Oral cavity | NEOLP | Legionellosis | 15/1112 | 57/8465 | 5.58e-03 | 2.17e-02 | 1.36e-02 | 15 |
hsa0513471 | Oral cavity | NEOLP | Legionellosis | 15/1112 | 57/8465 | 5.58e-03 | 2.17e-02 | 1.36e-02 | 15 |
hsa0513420 | Prostate | BPH | Legionellosis | 22/1718 | 57/8465 | 1.10e-03 | 4.99e-03 | 3.09e-03 | 22 |
hsa05134110 | Prostate | BPH | Legionellosis | 22/1718 | 57/8465 | 1.10e-03 | 4.99e-03 | 3.09e-03 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EEF1G | SNV | Missense_Mutation | novel | c.413N>A | p.Ile138Asn | p.I138N | P26641 | protein_coding | tolerated(0.09) | benign(0.024) | TCGA-EY-A1GV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
EEF1G | deletion | Frame_Shift_Del | c.502delC | p.Leu168CysfsTer9 | p.L168Cfs*9 | P26641 | protein_coding | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
EEF1G | SNV | Missense_Mutation | novel | c.677N>T | p.Pro226Leu | p.P226L | P26641 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-2Y-A9H0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
EEF1G | SNV | Missense_Mutation | novel | c.871N>A | p.Asp291Asn | p.D291N | P26641 | protein_coding | deleterious(0.03) | benign(0.32) | TCGA-5C-AAPD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EEF1G | SNV | Missense_Mutation | c.533C>G | p.Pro178Arg | p.P178R | P26641 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-GJ-A6C0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EEF1G | SNV | Missense_Mutation | novel | c.26N>T | p.Tyr9Phe | p.Y9F | P26641 | protein_coding | tolerated(0.08) | benign(0.248) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
EEF1G | SNV | Missense_Mutation | novel | c.277N>T | p.Ala93Ser | p.A93S | P26641 | protein_coding | tolerated(0.22) | benign(0.081) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EEF1G | SNV | Missense_Mutation | novel | c.787N>C | p.Met263Leu | p.M263L | P26641 | protein_coding | tolerated(0.84) | benign(0) | TCGA-37-A5EL-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | temodal | PD |
EEF1G | SNV | Missense_Mutation | rs368954257 | c.98N>G | p.Ser33Cys | p.S33C | P26641 | protein_coding | tolerated(0.05) | benign(0.111) | TCGA-66-2794-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
EEF1G | insertion | Frame_Shift_Ins | novel | c.972_973insA | p.Glu325ArgfsTer6 | p.E325Rfs*6 | P26641 | protein_coding | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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