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Gene: EBPL |
Gene summary for EBPL |
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Gene information | Species | Human | Gene symbol | EBPL | Gene ID | 84650 |
Gene name | EBP like | |
Gene Alias | EBRP | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | A0A0A0MRV2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84650 | EBPL | HTA11_347_2000001011 | Human | Colorectum | AD | 1.37e-06 | 4.99e-01 | -0.1954 |
84650 | EBPL | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.20e-03 | 4.71e-01 | -0.059 |
84650 | EBPL | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.98e-18 | 1.08e+00 | 0.281 |
84650 | EBPL | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.64e-25 | 9.11e-01 | 0.3859 |
84650 | EBPL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.46e-05 | 4.08e-01 | 0.3005 |
84650 | EBPL | A015-C-203 | Human | Colorectum | FAP | 3.27e-07 | -1.89e-01 | -0.1294 |
84650 | EBPL | A002-C-201 | Human | Colorectum | FAP | 3.21e-03 | -1.45e-01 | 0.0324 |
84650 | EBPL | A001-C-108 | Human | Colorectum | FAP | 3.62e-02 | -1.07e-01 | -0.0272 |
84650 | EBPL | A002-C-205 | Human | Colorectum | FAP | 7.66e-07 | -2.04e-01 | -0.1236 |
84650 | EBPL | A002-C-114 | Human | Colorectum | FAP | 1.02e-08 | -2.44e-01 | -0.1561 |
84650 | EBPL | A015-C-104 | Human | Colorectum | FAP | 7.08e-08 | -1.76e-01 | -0.1899 |
84650 | EBPL | A001-C-014 | Human | Colorectum | FAP | 1.97e-02 | -1.41e-01 | 0.0135 |
84650 | EBPL | A002-C-016 | Human | Colorectum | FAP | 1.28e-04 | -1.59e-01 | 0.0521 |
84650 | EBPL | A015-C-002 | Human | Colorectum | FAP | 2.65e-05 | -2.44e-01 | -0.0763 |
84650 | EBPL | A002-C-116 | Human | Colorectum | FAP | 1.66e-05 | -1.48e-01 | -0.0452 |
84650 | EBPL | A018-E-020 | Human | Colorectum | FAP | 5.27e-05 | -1.85e-01 | -0.2034 |
84650 | EBPL | F034 | Human | Colorectum | FAP | 1.22e-02 | -1.20e-01 | -0.0665 |
84650 | EBPL | AEH-subject1 | Human | Endometrium | AEH | 3.56e-12 | -3.77e-01 | -0.3059 |
84650 | EBPL | AEH-subject2 | Human | Endometrium | AEH | 4.94e-22 | -4.97e-01 | -0.2525 |
84650 | EBPL | AEH-subject3 | Human | Endometrium | AEH | 4.49e-11 | -2.83e-01 | -0.2576 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:00161251 | Liver | Cirrhotic | sterol metabolic process | 75/4634 | 152/18723 | 4.54e-11 | 2.61e-09 | 75 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:00161252 | Liver | HCC | sterol metabolic process | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00161253 | Oral cavity | OSCC | sterol metabolic process | 77/7305 | 152/18723 | 2.26e-03 | 1.00e-02 | 77 |
GO:00082024 | Oral cavity | OSCC | steroid metabolic process | 146/7305 | 319/18723 | 7.78e-03 | 2.85e-02 | 146 |
GO:001612511 | Oral cavity | LP | sterol metabolic process | 51/4623 | 152/18723 | 8.57e-03 | 4.63e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | c.515_516delTT | p.Phe172Ter | p.F172* | Q9BY08 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delT | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
EBPL | deletion | Frame_Shift_Del | rs765134934 | c.516delN | p.Phe172LeufsTer7 | p.F172Lfs*7 | Q9BY08 | protein_coding | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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