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Gene: DYRK1A |
Gene summary for DYRK1A |
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Gene information | Species | Human | Gene symbol | DYRK1A | Gene ID | 1859 |
Gene name | dual specificity tyrosine phosphorylation regulated kinase 1A | |
Gene Alias | DYRK | |
Cytomap | 21q22.13 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q13627 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1859 | DYRK1A | CCI_1 | Human | Cervix | CC | 4.56e-17 | 1.32e+00 | 0.528 |
1859 | DYRK1A | CCI_2 | Human | Cervix | CC | 1.51e-13 | 1.86e+00 | 0.5249 |
1859 | DYRK1A | CCI_3 | Human | Cervix | CC | 6.46e-19 | 1.30e+00 | 0.516 |
1859 | DYRK1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.50e-34 | -8.55e-01 | 0.0155 |
1859 | DYRK1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.35e-06 | -5.81e-01 | -0.1808 |
1859 | DYRK1A | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.28e-05 | -8.21e-01 | 0.0216 |
1859 | DYRK1A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.64e-02 | -4.23e-01 | -0.1088 |
1859 | DYRK1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.82e-13 | -7.02e-01 | -0.1207 |
1859 | DYRK1A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.14e-16 | -5.71e-01 | -0.1464 |
1859 | DYRK1A | HTA11_866_2000001011 | Human | Colorectum | AD | 8.04e-15 | -5.70e-01 | -0.1001 |
1859 | DYRK1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.02e-06 | -6.60e-01 | -0.2061 |
1859 | DYRK1A | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.25e-06 | -5.86e-01 | -0.1462 |
1859 | DYRK1A | HTA11_546_2000001011 | Human | Colorectum | AD | 5.32e-05 | -6.20e-01 | -0.0842 |
1859 | DYRK1A | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.85e-02 | -7.33e-01 | -0.00410000000000005 |
1859 | DYRK1A | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.64e-10 | -8.13e-01 | -0.0179 |
1859 | DYRK1A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.44e-18 | -7.20e-01 | 0.096 |
1859 | DYRK1A | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.20e-03 | -6.60e-01 | 0.0446 |
1859 | DYRK1A | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.17e-02 | -8.66e-01 | 0.0451 |
1859 | DYRK1A | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.31e-06 | -6.98e-01 | 0.0528 |
1859 | DYRK1A | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.14e-05 | -5.38e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:003311910 | Cervix | CC | negative regulation of RNA splicing | 13/2311 | 25/18723 | 1.83e-06 | 5.89e-05 | 13 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:19029048 | Cervix | CC | negative regulation of supramolecular fiber organization | 40/2311 | 167/18723 | 2.39e-05 | 4.17e-04 | 40 |
GO:004802410 | Cervix | CC | regulation of mRNA splicing, via spliceosome | 28/2311 | 101/18723 | 2.41e-05 | 4.19e-04 | 28 |
GO:00313339 | Cervix | CC | negative regulation of protein-containing complex assembly | 35/2311 | 141/18723 | 3.41e-05 | 5.55e-04 | 35 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:007233110 | Cervix | CC | signal transduction by p53 class mediator | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:00182096 | Cervix | CC | peptidyl-serine modification | 66/2311 | 338/18723 | 9.58e-05 | 1.25e-03 | 66 |
GO:00506849 | Cervix | CC | regulation of mRNA processing | 33/2311 | 137/18723 | 1.06e-04 | 1.35e-03 | 33 |
GO:00514948 | Cervix | CC | negative regulation of cytoskeleton organization | 37/2311 | 163/18723 | 1.57e-04 | 1.88e-03 | 37 |
GO:20010209 | Cervix | CC | regulation of response to DNA damage stimulus | 46/2311 | 219/18723 | 1.92e-04 | 2.23e-03 | 46 |
GO:190331210 | Cervix | CC | negative regulation of mRNA metabolic process | 24/2311 | 92/18723 | 2.49e-04 | 2.77e-03 | 24 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DYRK1A | SNV | Missense_Mutation | novel | c.1906C>T | p.Pro636Ser | p.P636S | Q13627 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.968) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
DYRK1A | SNV | Missense_Mutation | c.804N>C | p.Gln268His | p.Q268H | Q13627 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DYRK1A | SNV | Missense_Mutation | c.919N>A | p.Asp307Asn | p.D307N | Q13627 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DYRK1A | SNV | Missense_Mutation | novel | c.1070G>T | p.Gly357Val | p.G357V | Q13627 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
DYRK1A | SNV | Missense_Mutation | c.467N>C | p.Met156Thr | p.M156T | Q13627 | protein_coding | tolerated(0.12) | benign(0.14) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DYRK1A | SNV | Missense_Mutation | novel | c.398N>A | p.Arg133Gln | p.R133Q | Q13627 | protein_coding | deleterious(0.03) | benign(0.194) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYRK1A | SNV | Missense_Mutation | novel | c.1339N>A | p.Ala447Thr | p.A447T | Q13627 | protein_coding | tolerated(0.13) | benign(0.117) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYRK1A | SNV | Missense_Mutation | c.478N>A | p.Glu160Lys | p.E160K | Q13627 | protein_coding | deleterious(0.04) | possibly_damaging(0.473) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DYRK1A | SNV | Missense_Mutation | rs757222616 | c.1675N>T | p.Arg559Cys | p.R559C | Q13627 | protein_coding | tolerated_low_confidence(0.14) | probably_damaging(0.973) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DYRK1A | SNV | Missense_Mutation | c.2138N>A | p.Gly713Asp | p.G713D | Q13627 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.992) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme1WO2011135259 | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme15-1 | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme6Pyrrolo[2,3-d]pyrimidines | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme23MPPDerivatives | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | inhibitor | 249565842 | ||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme13INDY | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | inhibitor | 405560505 | ||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme4Upper | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme12-3 | |||
1859 | DYRK1A | DRUGGABLE GENOME, KINASE, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | PMID28766366-Compound-Scheme18 |
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