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Gene: DUSP1 |
Gene summary for DUSP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DUSP1 | Gene ID | 1843 |
Gene name | dual specificity phosphatase 1 | |
Gene Alias | CL100 | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DU40 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1843 | DUSP1 | GSM4909281 | Human | Breast | IDC | 2.13e-09 | -4.87e-01 | 0.21 |
1843 | DUSP1 | GSM4909282 | Human | Breast | IDC | 9.71e-15 | 4.74e-01 | -0.0288 |
1843 | DUSP1 | GSM4909285 | Human | Breast | IDC | 2.33e-06 | -3.69e-01 | 0.21 |
1843 | DUSP1 | GSM4909286 | Human | Breast | IDC | 1.48e-23 | -7.16e-01 | 0.1081 |
1843 | DUSP1 | GSM4909290 | Human | Breast | IDC | 3.78e-18 | -7.68e-01 | 0.2096 |
1843 | DUSP1 | GSM4909291 | Human | Breast | IDC | 2.48e-08 | 4.85e-01 | 0.1753 |
1843 | DUSP1 | GSM4909294 | Human | Breast | IDC | 4.46e-09 | -3.00e-01 | 0.2022 |
1843 | DUSP1 | GSM4909296 | Human | Breast | IDC | 8.22e-11 | -4.66e-01 | 0.1524 |
1843 | DUSP1 | GSM4909297 | Human | Breast | IDC | 4.73e-19 | -1.06e-01 | 0.1517 |
1843 | DUSP1 | GSM4909299 | Human | Breast | IDC | 6.14e-14 | 4.64e-01 | 0.035 |
1843 | DUSP1 | GSM4909300 | Human | Breast | IDC | 4.32e-09 | 6.03e-01 | 0.0334 |
1843 | DUSP1 | GSM4909304 | Human | Breast | IDC | 4.03e-12 | -5.17e-01 | 0.1636 |
1843 | DUSP1 | GSM4909305 | Human | Breast | IDC | 3.53e-11 | 4.95e-01 | 0.0436 |
1843 | DUSP1 | GSM4909307 | Human | Breast | IDC | 1.21e-03 | -3.68e-01 | 0.1569 |
1843 | DUSP1 | GSM4909308 | Human | Breast | IDC | 7.51e-20 | 5.75e-01 | 0.158 |
1843 | DUSP1 | GSM4909311 | Human | Breast | IDC | 9.38e-37 | -5.69e-01 | 0.1534 |
1843 | DUSP1 | GSM4909312 | Human | Breast | IDC | 5.02e-08 | -3.25e-01 | 0.1552 |
1843 | DUSP1 | GSM4909313 | Human | Breast | IDC | 5.50e-03 | 3.23e-01 | 0.0391 |
1843 | DUSP1 | GSM4909315 | Human | Breast | IDC | 1.47e-11 | -5.06e-01 | 0.21 |
1843 | DUSP1 | GSM4909316 | Human | Breast | IDC | 2.45e-04 | -6.59e-01 | 0.21 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:000030214 | Breast | IDC | response to reactive oxygen species | 46/1434 | 222/18723 | 4.12e-10 | 4.59e-08 | 46 |
GO:003196013 | Breast | IDC | response to corticosteroid | 37/1434 | 167/18723 | 3.10e-09 | 2.63e-07 | 37 |
GO:004254213 | Breast | IDC | response to hydrogen peroxide | 32/1434 | 146/18723 | 4.65e-08 | 3.02e-06 | 32 |
GO:005138413 | Breast | IDC | response to glucocorticoid | 32/1434 | 148/18723 | 6.52e-08 | 4.07e-06 | 32 |
GO:005090011 | Breast | IDC | leukocyte migration | 54/1434 | 369/18723 | 3.10e-06 | 1.15e-04 | 54 |
GO:009752911 | Breast | IDC | myeloid leukocyte migration | 37/1434 | 220/18723 | 4.65e-06 | 1.62e-04 | 37 |
GO:003059511 | Breast | IDC | leukocyte chemotaxis | 38/1434 | 230/18723 | 5.36e-06 | 1.76e-04 | 38 |
GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
GO:003235512 | Breast | IDC | response to estradiol | 27/1434 | 141/18723 | 7.87e-06 | 2.35e-04 | 27 |
GO:006032611 | Breast | IDC | cell chemotaxis | 46/1434 | 310/18723 | 1.13e-05 | 3.08e-04 | 46 |
GO:190165414 | Breast | IDC | response to ketone | 33/1434 | 194/18723 | 1.17e-05 | 3.13e-04 | 33 |
GO:005159114 | Breast | IDC | response to cAMP | 20/1434 | 93/18723 | 2.00e-05 | 4.91e-04 | 20 |
GO:004668312 | Breast | IDC | response to organophosphorus | 24/1434 | 131/18723 | 5.22e-05 | 1.12e-03 | 24 |
GO:000268511 | Breast | IDC | regulation of leukocyte migration | 33/1434 | 210/18723 | 6.10e-05 | 1.27e-03 | 33 |
GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
GO:000268311 | Breast | IDC | negative regulation of immune system process | 55/1434 | 434/18723 | 1.53e-04 | 2.67e-03 | 55 |
GO:00512712 | Breast | IDC | negative regulation of cellular component movement | 48/1434 | 367/18723 | 1.88e-04 | 3.12e-03 | 48 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0541824 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0541834 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa05012110 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa05418110 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0501225 | Cervix | HSIL_HPV | Parkinson disease | 43/459 | 266/8465 | 6.69e-11 | 6.53e-09 | 5.28e-09 | 43 |
hsa0541825 | Cervix | HSIL_HPV | Fluid shear stress and atherosclerosis | 16/459 | 139/8465 | 3.41e-03 | 2.08e-02 | 1.68e-02 | 16 |
hsa0501235 | Cervix | HSIL_HPV | Parkinson disease | 43/459 | 266/8465 | 6.69e-11 | 6.53e-09 | 5.28e-09 | 43 |
hsa0541835 | Cervix | HSIL_HPV | Fluid shear stress and atherosclerosis | 16/459 | 139/8465 | 3.41e-03 | 2.08e-02 | 1.68e-02 | 16 |
hsa0501244 | Cervix | N_HPV | Parkinson disease | 45/349 | 266/8465 | 1.93e-16 | 1.75e-14 | 1.37e-14 | 45 |
hsa0541845 | Cervix | N_HPV | Fluid shear stress and atherosclerosis | 20/349 | 139/8465 | 9.29e-07 | 1.41e-05 | 1.10e-05 | 20 |
hsa0501254 | Cervix | N_HPV | Parkinson disease | 45/349 | 266/8465 | 1.93e-16 | 1.75e-14 | 1.37e-14 | 45 |
hsa0541855 | Cervix | N_HPV | Fluid shear stress and atherosclerosis | 20/349 | 139/8465 | 9.29e-07 | 1.41e-05 | 1.10e-05 | 20 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP1 | SNV | Missense_Mutation | rs770172254 | c.1027G>A | p.Val343Ile | p.V343I | P28562 | protein_coding | deleterious(0.02) | possibly_damaging(0.606) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
DUSP1 | SNV | Missense_Mutation | rs202068138 | c.973N>A | p.Ala325Thr | p.A325T | P28562 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DUSP1 | SNV | Missense_Mutation | c.1061T>C | p.Leu354Pro | p.L354P | P28562 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | Avastin+/-Tarceva | |||
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | HYDROXYUREA | HYDROXYUREA | 15856297 | |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | salbutamol | ALBUTEROL | 20673984 | |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | VASOPRESSIN | VASOPRESSIN | 9231829 | |
1843 | DUSP1 | PROTEIN PHOSPHATASE, KINASE, DRUGGABLE GENOME | ANTISENSE OLIGONUCLEOTIDES | 11988488 |
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