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Gene: DUS1L |
Gene summary for DUS1L |
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Gene information | Species | Human | Gene symbol | DUS1L | Gene ID | 64118 |
Gene name | dihydrouridine synthase 1 like | |
Gene Alias | DUS1 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0002943 | UniProtAcc | Q6P1R4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64118 | DUS1L | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.06e-05 | 4.86e-01 | -0.0811 |
64118 | DUS1L | HTA11_347_2000001011 | Human | Colorectum | AD | 4.79e-10 | 5.10e-01 | -0.1954 |
64118 | DUS1L | HTA11_696_2000001011 | Human | Colorectum | AD | 4.37e-09 | 4.61e-01 | -0.1464 |
64118 | DUS1L | HTA11_866_2000001011 | Human | Colorectum | AD | 2.52e-05 | 3.18e-01 | -0.1001 |
64118 | DUS1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.37e-15 | 7.91e-01 | -0.059 |
64118 | DUS1L | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.36e-04 | 7.00e-01 | -0.1706 |
64118 | DUS1L | HTA11_546_2000001011 | Human | Colorectum | AD | 1.12e-03 | 3.99e-01 | -0.0842 |
64118 | DUS1L | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.86e-02 | 4.33e-01 | -0.0179 |
64118 | DUS1L | HTA11_866_3004761011 | Human | Colorectum | AD | 1.06e-06 | 5.49e-01 | 0.096 |
64118 | DUS1L | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.79e-04 | 6.51e-01 | 0.0528 |
64118 | DUS1L | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.01e-05 | 9.27e-01 | 0.0171 |
64118 | DUS1L | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.60e-03 | 3.87e-01 | 0.0338 |
64118 | DUS1L | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.12e-11 | 4.97e-01 | 0.0674 |
64118 | DUS1L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.99e-09 | 5.20e-01 | 0.294 |
64118 | DUS1L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.01e-38 | 1.20e+00 | 0.3859 |
64118 | DUS1L | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.09e-05 | 7.18e-01 | 0.2585 |
64118 | DUS1L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.43e-48 | 1.19e+00 | 0.3005 |
64118 | DUS1L | A002-C-116 | Human | Colorectum | FAP | 1.59e-02 | -1.26e-01 | -0.0452 |
64118 | DUS1L | LZE7T | Human | Esophagus | ESCC | 1.44e-07 | 3.56e-01 | 0.0667 |
64118 | DUS1L | LZE20T | Human | Esophagus | ESCC | 2.59e-05 | 1.44e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUS1L | SNV | Missense_Mutation | novel | c.373N>C | p.Glu125Gln | p.E125Q | Q6P1R4 | protein_coding | deleterious(0.01) | possibly_damaging(0.862) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUS1L | SNV | Missense_Mutation | rs768534602 | c.529N>T | p.Arg177Cys | p.R177C | Q6P1R4 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-V1-A9OL-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DUS1L | SNV | Missense_Mutation | novel | c.1273N>T | p.Asp425Tyr | p.D425Y | Q6P1R4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DUS1L | SNV | Missense_Mutation | rs768534602 | c.529N>T | p.Arg177Cys | p.R177C | Q6P1R4 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
DUS1L | SNV | Missense_Mutation | rs138475537 | c.1067G>A | p.Arg356Gln | p.R356Q | Q6P1R4 | protein_coding | deleterious(0.03) | possibly_damaging(0.89) | TCGA-D7-6525-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | PD | |
DUS1L | SNV | Missense_Mutation | rs376659580 | c.1253N>A | p.Arg418Gln | p.R418Q | Q6P1R4 | protein_coding | deleterious(0.05) | benign(0.025) | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
DUS1L | SNV | Missense_Mutation | c.526G>A | p.Gly176Arg | p.G176R | Q6P1R4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F1-A448-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
DUS1L | SNV | Missense_Mutation | rs778657338 | c.593N>A | p.Arg198Gln | p.R198Q | Q6P1R4 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
DUS1L | SNV | Missense_Mutation | novel | c.463N>C | p.Asp155His | p.D155H | Q6P1R4 | protein_coding | deleterious(0.01) | possibly_damaging(0.601) | TCGA-IN-A6RS-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUS1L | SNV | Missense_Mutation | novel | c.665G>T | p.Arg222Leu | p.R222L | Q6P1R4 | protein_coding | tolerated(0.07) | benign(0.112) | TCGA-DE-A0XZ-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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