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Gene: DUOX2 |
Gene summary for DUOX2 |
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Gene information | Species | Human | Gene symbol | DUOX2 | Gene ID | 50506 |
Gene name | dual oxidase 2 | |
Gene Alias | LNOX2 | |
Cytomap | 15q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006575 | UniProtAcc | Q9NRD8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50506 | DUOX2 | CCII_1 | Human | Cervix | CC | 3.08e-20 | 6.00e-01 | 0.3249 |
50506 | DUOX2 | Tumor | Human | Cervix | CC | 1.59e-22 | 5.63e-01 | 0.1241 |
50506 | DUOX2 | sample3 | Human | Cervix | CC | 3.26e-47 | 8.19e-01 | 0.1387 |
50506 | DUOX2 | H2 | Human | Cervix | HSIL_HPV | 4.82e-25 | 7.35e-01 | 0.0632 |
50506 | DUOX2 | T3 | Human | Cervix | CC | 1.65e-49 | 8.42e-01 | 0.1389 |
50506 | DUOX2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.75e-16 | 5.71e-01 | -0.0811 |
50506 | DUOX2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.01e-10 | 2.52e+00 | -0.2602 |
50506 | DUOX2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.64e-25 | 1.27e+00 | -0.059 |
50506 | DUOX2 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.37e-11 | 6.16e-01 | 0.096 |
50506 | DUOX2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.21e-04 | 2.98e-01 | 0.0674 |
50506 | DUOX2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.01e-06 | 5.39e-01 | 0.0112 |
50506 | DUOX2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.77e-20 | 9.12e-01 | 0.0588 |
50506 | DUOX2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.67e-07 | 5.32e-01 | 0.2585 |
50506 | DUOX2 | A002-C-010 | Human | Colorectum | FAP | 7.88e-04 | 3.46e-01 | 0.242 |
50506 | DUOX2 | A001-C-207 | Human | Colorectum | FAP | 1.17e-02 | 3.10e-01 | 0.1278 |
50506 | DUOX2 | A002-C-201 | Human | Colorectum | FAP | 3.68e-20 | 7.45e-01 | 0.0324 |
50506 | DUOX2 | A002-C-203 | Human | Colorectum | FAP | 9.53e-13 | 5.40e-01 | 0.2786 |
50506 | DUOX2 | A001-C-108 | Human | Colorectum | FAP | 4.25e-02 | 3.15e-01 | -0.0272 |
50506 | DUOX2 | A002-C-021 | Human | Colorectum | FAP | 5.09e-15 | 4.69e-01 | 0.1171 |
50506 | DUOX2 | A015-C-005 | Human | Colorectum | FAP | 5.56e-04 | 3.17e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00610418 | Cervix | CC | regulation of wound healing | 34/2311 | 134/18723 | 2.70e-05 | 4.52e-04 | 34 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
GO:00972379 | Cervix | CC | cellular response to toxic substance | 31/2311 | 124/18723 | 8.09e-05 | 1.10e-03 | 31 |
GO:19030368 | Cervix | CC | positive regulation of response to wounding | 21/2311 | 72/18723 | 1.10e-04 | 1.39e-03 | 21 |
GO:00903037 | Cervix | CC | positive regulation of wound healing | 18/2311 | 59/18723 | 1.78e-04 | 2.09e-03 | 18 |
GO:00192213 | Cervix | CC | cytokine-mediated signaling pathway | 84/2311 | 472/18723 | 3.25e-04 | 3.44e-03 | 84 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00725939 | Cervix | CC | reactive oxygen species metabolic process | 47/2311 | 239/18723 | 7.74e-04 | 6.87e-03 | 47 |
GO:00987549 | Cervix | CC | detoxification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:005159110 | Cervix | CC | response to cAMP | 21/2311 | 93/18723 | 4.10e-03 | 2.54e-02 | 21 |
GO:0006801 | Cervix | CC | superoxide metabolic process | 17/2311 | 74/18723 | 7.73e-03 | 4.10e-02 | 17 |
GO:00427438 | Cervix | CC | hydrogen peroxide metabolic process | 14/2311 | 58/18723 | 9.57e-03 | 4.73e-02 | 14 |
GO:19034095 | Cervix | CC | reactive oxygen species biosynthetic process | 15/2311 | 64/18723 | 9.89e-03 | 4.85e-02 | 15 |
GO:000697915 | Cervix | HSIL_HPV | response to oxidative stress | 48/737 | 446/18723 | 2.76e-10 | 7.02e-08 | 48 |
GO:004206015 | Cervix | HSIL_HPV | wound healing | 40/737 | 422/18723 | 2.80e-07 | 1.61e-05 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUOX2 | SNV | Missense_Mutation | rs367803824 | c.3163G>A | p.Val1055Met | p.V1055M | Q9NRD8 | protein_coding | deleterious(0) | benign(0.19) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DUOX2 | SNV | Missense_Mutation | c.1795N>A | p.Ala599Thr | p.A599T | Q9NRD8 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DUOX2 | SNV | Missense_Mutation | rs759249545 | c.2806N>T | p.Arg936Cys | p.R936C | Q9NRD8 | protein_coding | deleterious(0.01) | possibly_damaging(0.856) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
DUOX2 | SNV | Missense_Mutation | c.2640C>A | p.Phe880Leu | p.F880L | Q9NRD8 | protein_coding | deleterious(0.01) | possibly_damaging(0.823) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DUOX2 | SNV | Missense_Mutation | c.2810N>A | p.Phe937Tyr | p.F937Y | Q9NRD8 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
DUOX2 | SNV | Missense_Mutation | rs527361236 | c.893N>C | p.Val298Ala | p.V298A | Q9NRD8 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DUOX2 | SNV | Missense_Mutation | c.3929N>C | p.Leu1310Pro | p.L1310P | Q9NRD8 | protein_coding | deleterious(0.03) | benign(0.333) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DUOX2 | SNV | Missense_Mutation | rs144886975 | c.3646C>T | p.Arg1216Trp | p.R1216W | Q9NRD8 | protein_coding | deleterious(0.02) | possibly_damaging(0.901) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DUOX2 | SNV | Missense_Mutation | c.4128N>T | p.Lys1376Asn | p.K1376N | Q9NRD8 | protein_coding | deleterious(0.01) | benign(0.145) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DUOX2 | SNV | Missense_Mutation | c.436N>A | p.Gly146Arg | p.G146R | Q9NRD8 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
50506 | DUOX2 | TRANSPORTER, ENZYME, DRUGGABLE GENOME, CELL SURFACE | inhibitor | 363894227 |
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