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Gene: DLX5 |
Gene summary for DLX5 |
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Gene information | Species | Human | Gene symbol | DLX5 | Gene ID | 1749 |
Gene name | distal-less homeobox 5 | |
Gene Alias | SHFM1 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P56178 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1749 | DLX5 | LZE2T | Human | Esophagus | ESCC | 4.39e-03 | 4.57e-01 | 0.082 |
1749 | DLX5 | LZE4T | Human | Esophagus | ESCC | 8.51e-04 | 4.15e-01 | 0.0811 |
1749 | DLX5 | LZE7T | Human | Esophagus | ESCC | 6.10e-07 | 7.03e-01 | 0.0667 |
1749 | DLX5 | LZE21D1 | Human | Esophagus | HGIN | 3.51e-04 | 3.54e-01 | 0.0632 |
1749 | DLX5 | LZE22T | Human | Esophagus | ESCC | 1.16e-04 | 8.09e-01 | 0.068 |
1749 | DLX5 | LZE24T | Human | Esophagus | ESCC | 1.33e-04 | 2.51e-01 | 0.0596 |
1749 | DLX5 | LZE21T | Human | Esophagus | ESCC | 2.27e-07 | 5.95e-01 | 0.0655 |
1749 | DLX5 | P2T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.78e-01 | 0.1177 |
1749 | DLX5 | P4T-E | Human | Esophagus | ESCC | 2.55e-28 | 7.60e-01 | 0.1323 |
1749 | DLX5 | P5T-E | Human | Esophagus | ESCC | 4.41e-07 | 2.04e-01 | 0.1327 |
1749 | DLX5 | P9T-E | Human | Esophagus | ESCC | 1.49e-27 | 8.34e-01 | 0.1131 |
1749 | DLX5 | P10T-E | Human | Esophagus | ESCC | 2.85e-73 | 1.45e+00 | 0.116 |
1749 | DLX5 | P11T-E | Human | Esophagus | ESCC | 6.76e-10 | 8.18e-01 | 0.1426 |
1749 | DLX5 | P12T-E | Human | Esophagus | ESCC | 1.77e-86 | 1.87e+00 | 0.1122 |
1749 | DLX5 | P15T-E | Human | Esophagus | ESCC | 5.54e-69 | 2.11e+00 | 0.1149 |
1749 | DLX5 | P16T-E | Human | Esophagus | ESCC | 1.85e-55 | 1.21e+00 | 0.1153 |
1749 | DLX5 | P20T-E | Human | Esophagus | ESCC | 5.96e-07 | 2.30e-01 | 0.1124 |
1749 | DLX5 | P22T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.81e-01 | 0.1236 |
1749 | DLX5 | P23T-E | Human | Esophagus | ESCC | 2.38e-14 | 4.77e-01 | 0.108 |
1749 | DLX5 | P24T-E | Human | Esophagus | ESCC | 1.97e-10 | 3.27e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000164917 | Esophagus | HGIN | osteoblast differentiation | 50/2587 | 229/18723 | 5.88e-04 | 8.30e-03 | 50 |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:009026310 | Esophagus | HGIN | positive regulation of canonical Wnt signaling pathway | 26/2587 | 106/18723 | 2.17e-03 | 2.25e-02 | 26 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:003017710 | Esophagus | HGIN | positive regulation of Wnt signaling pathway | 31/2587 | 140/18723 | 4.77e-03 | 4.09e-02 | 31 |
GO:006082816 | Esophagus | HGIN | regulation of canonical Wnt signaling pathway | 50/2587 | 253/18723 | 5.27e-03 | 4.35e-02 | 50 |
GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00603242 | Esophagus | ESCC | face development | 34/8552 | 44/18723 | 1.90e-05 | 1.67e-04 | 34 |
GO:009026316 | Esophagus | ESCC | positive regulation of canonical Wnt signaling pathway | 69/8552 | 106/18723 | 4.22e-05 | 3.39e-04 | 69 |
GO:003017716 | Esophagus | ESCC | positive regulation of Wnt signaling pathway | 87/8552 | 140/18723 | 6.18e-05 | 4.73e-04 | 87 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLX5 | SNV | Missense_Mutation | novel | c.812T>A | p.Leu271Gln | p.L271Q | P56178 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DLX5 | SNV | Missense_Mutation | rs762498461 | c.824N>A | p.Gly275Asp | p.G275D | P56178 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-DD-AADR-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
DLX5 | SNV | Missense_Mutation | c.388N>A | p.Val130Met | p.V130M | P56178 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DLX5 | SNV | Missense_Mutation | novel | c.248C>A | p.Ser83Tyr | p.S83Y | P56178 | protein_coding | tolerated(0.06) | possibly_damaging(0.905) | TCGA-WJ-A86L-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DLX5 | SNV | Missense_Mutation | c.388N>T | p.Val130Leu | p.V130L | P56178 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLX5 | SNV | Missense_Mutation | c.387N>T | p.Met129Ile | p.M129I | P56178 | protein_coding | tolerated(0.32) | benign(0.015) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLX5 | SNV | Missense_Mutation | c.689C>G | p.Ser230Cys | p.S230C | P56178 | protein_coding | deleterious(0.01) | benign(0.174) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
DLX5 | SNV | Missense_Mutation | novel | c.284A>G | p.Tyr95Cys | p.Y95C | P56178 | protein_coding | deleterious(0.01) | possibly_damaging(0.886) | TCGA-55-8299-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DLX5 | SNV | Missense_Mutation | c.18N>A | p.Asp6Glu | p.D6E | P56178 | protein_coding | tolerated(0.37) | benign(0.043) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLX5 | SNV | Missense_Mutation | novel | c.595N>T | p.Gly199Trp | p.G199W | P56178 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-80-5608-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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