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Gene: DLGAP1 |
Gene summary for DLGAP1 |
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Gene information | Species | Human | Gene symbol | DLGAP1 | Gene ID | 9229 |
Gene name | DLG associated protein 1 | |
Gene Alias | DAP-1 | |
Cytomap | 18p11.31 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O14490 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9229 | DLGAP1 | AEH-subject5 | Human | Endometrium | AEH | 2.67e-02 | 2.88e-01 | -0.2953 |
9229 | DLGAP1 | EEC-subject1 | Human | Endometrium | EEC | 1.85e-06 | 3.16e-01 | -0.2682 |
9229 | DLGAP1 | EEC-subject3 | Human | Endometrium | EEC | 2.17e-04 | 3.12e-01 | -0.2525 |
9229 | DLGAP1 | EEC-subject5 | Human | Endometrium | EEC | 1.42e-03 | 2.64e-01 | -0.249 |
9229 | DLGAP1 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 1.88e-01 | 0.0667 |
9229 | DLGAP1 | P2T-E | Human | Esophagus | ESCC | 2.13e-23 | 5.08e-01 | 0.1177 |
9229 | DLGAP1 | P5T-E | Human | Esophagus | ESCC | 8.06e-15 | 3.58e-01 | 0.1327 |
9229 | DLGAP1 | P10T-E | Human | Esophagus | ESCC | 1.74e-13 | 2.08e-01 | 0.116 |
9229 | DLGAP1 | P12T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.53e-01 | 0.1122 |
9229 | DLGAP1 | P16T-E | Human | Esophagus | ESCC | 4.10e-10 | 2.44e-01 | 0.1153 |
9229 | DLGAP1 | P22T-E | Human | Esophagus | ESCC | 2.13e-04 | 6.94e-02 | 0.1236 |
9229 | DLGAP1 | P23T-E | Human | Esophagus | ESCC | 1.14e-03 | 1.42e-01 | 0.108 |
9229 | DLGAP1 | P26T-E | Human | Esophagus | ESCC | 2.96e-24 | 5.27e-01 | 0.1276 |
9229 | DLGAP1 | P27T-E | Human | Esophagus | ESCC | 8.54e-66 | 1.06e+00 | 0.1055 |
9229 | DLGAP1 | P32T-E | Human | Esophagus | ESCC | 1.25e-10 | 3.00e-01 | 0.1666 |
9229 | DLGAP1 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.12e-01 | 0.1371 |
9229 | DLGAP1 | P39T-E | Human | Esophagus | ESCC | 6.38e-08 | 2.00e-01 | 0.0894 |
9229 | DLGAP1 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.79e-01 | 0.1175 |
9229 | DLGAP1 | P54T-E | Human | Esophagus | ESCC | 6.60e-44 | 1.19e+00 | 0.0975 |
9229 | DLGAP1 | P57T-E | Human | Esophagus | ESCC | 8.15e-09 | 2.67e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLGAP1 | SNV | Missense_Mutation | c.2594N>A | p.Pro865His | p.P865H | O14490 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DLGAP1 | SNV | Missense_Mutation | rs562356088 | c.2495N>A | p.Arg832Gln | p.R832Q | O14490 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | rs755948170 | c.1907N>T | p.Thr636Met | p.T636M | O14490 | protein_coding | tolerated(0.07) | benign(0.132) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DLGAP1 | SNV | Missense_Mutation | c.1019N>A | p.Arg340Gln | p.R340Q | O14490 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | c.1153N>G | p.Thr385Ala | p.T385A | O14490 | protein_coding | tolerated(0.23) | benign(0.082) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | c.172N>A | p.Val58Met | p.V58M | O14490 | protein_coding | tolerated(1) | benign(0.007) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | c.1062N>C | p.Glu354Asp | p.E354D | O14490 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | c.1822G>A | p.Ala608Thr | p.A608T | O14490 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | c.1273N>T | p.Pro425Ser | p.P425S | O14490 | protein_coding | tolerated(0.29) | benign(0.028) | TCGA-F4-6854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLGAP1 | SNV | Missense_Mutation | rs761130306 | c.518N>T | p.Ala173Val | p.A173V | O14490 | protein_coding | tolerated(0.13) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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