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Gene: DLG5 |
Gene summary for DLG5 |
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Gene information | Species | Human | Gene symbol | DLG5 | Gene ID | 9231 |
Gene name | discs large MAGUK scaffold protein 5 | |
Gene Alias | LP-DLG | |
Cytomap | 10q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q8TDM6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9231 | DLG5 | GSM4909302 | Human | Breast | IDC | 4.18e-11 | 5.47e-01 | 0.1545 |
9231 | DLG5 | GSM4909304 | Human | Breast | IDC | 2.83e-35 | 7.45e-01 | 0.1636 |
9231 | DLG5 | GSM4909308 | Human | Breast | IDC | 4.06e-05 | 3.90e-01 | 0.158 |
9231 | DLG5 | GSM4909311 | Human | Breast | IDC | 1.03e-08 | 1.91e-02 | 0.1534 |
9231 | DLG5 | GSM4909319 | Human | Breast | IDC | 7.13e-17 | 3.01e-01 | 0.1563 |
9231 | DLG5 | GSM4909321 | Human | Breast | IDC | 2.12e-02 | -9.39e-03 | 0.1559 |
9231 | DLG5 | DCIS2 | Human | Breast | DCIS | 4.03e-73 | 6.10e-01 | 0.0085 |
9231 | DLG5 | CA_HPV_1 | Human | Cervix | CC | 9.81e-05 | -1.46e-01 | 0.0264 |
9231 | DLG5 | CCI_1 | Human | Cervix | CC | 1.93e-07 | 1.00e+00 | 0.528 |
9231 | DLG5 | CCI_2 | Human | Cervix | CC | 9.37e-06 | 8.02e-01 | 0.5249 |
9231 | DLG5 | sample3 | Human | Cervix | CC | 4.61e-07 | 2.83e-01 | 0.1387 |
9231 | DLG5 | T3 | Human | Cervix | CC | 4.72e-06 | 2.62e-01 | 0.1389 |
9231 | DLG5 | LZE5T | Human | Esophagus | ESCC | 1.94e-03 | 2.77e-01 | 0.0514 |
9231 | DLG5 | LZE8T | Human | Esophagus | ESCC | 1.23e-03 | 1.15e-01 | 0.067 |
9231 | DLG5 | LZE22T | Human | Esophagus | ESCC | 1.24e-05 | 3.30e-01 | 0.068 |
9231 | DLG5 | LZE24T | Human | Esophagus | ESCC | 1.24e-09 | 2.38e-01 | 0.0596 |
9231 | DLG5 | P1T-E | Human | Esophagus | ESCC | 7.68e-04 | 3.13e-01 | 0.0875 |
9231 | DLG5 | P2T-E | Human | Esophagus | ESCC | 1.26e-14 | 2.72e-01 | 0.1177 |
9231 | DLG5 | P4T-E | Human | Esophagus | ESCC | 8.98e-09 | 7.10e-02 | 0.1323 |
9231 | DLG5 | P5T-E | Human | Esophagus | ESCC | 1.47e-11 | 8.32e-02 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003090112 | Breast | IDC | midbrain development | 24/1434 | 90/18723 | 4.35e-08 | 2.87e-06 | 24 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:005086311 | Breast | IDC | regulation of T cell activation | 47/1434 | 329/18723 | 2.49e-05 | 5.91e-04 | 47 |
GO:000715912 | Breast | IDC | leukocyte cell-cell adhesion | 49/1434 | 371/18723 | 1.27e-04 | 2.33e-03 | 49 |
GO:000268311 | Breast | IDC | negative regulation of immune system process | 55/1434 | 434/18723 | 1.53e-04 | 2.67e-03 | 55 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:190303711 | Breast | IDC | regulation of leukocyte cell-cell adhesion | 45/1434 | 336/18723 | 1.72e-04 | 2.92e-03 | 45 |
GO:00512712 | Breast | IDC | negative regulation of cellular component movement | 48/1434 | 367/18723 | 1.88e-04 | 3.12e-03 | 48 |
GO:00303244 | Breast | IDC | lung development | 28/1434 | 177/18723 | 1.90e-04 | 3.15e-03 | 28 |
GO:00303234 | Breast | IDC | respiratory tube development | 28/1434 | 181/18723 | 2.78e-04 | 4.26e-03 | 28 |
GO:000716314 | Breast | IDC | establishment or maintenance of cell polarity | 32/1434 | 218/18723 | 2.84e-04 | 4.33e-03 | 32 |
GO:00611383 | Breast | IDC | morphogenesis of a branching epithelium | 28/1434 | 182/18723 | 3.05e-04 | 4.60e-03 | 28 |
GO:002240712 | Breast | IDC | regulation of cell-cell adhesion | 55/1434 | 448/18723 | 3.43e-04 | 5.07e-03 | 55 |
GO:00605412 | Breast | IDC | respiratory system development | 30/1434 | 203/18723 | 3.85e-04 | 5.40e-03 | 30 |
GO:20001462 | Breast | IDC | negative regulation of cell motility | 46/1434 | 359/18723 | 4.01e-04 | 5.60e-03 | 46 |
GO:00017635 | Breast | IDC | morphogenesis of a branching structure | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:0001656 | Breast | IDC | metanephros development | 16/1434 | 85/18723 | 6.49e-04 | 8.04e-03 | 16 |
GO:00303362 | Breast | IDC | negative regulation of cell migration | 43/1434 | 344/18723 | 1.01e-03 | 1.13e-02 | 43 |
GO:004209812 | Breast | IDC | T cell proliferation | 28/1434 | 199/18723 | 1.29e-03 | 1.35e-02 | 28 |
GO:0034333 | Breast | IDC | adherens junction assembly | 5/1434 | 12/18723 | 1.31e-03 | 1.37e-02 | 5 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439010 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa0439015 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa0439024 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
hsa0439034 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLG5 | SNV | Missense_Mutation | novel | c.1289G>A | p.Ser430Asn | p.S430N | Q8TDM6 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DLG5 | SNV | Missense_Mutation | novel | c.3428N>T | p.Gly1143Val | p.G1143V | Q8TDM6 | protein_coding | tolerated(0.11) | benign(0.012) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DLG5 | SNV | Missense_Mutation | c.670G>A | p.Asp224Asn | p.D224N | Q8TDM6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
DLG5 | SNV | Missense_Mutation | novel | c.1633G>C | p.Asp545His | p.D545H | Q8TDM6 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DLG5 | SNV | Missense_Mutation | c.5585C>T | p.Thr1862Ile | p.T1862I | Q8TDM6 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DLG5 | SNV | Missense_Mutation | rs374686972 | c.1406N>T | p.Ala469Val | p.A469V | Q8TDM6 | protein_coding | tolerated(0.95) | benign(0.006) | TCGA-MY-A5BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DLG5 | SNV | Missense_Mutation | c.4468G>C | p.Ala1490Pro | p.A1490P | Q8TDM6 | protein_coding | tolerated(1) | benign(0) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
DLG5 | SNV | Missense_Mutation | c.1315C>T | p.Arg439Cys | p.R439C | Q8TDM6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
DLG5 | SNV | Missense_Mutation | c.2248N>A | p.Ala750Thr | p.A750T | Q8TDM6 | protein_coding | deleterious(0.03) | benign(0.301) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DLG5 | SNV | Missense_Mutation | c.4069N>C | p.Ser1357Pro | p.S1357P | Q8TDM6 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9231 | DLG5 | KINASE | capecitabine | CAPECITABINE | ||
9231 | DLG5 | KINASE | fluorouracil | FLUOROURACIL |
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