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Gene: DEPDC1B |
Gene summary for DEPDC1B |
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Gene information | Species | Human | Gene symbol | DEPDC1B | Gene ID | 55789 |
Gene name | DEP domain containing 1B | |
Gene Alias | BRCC3 | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q8WUY9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55789 | DEPDC1B | HCC1_Meng | Human | Liver | HCC | 7.43e-33 | 5.55e-02 | 0.0246 |
55789 | DEPDC1B | S027 | Human | Liver | HCC | 3.57e-02 | 4.50e-01 | 0.2446 |
55789 | DEPDC1B | S028 | Human | Liver | HCC | 6.02e-11 | 5.42e-01 | 0.2503 |
55789 | DEPDC1B | S029 | Human | Liver | HCC | 3.50e-13 | 9.89e-01 | 0.2581 |
55789 | DEPDC1B | P5_S10_cSCC | Human | Skin | cSCC | 1.79e-02 | 7.20e-02 | -0.299 |
55789 | DEPDC1B | P4_cSCC | Human | Skin | cSCC | 3.67e-13 | 2.89e-01 | -0.00290000000000005 |
55789 | DEPDC1B | P10_cSCC | Human | Skin | cSCC | 5.14e-10 | 5.04e-01 | 0.1017 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
GO:001605524 | Skin | cSCC | Wnt signaling pathway | 158/4864 | 444/18723 | 3.80e-06 | 5.70e-05 | 158 |
GO:019873824 | Skin | cSCC | cell-cell signaling by wnt | 158/4864 | 446/18723 | 5.08e-06 | 7.38e-05 | 158 |
GO:003011124 | Skin | cSCC | regulation of Wnt signaling pathway | 117/4864 | 328/18723 | 5.80e-05 | 5.75e-04 | 117 |
GO:003017724 | Skin | cSCC | positive regulation of Wnt signaling pathway | 55/4864 | 140/18723 | 3.72e-04 | 2.92e-03 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEPDC1B | SNV | Missense_Mutation | rs752619351 | c.1583G>A | p.Arg528Gln | p.R528Q | Q8WUY9 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | rs201451342 | c.641C>T | p.Ser214Leu | p.S214L | Q8WUY9 | protein_coding | deleterious(0) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | novel | c.956N>C | p.Leu319Pro | p.L319P | Q8WUY9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | novel | c.912G>T | p.Lys304Asn | p.K304N | Q8WUY9 | protein_coding | tolerated(0.41) | benign(0.051) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | novel | c.971N>T | p.Arg324Met | p.R324M | Q8WUY9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | rs201451342 | c.641C>T | p.Ser214Leu | p.S214L | Q8WUY9 | protein_coding | deleterious(0) | benign(0.003) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | rs377727476 | c.1216N>T | p.Arg406Cys | p.R406C | Q8WUY9 | protein_coding | deleterious(0) | possibly_damaging(0.676) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC1B | SNV | Missense_Mutation | novel | c.385N>T | p.Pro129Ser | p.P129S | Q8WUY9 | protein_coding | tolerated(0.41) | benign(0.015) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DEPDC1B | SNV | Missense_Mutation | rs754296817 | c.61N>A | p.Val21Met | p.V21M | Q8WUY9 | protein_coding | deleterious(0.02) | benign(0.183) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DEPDC1B | deletion | Frame_Shift_Del | novel | c.234delN | p.Lys78AsnfsTer3 | p.K78Nfs*3 | Q8WUY9 | protein_coding | TCGA-BG-A0LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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