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Gene: DENND4A |
Gene summary for DENND4A |
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Gene information | Species | Human | Gene symbol | DENND4A | Gene ID | 10260 |
Gene name | DENN domain containing 4A | |
Gene Alias | IRLB | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05C90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10260 | DENND4A | CCI_2 | Human | Cervix | CC | 2.95e-19 | 1.96e+00 | 0.5249 |
10260 | DENND4A | CCI_3 | Human | Cervix | CC | 5.71e-06 | 6.21e-01 | 0.516 |
10260 | DENND4A | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.95e-17 | -6.06e-01 | 0.0155 |
10260 | DENND4A | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.07e-10 | -6.50e-01 | -0.1808 |
10260 | DENND4A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.28e-03 | -4.62e-01 | -0.1088 |
10260 | DENND4A | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.45e-06 | -5.92e-01 | -0.1207 |
10260 | DENND4A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.01e-22 | -5.78e-01 | -0.1464 |
10260 | DENND4A | HTA11_866_2000001011 | Human | Colorectum | AD | 1.21e-21 | -5.90e-01 | -0.1001 |
10260 | DENND4A | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.85e-02 | -6.57e-01 | -0.1706 |
10260 | DENND4A | HTA11_546_2000001011 | Human | Colorectum | AD | 2.16e-02 | -5.64e-01 | -0.0842 |
10260 | DENND4A | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.83e-05 | -7.12e-01 | -0.0179 |
10260 | DENND4A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.75e-17 | -6.88e-01 | 0.096 |
10260 | DENND4A | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.09e-02 | -6.33e-01 | 0.0528 |
10260 | DENND4A | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.98e-08 | -6.30e-01 | 0.0338 |
10260 | DENND4A | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.45e-16 | -5.39e-01 | 0.0674 |
10260 | DENND4A | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.96e-06 | -6.24e-01 | 0.0588 |
10260 | DENND4A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.79e-24 | -6.11e-01 | 0.294 |
10260 | DENND4A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.90e-04 | -5.27e-01 | 0.281 |
10260 | DENND4A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.55e-20 | -5.70e-01 | 0.3859 |
10260 | DENND4A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.48e-07 | -6.99e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00465781 | Colorectum | FAP | regulation of Ras protein signal transduction | 47/2622 | 189/18723 | 4.67e-05 | 9.60e-04 | 47 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:00072653 | Colorectum | CRC | Ras protein signal transduction | 70/2078 | 337/18723 | 1.49e-07 | 1.66e-05 | 70 |
GO:00465782 | Colorectum | CRC | regulation of Ras protein signal transduction | 43/2078 | 189/18723 | 3.26e-06 | 1.47e-04 | 43 |
GO:00510567 | Endometrium | AEH | regulation of small GTPase mediated signal transduction | 59/2100 | 302/18723 | 1.43e-05 | 3.03e-04 | 59 |
GO:00072657 | Endometrium | AEH | Ras protein signal transduction | 63/2100 | 337/18723 | 3.09e-05 | 5.66e-04 | 63 |
GO:00465786 | Endometrium | AEH | regulation of Ras protein signal transduction | 36/2100 | 189/18723 | 1.01e-03 | 8.97e-03 | 36 |
GO:005105612 | Endometrium | EEC | regulation of small GTPase mediated signal transduction | 61/2168 | 302/18723 | 9.42e-06 | 2.08e-04 | 61 |
GO:000726513 | Endometrium | EEC | Ras protein signal transduction | 64/2168 | 337/18723 | 4.31e-05 | 7.10e-04 | 64 |
GO:004657813 | Endometrium | EEC | regulation of Ras protein signal transduction | 37/2168 | 189/18723 | 9.23e-04 | 8.32e-03 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND4A | SNV | Missense_Mutation | novel | c.5482N>A | p.Glu1828Lys | p.E1828K | Q7Z401 | protein_coding | deleterious(0.01) | benign(0.022) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DENND4A | SNV | Missense_Mutation | novel | c.4960C>G | p.Pro1654Ala | p.P1654A | Q7Z401 | protein_coding | deleterious(0) | benign(0.081) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
DENND4A | SNV | Missense_Mutation | novel | c.433N>G | p.Arg145Gly | p.R145G | Q7Z401 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
DENND4A | insertion | In_Frame_Ins | novel | c.4833_4834insAAA | p.Pro1611_Ala1612insLys | p.P1611_A1612insK | Q7Z401 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
DENND4A | insertion | Nonsense_Mutation | novel | c.3823_3824insAGTAGTGTATCTAAGTTAAATGAAG | p.Cys1275Ter | p.C1275* | Q7Z401 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
DENND4A | SNV | Missense_Mutation | rs370570206 | c.608N>T | p.Thr203Met | p.T203M | Q7Z401 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DENND4A | SNV | Missense_Mutation | c.3734G>A | p.Arg1245His | p.R1245H | Q7Z401 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DENND4A | SNV | Missense_Mutation | c.4451N>G | p.Tyr1484Cys | p.Y1484C | Q7Z401 | protein_coding | tolerated(0.24) | probably_damaging(0.995) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DENND4A | SNV | Missense_Mutation | rs369909860 | c.4628N>A | p.Arg1543Gln | p.R1543Q | Q7Z401 | protein_coding | tolerated(0.2) | possibly_damaging(0.47) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DENND4A | SNV | Missense_Mutation | c.1070N>A | p.Pro357His | p.P357H | Q7Z401 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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