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Gene: DDX50 |
Gene summary for DDX50 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DDX50 | Gene ID | 79009 |
Gene name | DExD-box helicase 50 | |
Gene Alias | GU2 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BQ39 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79009 | DDX50 | LZE4T | Human | Esophagus | ESCC | 4.58e-14 | 2.96e-01 | 0.0811 |
79009 | DDX50 | LZE5T | Human | Esophagus | ESCC | 1.92e-06 | 3.40e-01 | 0.0514 |
79009 | DDX50 | LZE7T | Human | Esophagus | ESCC | 2.92e-07 | 2.76e-01 | 0.0667 |
79009 | DDX50 | LZE8T | Human | Esophagus | ESCC | 2.43e-05 | 1.90e-01 | 0.067 |
79009 | DDX50 | LZE20T | Human | Esophagus | ESCC | 2.79e-05 | 1.86e-01 | 0.0662 |
79009 | DDX50 | LZE22D1 | Human | Esophagus | HGIN | 1.82e-09 | 2.34e-01 | 0.0595 |
79009 | DDX50 | LZE22T | Human | Esophagus | ESCC | 6.08e-04 | 3.91e-01 | 0.068 |
79009 | DDX50 | LZE24T | Human | Esophagus | ESCC | 1.89e-23 | 4.91e-01 | 0.0596 |
79009 | DDX50 | LZE6T | Human | Esophagus | ESCC | 8.69e-09 | 2.51e-01 | 0.0845 |
79009 | DDX50 | P1T-E | Human | Esophagus | ESCC | 5.87e-15 | 5.95e-01 | 0.0875 |
79009 | DDX50 | P2T-E | Human | Esophagus | ESCC | 1.81e-45 | 8.47e-01 | 0.1177 |
79009 | DDX50 | P4T-E | Human | Esophagus | ESCC | 2.03e-27 | 6.21e-01 | 0.1323 |
79009 | DDX50 | P5T-E | Human | Esophagus | ESCC | 5.23e-24 | 4.30e-01 | 0.1327 |
79009 | DDX50 | P8T-E | Human | Esophagus | ESCC | 5.57e-24 | 4.10e-01 | 0.0889 |
79009 | DDX50 | P9T-E | Human | Esophagus | ESCC | 2.61e-16 | 3.27e-01 | 0.1131 |
79009 | DDX50 | P10T-E | Human | Esophagus | ESCC | 1.20e-25 | 4.69e-01 | 0.116 |
79009 | DDX50 | P11T-E | Human | Esophagus | ESCC | 6.93e-20 | 3.53e-01 | 0.1426 |
79009 | DDX50 | P12T-E | Human | Esophagus | ESCC | 3.18e-35 | 6.52e-01 | 0.1122 |
79009 | DDX50 | P15T-E | Human | Esophagus | ESCC | 6.75e-27 | 4.60e-01 | 0.1149 |
79009 | DDX50 | P16T-E | Human | Esophagus | ESCC | 2.52e-29 | 5.58e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX50 | SNV | Missense_Mutation | c.770N>A | p.Arg257Gln | p.R257Q | Q9BQ39 | protein_coding | tolerated(0.06) | benign(0.379) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
DDX50 | deletion | Frame_Shift_Del | c.1011delN | p.Lys339AsnfsTer3 | p.K339Nfs*3 | Q9BQ39 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
DDX50 | deletion | Frame_Shift_Del | c.971delN | p.Ser326LeufsTer16 | p.S326Lfs*16 | Q9BQ39 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
DDX50 | insertion | In_Frame_Ins | novel | c.2013_2014insCATAAGCAA | p.Asn671_Thr672insHisLysGln | p.N671_T672insHKQ | Q9BQ39 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DDX50 | insertion | Frame_Shift_Ins | novel | c.2157_2158insTGTGTTTC | p.Arg720CysfsTer31 | p.R720Cfs*31 | Q9BQ39 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DDX50 | deletion | Frame_Shift_Del | c.1017delA | p.Lys339AsnfsTer3 | p.K339Nfs*3 | Q9BQ39 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
DDX50 | SNV | Missense_Mutation | novel | c.1084N>A | p.Val362Met | p.V362M | Q9BQ39 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | novel | c.2183N>T | p.Arg728Ile | p.R728I | Q9BQ39 | protein_coding | deleterious_low_confidence(0.04) | benign(0.146) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | novel | c.2197A>G | p.Lys733Glu | p.K733E | Q9BQ39 | protein_coding | deleterious_low_confidence(0) | benign(0.014) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | rs866420770 | c.696N>T | p.Lys232Asn | p.K232N | Q9BQ39 | protein_coding | deleterious(0.03) | benign(0.062) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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