![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DDX31 |
Gene summary for DDX31 |
![]() |
Gene information | Species | Human | Gene symbol | DDX31 | Gene ID | 64794 |
Gene name | DEAD-box helicase 31 | |
Gene Alias | PPP1R25 | |
Cytomap | 9q34.13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H8H2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64794 | DDX31 | CCI_2 | Human | Cervix | CC | 2.87e-14 | 7.55e-01 | 0.5249 |
64794 | DDX31 | CCI_3 | Human | Cervix | CC | 1.18e-10 | 5.26e-01 | 0.516 |
64794 | DDX31 | LZE4T | Human | Esophagus | ESCC | 1.12e-06 | 1.38e-01 | 0.0811 |
64794 | DDX31 | LZE24T | Human | Esophagus | ESCC | 3.47e-03 | 5.68e-02 | 0.0596 |
64794 | DDX31 | P2T-E | Human | Esophagus | ESCC | 1.51e-13 | 2.32e-01 | 0.1177 |
64794 | DDX31 | P4T-E | Human | Esophagus | ESCC | 7.40e-08 | 1.62e-01 | 0.1323 |
64794 | DDX31 | P5T-E | Human | Esophagus | ESCC | 2.65e-12 | 2.02e-01 | 0.1327 |
64794 | DDX31 | P8T-E | Human | Esophagus | ESCC | 4.62e-10 | 1.85e-01 | 0.0889 |
64794 | DDX31 | P9T-E | Human | Esophagus | ESCC | 1.62e-06 | 8.70e-02 | 0.1131 |
64794 | DDX31 | P10T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.31e-01 | 0.116 |
64794 | DDX31 | P11T-E | Human | Esophagus | ESCC | 2.12e-06 | 1.73e-01 | 0.1426 |
64794 | DDX31 | P12T-E | Human | Esophagus | ESCC | 4.35e-07 | 1.06e-01 | 0.1122 |
64794 | DDX31 | P15T-E | Human | Esophagus | ESCC | 2.94e-05 | 1.17e-01 | 0.1149 |
64794 | DDX31 | P16T-E | Human | Esophagus | ESCC | 1.05e-05 | 1.35e-01 | 0.1153 |
64794 | DDX31 | P17T-E | Human | Esophagus | ESCC | 8.70e-04 | 1.39e-01 | 0.1278 |
64794 | DDX31 | P20T-E | Human | Esophagus | ESCC | 2.65e-02 | 6.00e-02 | 0.1124 |
64794 | DDX31 | P21T-E | Human | Esophagus | ESCC | 1.12e-14 | 3.66e-01 | 0.1617 |
64794 | DDX31 | P22T-E | Human | Esophagus | ESCC | 3.60e-06 | 1.39e-01 | 0.1236 |
64794 | DDX31 | P23T-E | Human | Esophagus | ESCC | 7.27e-07 | 1.43e-01 | 0.108 |
64794 | DDX31 | P24T-E | Human | Esophagus | ESCC | 3.51e-15 | 2.23e-01 | 0.1287 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX31 | SNV | Missense_Mutation | c.1765N>A | p.Ala589Thr | p.A589T | Q9H8H2 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
DDX31 | SNV | Missense_Mutation | rs754917433 | c.1768C>T | p.Arg590Trp | p.R590W | Q9H8H2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX31 | SNV | Missense_Mutation | rs367667543 | c.523G>A | p.Ala175Thr | p.A175T | Q9H8H2 | protein_coding | tolerated(0.39) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX31 | SNV | Missense_Mutation | c.1997N>G | p.Asp666Gly | p.D666G | Q9H8H2 | protein_coding | tolerated(0.16) | possibly_damaging(0.864) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DDX31 | SNV | Missense_Mutation | c.1132N>A | p.His378Asn | p.H378N | Q9H8H2 | protein_coding | tolerated(0.31) | benign(0.048) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
DDX31 | deletion | Frame_Shift_Del | c.532delN | p.Met178CysfsTer42 | p.M178Cfs*42 | Q9H8H2 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |||
DDX31 | SNV | Missense_Mutation | novel | c.1093N>A | p.Gly365Arg | p.G365R | Q9H8H2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX31 | SNV | Missense_Mutation | novel | c.1904N>T | p.Ser635Leu | p.S635L | Q9H8H2 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DDX31 | SNV | Missense_Mutation | novel | c.1639N>T | p.Pro547Ser | p.P547S | Q9H8H2 | protein_coding | tolerated(0.21) | benign(0.056) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DDX31 | SNV | Missense_Mutation | rs376851094 | c.449N>A | p.Arg150Gln | p.R150Q | Q9H8H2 | protein_coding | tolerated(0.12) | probably_damaging(0.944) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |