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Gene: DDX17 |
Gene summary for DDX17 |
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Gene information | Species | Human | Gene symbol | DDX17 | Gene ID | 10521 |
Gene name | DEAD-box helicase 17 | |
Gene Alias | P72 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A1W2PQ51 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10521 | DDX17 | GSM4909285 | Human | Breast | IDC | 2.04e-04 | -2.33e-01 | 0.21 |
10521 | DDX17 | GSM4909293 | Human | Breast | IDC | 4.72e-05 | 1.97e-01 | 0.1581 |
10521 | DDX17 | GSM4909294 | Human | Breast | IDC | 5.48e-05 | -2.64e-01 | 0.2022 |
10521 | DDX17 | GSM4909296 | Human | Breast | IDC | 9.31e-14 | -3.51e-01 | 0.1524 |
10521 | DDX17 | GSM4909297 | Human | Breast | IDC | 5.48e-18 | -3.24e-01 | 0.1517 |
10521 | DDX17 | GSM4909308 | Human | Breast | IDC | 1.51e-03 | 1.42e-01 | 0.158 |
10521 | DDX17 | GSM4909311 | Human | Breast | IDC | 2.38e-38 | -4.19e-01 | 0.1534 |
10521 | DDX17 | GSM4909312 | Human | Breast | IDC | 2.38e-12 | -2.12e-01 | 0.1552 |
10521 | DDX17 | GSM4909313 | Human | Breast | IDC | 2.00e-04 | 2.14e-01 | 0.0391 |
10521 | DDX17 | GSM4909316 | Human | Breast | IDC | 3.66e-07 | -6.42e-01 | 0.21 |
10521 | DDX17 | GSM4909319 | Human | Breast | IDC | 1.34e-44 | -5.54e-01 | 0.1563 |
10521 | DDX17 | GSM4909320 | Human | Breast | IDC | 3.66e-11 | -6.33e-01 | 0.1575 |
10521 | DDX17 | GSM4909321 | Human | Breast | IDC | 8.37e-29 | -5.75e-01 | 0.1559 |
10521 | DDX17 | brca1 | Human | Breast | Precancer | 8.32e-07 | -4.12e-01 | -0.0338 |
10521 | DDX17 | brca10 | Human | Breast | Precancer | 3.26e-04 | -4.03e-01 | -0.0029 |
10521 | DDX17 | M1 | Human | Breast | IDC | 4.93e-10 | 4.86e-01 | 0.1577 |
10521 | DDX17 | M5 | Human | Breast | IDC | 1.36e-07 | 5.38e-01 | 0.1598 |
10521 | DDX17 | NCCBC14 | Human | Breast | DCIS | 3.54e-15 | -7.94e-02 | 0.2021 |
10521 | DDX17 | NCCBC2 | Human | Breast | DCIS | 9.73e-04 | 1.38e-01 | 0.1554 |
10521 | DDX17 | NCCBC3 | Human | Breast | DCIS | 2.22e-07 | 2.16e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00480249 | Breast | Precancer | regulation of mRNA splicing, via spliceosome | 22/1080 | 101/18723 | 5.29e-08 | 3.18e-06 | 22 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00506848 | Breast | Precancer | regulation of mRNA processing | 23/1080 | 137/18723 | 3.49e-06 | 1.13e-04 | 23 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:00003808 | Breast | Precancer | alternative mRNA splicing, via spliceosome | 15/1080 | 77/18723 | 2.86e-05 | 6.37e-04 | 15 |
GO:00003818 | Breast | Precancer | regulation of alternative mRNA splicing, via spliceosome | 13/1080 | 60/18723 | 2.98e-05 | 6.58e-04 | 13 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:00305217 | Breast | Precancer | androgen receptor signaling pathway | 10/1080 | 44/18723 | 1.61e-04 | 2.69e-03 | 10 |
GO:00305187 | Breast | Precancer | intracellular steroid hormone receptor signaling pathway | 16/1080 | 116/18723 | 1.01e-03 | 1.13e-02 | 16 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX17 | SNV | Missense_Mutation | c.1301N>C | p.Leu434Pro | p.L434P | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
DDX17 | SNV | Missense_Mutation | c.416N>T | p.Pro139Leu | p.P139L | protein_coding | deleterious(0.01) | benign(0.021) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DDX17 | deletion | Frame_Shift_Del | rs759023106 | c.362delN | p.Lys121SerfsTer4 | p.K121Sfs*4 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DDX17 | deletion | Frame_Shift_Del | rs759023106 | c.362delN | p.Lys121SerfsTer4 | p.K121Sfs*4 | protein_coding | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |||
DDX17 | deletion | Frame_Shift_Del | rs759023106 | c.362delN | p.Lys121SerfsTer4 | p.K121Sfs*4 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |||
DDX17 | SNV | Missense_Mutation | novel | c.1982C>T | p.Thr661Ile | p.T661I | protein_coding | tolerated_low_confidence(0.21) | benign(0.164) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DDX17 | SNV | Missense_Mutation | c.2174C>A | p.Pro725His | p.P725H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.993) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DDX17 | SNV | Missense_Mutation | novel | c.1377N>T | p.Trp459Cys | p.W459C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX17 | SNV | Missense_Mutation | novel | c.1111N>A | p.Leu371Ile | p.L371I | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX17 | SNV | Missense_Mutation | novel | c.848N>A | p.Pro283His | p.P283H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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