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Gene: CXCR6 |
Gene summary for CXCR6 |
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Gene information | Species | Human | Gene symbol | CXCR6 | Gene ID | 10663 |
Gene name | C-X-C motif chemokine receptor 6 | |
Gene Alias | BONZO | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A0N0N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10663 | CXCR6 | C21 | Human | Oral cavity | OSCC | 8.63e-03 | 2.41e-01 | 0.2678 |
10663 | CXCR6 | C38 | Human | Oral cavity | OSCC | 2.38e-04 | 9.69e-01 | 0.172 |
10663 | CXCR6 | LN22 | Human | Oral cavity | OSCC | 1.09e-03 | 6.57e-01 | 0.1733 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603220 | Oral cavity | OSCC | viral process | 274/7305 | 415/18723 | 2.42e-29 | 1.70e-26 | 274 |
GO:001905820 | Oral cavity | OSCC | viral life cycle | 208/7305 | 317/18723 | 4.59e-22 | 1.00e-19 | 208 |
GO:001907920 | Oral cavity | OSCC | viral genome replication | 95/7305 | 131/18723 | 6.35e-15 | 4.02e-13 | 95 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
GO:00603269 | Oral cavity | OSCC | cell chemotaxis | 146/7305 | 310/18723 | 2.13e-03 | 9.80e-03 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Breast | ADJ |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Breast | DCIS |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Breast | Healthy |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Breast | IDC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Breast | Precancer |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Cervix | ADJ |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Cervix | CC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Cervix | Precancer |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | CRC | MSI-H |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | CRC | SER |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Endometrium | ADJ |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Endometrium | AEH |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Endometrium | EEC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | GC | ADJ |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | GC | GC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | HNSCC | ADJ |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | HNSCC | OSCC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | HNSCC | Precancer |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Liver | HCC |
CXCL16 | CXCR6 | CXCL16_CXCR6 | CXCL | Liver | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CXCR6 | SNV | Missense_Mutation | novel | c.191N>T | p.Ser64Ile | p.S64I | O00574 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CXCR6 | SNV | Missense_Mutation | novel | c.667N>T | p.Gly223Cys | p.G223C | O00574 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CXCR6 | SNV | Missense_Mutation | novel | c.553N>A | p.Glu185Lys | p.E185K | O00574 | protein_coding | tolerated(0.52) | benign(0.284) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CXCR6 | SNV | Missense_Mutation | rs771852091 | c.53N>A | p.Ser18Asn | p.S18N | O00574 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CXCR6 | SNV | Missense_Mutation | novel | c.13N>A | p.Asp5Asn | p.D5N | O00574 | protein_coding | tolerated(0.07) | benign(0) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CXCR6 | SNV | Missense_Mutation | novel | c.978N>T | p.Lys326Asn | p.K326N | O00574 | protein_coding | deleterious(0.03) | possibly_damaging(0.522) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CXCR6 | SNV | Missense_Mutation | rs763564057 | c.641N>C | p.Ile214Thr | p.I214T | O00574 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BC-A10Y-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CXCR6 | SNV | Missense_Mutation | rs141955108 | c.887N>A | p.Arg296Gln | p.R296Q | O00574 | protein_coding | deleterious(0.02) | benign(0.116) | TCGA-69-7763-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CXCR6 | SNV | Missense_Mutation | rs771676006 | c.829G>A | p.Ala277Thr | p.A277T | O00574 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-EJ-5504-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
CXCR6 | SNV | Missense_Mutation | c.346N>C | p.Ser116Pro | p.S116P | O00574 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10663 | CXCR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | agonist | 178100558 | ||
10663 | CXCR6 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | agonist | 135651711 |
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