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Gene: CTSO |
Gene summary for CTSO |
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Gene information | Species | Human | Gene symbol | CTSO | Gene ID | 1519 |
Gene name | cathepsin O | |
Gene Alias | CTSO1 | |
Cytomap | 4q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P43234 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1519 | CTSO | S43 | Human | Liver | Cirrhotic | 1.08e-02 | -7.41e-02 | -0.0187 |
1519 | CTSO | HCC1_Meng | Human | Liver | HCC | 2.39e-21 | -6.49e-02 | 0.0246 |
1519 | CTSO | HCC2_Meng | Human | Liver | HCC | 7.41e-09 | -6.03e-02 | 0.0107 |
1519 | CTSO | cirrhotic2 | Human | Liver | Cirrhotic | 1.15e-03 | 1.31e-01 | 0.0201 |
1519 | CTSO | Pt13.b | Human | Liver | HCC | 3.90e-02 | 2.51e-02 | 0.0251 |
1519 | CTSO | S027 | Human | Liver | HCC | 9.84e-06 | 6.92e-01 | 0.2446 |
1519 | CTSO | S028 | Human | Liver | HCC | 3.29e-11 | 7.37e-01 | 0.2503 |
1519 | CTSO | S029 | Human | Liver | HCC | 1.62e-07 | 7.96e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0421011 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa042102 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa042103 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSO | SNV | Missense_Mutation | c.730N>G | p.Ile244Val | p.I244V | P43234 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-EO-A1Y5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
CTSO | SNV | Missense_Mutation | novel | c.266N>A | p.Pro89His | p.P89H | P43234 | protein_coding | tolerated(0.08) | benign(0.368) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTSO | SNV | Missense_Mutation | novel | c.899A>G | p.Tyr300Cys | p.Y300C | P43234 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSO | SNV | Missense_Mutation | novel | c.175N>T | p.Pro59Ser | p.P59S | P43234 | protein_coding | tolerated(0.93) | benign(0) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CTSO | SNV | Missense_Mutation | c.881N>A | p.Ser294Tyr | p.S294Y | P43234 | protein_coding | deleterious(0) | benign(0.439) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CTSO | SNV | Missense_Mutation | novel | c.814N>A | p.Leu272Ile | p.L272I | P43234 | protein_coding | tolerated(0.14) | benign(0.151) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CTSO | SNV | Missense_Mutation | novel | c.380N>G | p.Gln127Arg | p.Q127R | P43234 | protein_coding | tolerated(0.52) | benign(0.02) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTSO | SNV | Missense_Mutation | c.732A>G | p.Ile244Met | p.I244M | P43234 | protein_coding | deleterious(0.02) | possibly_damaging(0.657) | TCGA-55-7576-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | CR | |
CTSO | SNV | Missense_Mutation | c.881N>T | p.Ser294Phe | p.S294F | P43234 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CTSO | SNV | Missense_Mutation | novel | c.724N>T | p.Val242Leu | p.V242L | P43234 | protein_coding | deleterious(0.04) | benign(0.213) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1519 | CTSO | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL481611 | ODANACATIB |
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