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Gene: CSNK1G1 |
Gene summary for CSNK1G1 |
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Gene information | Species | Human | Gene symbol | CSNK1G1 | Gene ID | 53944 |
Gene name | casein kinase 1 gamma 1 | |
Gene Alias | CK1gamma1 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | U3KQB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53944 | CSNK1G1 | LZE4T | Human | Esophagus | ESCC | 9.45e-09 | 2.33e-01 | 0.0811 |
53944 | CSNK1G1 | LZE7T | Human | Esophagus | ESCC | 2.11e-02 | 3.26e-01 | 0.0667 |
53944 | CSNK1G1 | LZE20T | Human | Esophagus | ESCC | 4.67e-02 | 9.64e-02 | 0.0662 |
53944 | CSNK1G1 | LZE24T | Human | Esophagus | ESCC | 2.41e-08 | 1.49e-01 | 0.0596 |
53944 | CSNK1G1 | P2T-E | Human | Esophagus | ESCC | 8.86e-14 | 3.13e-01 | 0.1177 |
53944 | CSNK1G1 | P4T-E | Human | Esophagus | ESCC | 5.57e-09 | 2.59e-01 | 0.1323 |
53944 | CSNK1G1 | P5T-E | Human | Esophagus | ESCC | 4.20e-15 | 2.43e-01 | 0.1327 |
53944 | CSNK1G1 | P8T-E | Human | Esophagus | ESCC | 6.22e-13 | 3.25e-01 | 0.0889 |
53944 | CSNK1G1 | P9T-E | Human | Esophagus | ESCC | 4.46e-15 | 3.84e-01 | 0.1131 |
53944 | CSNK1G1 | P10T-E | Human | Esophagus | ESCC | 8.45e-17 | 3.31e-01 | 0.116 |
53944 | CSNK1G1 | P11T-E | Human | Esophagus | ESCC | 1.24e-11 | 3.19e-01 | 0.1426 |
53944 | CSNK1G1 | P12T-E | Human | Esophagus | ESCC | 3.72e-17 | 4.02e-01 | 0.1122 |
53944 | CSNK1G1 | P15T-E | Human | Esophagus | ESCC | 4.75e-22 | 4.65e-01 | 0.1149 |
53944 | CSNK1G1 | P16T-E | Human | Esophagus | ESCC | 7.99e-15 | 2.95e-01 | 0.1153 |
53944 | CSNK1G1 | P20T-E | Human | Esophagus | ESCC | 6.95e-12 | 3.17e-01 | 0.1124 |
53944 | CSNK1G1 | P21T-E | Human | Esophagus | ESCC | 3.33e-10 | 2.15e-01 | 0.1617 |
53944 | CSNK1G1 | P22T-E | Human | Esophagus | ESCC | 3.05e-18 | 2.08e-01 | 0.1236 |
53944 | CSNK1G1 | P23T-E | Human | Esophagus | ESCC | 7.97e-20 | 4.86e-01 | 0.108 |
53944 | CSNK1G1 | P24T-E | Human | Esophagus | ESCC | 1.56e-08 | 2.04e-01 | 0.1287 |
53944 | CSNK1G1 | P26T-E | Human | Esophagus | ESCC | 1.75e-26 | 4.94e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:009026316 | Esophagus | ESCC | positive regulation of canonical Wnt signaling pathway | 69/8552 | 106/18723 | 4.22e-05 | 3.39e-04 | 69 |
GO:003017716 | Esophagus | ESCC | positive regulation of Wnt signaling pathway | 87/8552 | 140/18723 | 6.18e-05 | 4.73e-04 | 87 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
GO:009026321 | Liver | HCC | positive regulation of canonical Wnt signaling pathway | 62/7958 | 106/18723 | 6.44e-04 | 3.99e-03 | 62 |
GO:00160556 | Lung | IAC | Wnt signaling pathway | 95/2061 | 444/18723 | 1.13e-10 | 2.80e-08 | 95 |
GO:01987386 | Lung | IAC | cell-cell signaling by wnt | 95/2061 | 446/18723 | 1.46e-10 | 3.48e-08 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04340 | Lung | AIS | Hedgehog signaling pathway | 14/961 | 56/8465 | 3.21e-03 | 1.82e-02 | 1.17e-02 | 14 |
hsa043401 | Lung | AIS | Hedgehog signaling pathway | 14/961 | 56/8465 | 3.21e-03 | 1.82e-02 | 1.17e-02 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK1G1 | SNV | Missense_Mutation | c.488N>C | p.Arg163Pro | p.R163P | Q9HCP0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CSNK1G1 | SNV | Missense_Mutation | novel | c.821N>T | p.Pro274Leu | p.P274L | Q9HCP0 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSNK1G1 | SNV | Missense_Mutation | novel | c.667N>T | p.His223Tyr | p.H223Y | Q9HCP0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CSNK1G1 | SNV | Missense_Mutation | novel | c.353N>C | p.Leu118Pro | p.L118P | Q9HCP0 | protein_coding | deleterious(0.03) | possibly_damaging(0.653) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CSNK1G1 | insertion | Frame_Shift_Ins | novel | c.489_490insACCCAGTTTTC | p.Asp164ThrfsTer12 | p.D164Tfs*12 | Q9HCP0 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CSNK1G1 | SNV | Missense_Mutation | c.310N>A | p.Val104Met | p.V104M | Q9HCP0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-DD-A4NF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CSNK1G1 | SNV | Missense_Mutation | c.1048N>G | p.Thr350Ala | p.T350A | Q9HCP0 | protein_coding | tolerated(0.47) | benign(0.009) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
CSNK1G1 | SNV | Missense_Mutation | c.470C>T | p.Ser157Leu | p.S157L | Q9HCP0 | protein_coding | deleterious(0.04) | possibly_damaging(0.484) | TCGA-95-7948-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CSNK1G1 | SNV | Missense_Mutation | c.848C>T | p.Pro283Leu | p.P283L | Q9HCP0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CSNK1G1 | SNV | Missense_Mutation | c.1052N>C | p.Arg351Pro | p.R351P | Q9HCP0 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-66-2792-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565843 | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | PF-562271 | PF-00562271 | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | CENISERTIB | CENISERTIB | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | ALSTERPAULLONE | ALSTERPAULLONE | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | ILORASERTIB | ILORASERTIB | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | CHIR-99021 | CHIR-99021 | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 363894217 | VORUCICLIB | |
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | CYC-116 | CYC-116 | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | PHA-767491 | CHEMBL225519 | ||
53944 | CSNK1G1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | (RS)-ROSCOVITINE | (RS)-ROSCOVITINE |
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