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Gene: CRYM |
Gene summary for CRYM |
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Gene information | Species | Human | Gene symbol | CRYM | Gene ID | 1428 |
Gene name | crystallin mu | |
Gene Alias | DFNA40 | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q14894 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1428 | CRYM | HCC1_Meng | Human | Liver | HCC | 1.89e-25 | 5.11e-02 | 0.0246 |
1428 | CRYM | HCC1 | Human | Liver | HCC | 4.30e-02 | 2.21e+00 | 0.5336 |
1428 | CRYM | S014 | Human | Liver | HCC | 1.19e-07 | 3.77e-01 | 0.2254 |
1428 | CRYM | S015 | Human | Liver | HCC | 1.13e-10 | 5.06e-01 | 0.2375 |
1428 | CRYM | S016 | Human | Liver | HCC | 1.11e-09 | 3.77e-01 | 0.2243 |
1428 | CRYM | S028 | Human | Liver | HCC | 1.83e-06 | 2.45e-01 | 0.2503 |
1428 | CRYM | S029 | Human | Liver | HCC | 1.71e-04 | 1.99e-01 | 0.2581 |
1428 | CRYM | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 4.98e-10 | 5.03e-01 | -0.2126 |
1428 | CRYM | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 1.99e-07 | 3.27e-01 | -0.1833 |
1428 | CRYM | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 7.98e-13 | 1.00e+00 | -0.23 |
1428 | CRYM | Dong_P3 | Human | Prostate | Tumor | 9.42e-11 | 2.10e-01 | 0.0278 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
GO:001605421 | Liver | HCC | organic acid catabolic process | 152/7958 | 240/18723 | 5.11e-11 | 1.92e-09 | 152 |
GO:00463952 | Liver | HCC | carboxylic acid catabolic process | 149/7958 | 236/18723 | 1.11e-10 | 3.87e-09 | 149 |
GO:19016052 | Liver | HCC | alpha-amino acid metabolic process | 124/7958 | 195/18723 | 2.07e-09 | 5.79e-08 | 124 |
GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:00090632 | Liver | HCC | cellular amino acid catabolic process | 70/7958 | 110/18723 | 6.12e-06 | 7.52e-05 | 70 |
GO:00090662 | Liver | HCC | aspartate family amino acid metabolic process | 34/7958 | 49/18723 | 1.28e-04 | 1.06e-03 | 34 |
GO:19016062 | Liver | HCC | alpha-amino acid catabolic process | 53/7958 | 87/18723 | 4.01e-04 | 2.71e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYM | SNV | Missense_Mutation | novel | c.556N>G | p.Arg186Gly | p.R186G | Q14894 | protein_coding | tolerated(0.07) | benign(0.079) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CRYM | SNV | Missense_Mutation | c.430G>T | p.Ala144Ser | p.A144S | Q14894 | protein_coding | tolerated(0.76) | benign(0.07) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRYM | SNV | Missense_Mutation | rs553362900 | c.323N>T | p.Ala108Val | p.A108V | Q14894 | protein_coding | tolerated(0.08) | benign(0.185) | TCGA-77-A5G7-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRYM | SNV | Missense_Mutation | rs748606222 | c.698N>C | p.Trp233Ser | p.W233S | Q14894 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-85-8287-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CRYM | SNV | Missense_Mutation | novel | c.631N>C | p.Ile211Leu | p.I211L | Q14894 | protein_coding | deleterious(0.02) | benign(0.121) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRYM | SNV | Missense_Mutation | c.768N>T | p.Lys256Asn | p.K256N | Q14894 | protein_coding | tolerated(0.24) | benign(0.214) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRYM | SNV | Missense_Mutation | c.289N>A | p.Leu97Ile | p.L97I | Q14894 | protein_coding | tolerated(0.24) | benign(0.202) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CRYM | SNV | Missense_Mutation | novel | c.710N>G | p.Asp237Gly | p.D237G | Q14894 | protein_coding | tolerated(0.05) | possibly_damaging(0.873) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CRYM | SNV | Missense_Mutation | c.815N>A | p.Leu272Gln | p.L272Q | Q14894 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-DJ-A3VF-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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