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Gene: CPNE7 |
Gene summary for CPNE7 |
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Gene information | Species | Human | Gene symbol | CPNE7 | Gene ID | 27132 |
Gene name | copine 7 | |
Gene Alias | CPNE7 | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9UBL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27132 | CPNE7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 2.21e-01 | 0.0216 |
27132 | CPNE7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.63e-02 | 1.16e-01 | -0.059 |
27132 | CPNE7 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.51e-05 | 1.58e-01 | 0.096 |
27132 | CPNE7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.67e-03 | 1.33e-01 | 0.0338 |
27132 | CPNE7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.56e-07 | 1.76e-01 | 0.0674 |
27132 | CPNE7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.24e-29 | 5.36e-01 | 0.294 |
27132 | CPNE7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.91e-05 | 2.12e-01 | 0.281 |
27132 | CPNE7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.67e-33 | 8.17e-01 | 0.3859 |
27132 | CPNE7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.16e-14 | 4.46e-01 | 0.2585 |
27132 | CPNE7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.56e-26 | 4.48e-01 | 0.3005 |
27132 | CPNE7 | F007 | Human | Colorectum | FAP | 9.14e-05 | 2.88e-01 | 0.1176 |
27132 | CPNE7 | A001-C-207 | Human | Colorectum | FAP | 2.75e-02 | 1.83e-01 | 0.1278 |
27132 | CPNE7 | A015-C-203 | Human | Colorectum | FAP | 3.85e-03 | 2.15e-01 | -0.1294 |
27132 | CPNE7 | A002-C-201 | Human | Colorectum | FAP | 3.61e-02 | 2.03e-01 | 0.0324 |
27132 | CPNE7 | A002-C-203 | Human | Colorectum | FAP | 4.07e-04 | 2.23e-01 | 0.2786 |
27132 | CPNE7 | A002-C-021 | Human | Colorectum | FAP | 1.82e-03 | 1.24e-01 | 0.1171 |
27132 | CPNE7 | A015-C-006 | Human | Colorectum | FAP | 3.48e-02 | 2.62e-01 | -0.0994 |
27132 | CPNE7 | A001-C-007 | Human | Colorectum | CRC | 1.09e-06 | 3.76e-01 | 0.1899 |
27132 | CPNE7 | F034 | Human | Colorectum | FAP | 8.62e-04 | 2.32e-01 | -0.0665 |
27132 | CPNE7 | F072B | Human | Colorectum | FAP | 3.61e-02 | 1.82e-01 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0071248 | Colorectum | AD | cellular response to metal ion | 61/3918 | 197/18723 | 5.74e-04 | 6.09e-03 | 61 |
GO:0071241 | Colorectum | AD | cellular response to inorganic substance | 68/3918 | 226/18723 | 6.98e-04 | 7.10e-03 | 68 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00712412 | Colorectum | MSS | cellular response to inorganic substance | 57/3467 | 226/18723 | 7.27e-03 | 4.64e-02 | 57 |
GO:0051592 | Colorectum | FAP | response to calcium ion | 33/2622 | 149/18723 | 4.52e-03 | 3.08e-02 | 33 |
GO:00100384 | Colorectum | FAP | response to metal ion | 70/2622 | 373/18723 | 5.95e-03 | 3.75e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPNE7 | SNV | Missense_Mutation | novel | c.1838G>T | p.Arg613Ile | p.R613I | Q9UBL6 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE7 | SNV | Missense_Mutation | rs753486988 | c.1678N>A | p.Gly560Ser | p.G560S | Q9UBL6 | protein_coding | tolerated(0.05) | possibly_damaging(0.838) | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPNE7 | SNV | Missense_Mutation | novel | c.328N>A | p.Leu110Met | p.L110M | Q9UBL6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE7 | SNV | Missense_Mutation | c.1714N>T | p.Pro572Ser | p.P572S | Q9UBL6 | protein_coding | tolerated(0.05) | benign(0.131) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CPNE7 | SNV | Missense_Mutation | rs371577272 | c.1570G>A | p.Asp524Asn | p.D524N | Q9UBL6 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE7 | SNV | Missense_Mutation | novel | c.439N>G | p.Phe147Val | p.F147V | Q9UBL6 | protein_coding | tolerated(0.55) | benign(0) | TCGA-D1-A2G6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CPNE7 | SNV | Missense_Mutation | c.1403N>A | p.Gly468Asp | p.G468D | Q9UBL6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
CPNE7 | SNV | Missense_Mutation | c.269G>A | p.Arg90His | p.R90H | Q9UBL6 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
CPNE7 | SNV | Missense_Mutation | rs762215334 | c.1660N>A | p.Asp554Asn | p.D554N | Q9UBL6 | protein_coding | tolerated(0.3) | benign(0.259) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPNE7 | SNV | Missense_Mutation | novel | c.1799C>T | p.Ala600Val | p.A600V | Q9UBL6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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