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Gene: CPD |
Gene summary for CPD |
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Gene information | Species | Human | Gene symbol | CPD | Gene ID | 1362 |
Gene name | carboxypeptidase D | |
Gene Alias | GP180 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | O75976 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1362 | CPD | LZE2T | Human | Esophagus | ESCC | 5.59e-08 | 5.23e-01 | 0.082 |
1362 | CPD | LZE4T | Human | Esophagus | ESCC | 1.60e-10 | 2.34e-01 | 0.0811 |
1362 | CPD | LZE5T | Human | Esophagus | ESCC | 1.99e-06 | 2.05e+00 | 0.0514 |
1362 | CPD | LZE7T | Human | Esophagus | ESCC | 1.97e-04 | 2.11e-01 | 0.0667 |
1362 | CPD | LZE20T | Human | Esophagus | ESCC | 2.50e-02 | 1.44e-02 | 0.0662 |
1362 | CPD | LZE22T | Human | Esophagus | ESCC | 1.43e-03 | 1.36e-01 | 0.068 |
1362 | CPD | LZE24T | Human | Esophagus | ESCC | 1.85e-17 | 5.22e-01 | 0.0596 |
1362 | CPD | LZE21T | Human | Esophagus | ESCC | 1.43e-05 | 3.37e-01 | 0.0655 |
1362 | CPD | LZE6T | Human | Esophagus | ESCC | 2.67e-04 | 4.78e-02 | 0.0845 |
1362 | CPD | P2T-E | Human | Esophagus | ESCC | 1.33e-20 | 4.56e-01 | 0.1177 |
1362 | CPD | P4T-E | Human | Esophagus | ESCC | 5.68e-09 | 2.76e-01 | 0.1323 |
1362 | CPD | P5T-E | Human | Esophagus | ESCC | 6.48e-04 | 9.52e-02 | 0.1327 |
1362 | CPD | P8T-E | Human | Esophagus | ESCC | 3.57e-36 | 9.35e-01 | 0.0889 |
1362 | CPD | P9T-E | Human | Esophagus | ESCC | 2.19e-05 | 1.78e-01 | 0.1131 |
1362 | CPD | P10T-E | Human | Esophagus | ESCC | 5.11e-12 | 1.73e-02 | 0.116 |
1362 | CPD | P11T-E | Human | Esophagus | ESCC | 1.29e-02 | 4.13e-01 | 0.1426 |
1362 | CPD | P12T-E | Human | Esophagus | ESCC | 5.80e-24 | 3.26e-01 | 0.1122 |
1362 | CPD | P15T-E | Human | Esophagus | ESCC | 1.36e-19 | 5.10e-01 | 0.1149 |
1362 | CPD | P16T-E | Human | Esophagus | ESCC | 1.16e-14 | 3.05e-01 | 0.1153 |
1362 | CPD | P17T-E | Human | Esophagus | ESCC | 4.09e-07 | 2.15e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00075192 | Cervix | CC | skeletal muscle tissue development | 30/2311 | 155/18723 | 7.97e-03 | 4.18e-02 | 30 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00442422 | Colorectum | FAP | cellular lipid catabolic process | 49/2622 | 214/18723 | 2.87e-04 | 3.77e-03 | 49 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00464861 | Colorectum | CRC | glycerolipid metabolic process | 64/2078 | 392/18723 | 1.01e-03 | 1.19e-02 | 64 |
GO:00160424 | Colorectum | CRC | lipid catabolic process | 53/2078 | 320/18723 | 1.89e-03 | 1.93e-02 | 53 |
GO:0060537 | Colorectum | CRC | muscle tissue development | 63/2078 | 403/18723 | 3.17e-03 | 2.78e-02 | 63 |
GO:00442423 | Colorectum | CRC | cellular lipid catabolic process | 37/2078 | 214/18723 | 4.16e-03 | 3.40e-02 | 37 |
GO:0014706 | Colorectum | CRC | striated muscle tissue development | 59/2078 | 384/18723 | 6.11e-03 | 4.47e-02 | 59 |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:00605382 | Endometrium | AEH | skeletal muscle organ development | 30/2100 | 166/18723 | 5.64e-03 | 3.46e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPD | SNV | Missense_Mutation | c.3736N>T | p.Gly1246Cys | p.G1246C | O75976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CPD | SNV | Missense_Mutation | c.2348G>T | p.Arg783Ile | p.R783I | O75976 | protein_coding | deleterious(0.02) | possibly_damaging(0.611) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPD | SNV | Missense_Mutation | c.2626G>T | p.Asp876Tyr | p.D876Y | O75976 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPD | SNV | Missense_Mutation | c.2669N>C | p.Ser890Thr | p.S890T | O75976 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CPD | SNV | Missense_Mutation | c.1006G>A | p.Asp336Asn | p.D336N | O75976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPD | SNV | Missense_Mutation | novel | c.3531N>C | p.Glu1177Asp | p.E1177D | O75976 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPD | SNV | Missense_Mutation | c.1912N>A | p.Pro638Thr | p.P638T | O75976 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AZ-4684-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | folfox | PD | |
CPD | SNV | Missense_Mutation | novel | c.1514N>C | p.His505Pro | p.H505P | O75976 | protein_coding | deleterious(0.05) | benign(0.31) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CPD | SNV | Missense_Mutation | rs746161892 | c.1904N>A | p.Arg635Gln | p.R635Q | O75976 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CPD | SNV | Missense_Mutation | c.195G>T | p.Glu65Asp | p.E65D | O75976 | protein_coding | tolerated(0.59) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1362 | CPD | ENZYME, DRUGGABLE GENOME, PROTEASE | ANTISERUM | 9490632 |
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