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Gene: CORO1B |
Gene summary for CORO1B |
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Gene information | Species | Human | Gene symbol | CORO1B | Gene ID | 57175 |
Gene name | coronin 1B | |
Gene Alias | CORONIN-2 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57175 | CORO1B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.20e-04 | 1.56e-01 | 0.0155 |
57175 | CORO1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.81e-27 | 7.47e-01 | -0.1808 |
57175 | CORO1B | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.14e-03 | 3.47e-01 | 0.0216 |
57175 | CORO1B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.82e-08 | 3.50e-01 | -0.0811 |
57175 | CORO1B | HTA11_78_2000001011 | Human | Colorectum | AD | 5.30e-17 | 4.25e-01 | -0.1088 |
57175 | CORO1B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-25 | 5.73e-01 | -0.1954 |
57175 | CORO1B | HTA11_411_2000001011 | Human | Colorectum | SER | 9.97e-09 | 9.35e-01 | -0.2602 |
57175 | CORO1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.33e-08 | 6.64e-01 | -0.2196 |
57175 | CORO1B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.68e-08 | 3.28e-01 | -0.1207 |
57175 | CORO1B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.29e-04 | 3.17e-01 | -0.1526 |
57175 | CORO1B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.48e-22 | 4.60e-01 | -0.1464 |
57175 | CORO1B | HTA11_866_2000001011 | Human | Colorectum | AD | 3.84e-03 | 1.79e-01 | -0.1001 |
57175 | CORO1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.53e-16 | 4.57e-01 | -0.059 |
57175 | CORO1B | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.44e-10 | 5.26e-01 | -0.2061 |
57175 | CORO1B | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.08e-03 | 2.94e-01 | -0.1462 |
57175 | CORO1B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.50e-06 | 3.60e-01 | -0.0842 |
57175 | CORO1B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-03 | 1.75e-01 | 0.096 |
57175 | CORO1B | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.90e-03 | 4.85e-01 | 0.0451 |
57175 | CORO1B | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.22e-06 | 3.97e-01 | 0.0528 |
57175 | CORO1B | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.27e-08 | 3.95e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CORO1B | SNV | Missense_Mutation | novel | c.229A>T | p.Thr77Ser | p.T77S | Q9BR76 | protein_coding | tolerated(0.4) | possibly_damaging(0.491) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CORO1B | SNV | Missense_Mutation | c.766N>C | p.Glu256Gln | p.E256Q | Q9BR76 | protein_coding | tolerated(0.26) | benign(0.017) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CORO1B | SNV | Missense_Mutation | novel | c.184G>T | p.Val62Leu | p.V62L | Q9BR76 | protein_coding | deleterious(0.01) | possibly_damaging(0.847) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CORO1B | SNV | Missense_Mutation | novel | c.506N>G | p.Tyr169Cys | p.Y169C | Q9BR76 | protein_coding | tolerated(0.09) | benign(0.02) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | novel | c.10N>T | p.Arg4Cys | p.R4C | Q9BR76 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
CORO1B | SNV | Missense_Mutation | rs149833628 | c.1160C>T | p.Pro387Leu | p.P387L | Q9BR76 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CORO1B | SNV | Missense_Mutation | c.706N>G | p.Thr236Ala | p.T236A | Q9BR76 | protein_coding | deleterious(0) | benign(0.244) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CORO1B | SNV | Missense_Mutation | c.623G>A | p.Gly208Asp | p.G208D | Q9BR76 | protein_coding | deleterious(0.01) | possibly_damaging(0.69) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CORO1B | SNV | Missense_Mutation | rs761036671 | c.985G>A | p.Val329Ile | p.V329I | Q9BR76 | protein_coding | tolerated(0.08) | possibly_damaging(0.732) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs747383937 | c.665G>A | p.Arg222Gln | p.R222Q | Q9BR76 | protein_coding | deleterious(0) | benign(0.224) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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