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Gene: COL9A2 |
Gene summary for COL9A2 |
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Gene information | Species | Human | Gene symbol | COL9A2 | Gene ID | 1298 |
Gene name | collagen type IX alpha 2 chain | |
Gene Alias | DJ39G22.4 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q14055 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1298 | COL9A2 | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 9.86e-02 | 0.067 |
1298 | COL9A2 | LZE22D1 | Human | Esophagus | HGIN | 3.26e-02 | 1.32e-01 | 0.0595 |
1298 | COL9A2 | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 2.41e-01 | 0.068 |
1298 | COL9A2 | LZE24T | Human | Esophagus | ESCC | 3.17e-06 | 1.67e-01 | 0.0596 |
1298 | COL9A2 | P1T-E | Human | Esophagus | ESCC | 7.43e-09 | 3.54e-01 | 0.0875 |
1298 | COL9A2 | P2T-E | Human | Esophagus | ESCC | 1.21e-58 | 1.03e+00 | 0.1177 |
1298 | COL9A2 | P8T-E | Human | Esophagus | ESCC | 2.87e-11 | 1.81e-01 | 0.0889 |
1298 | COL9A2 | P10T-E | Human | Esophagus | ESCC | 1.21e-34 | 5.65e-01 | 0.116 |
1298 | COL9A2 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 2.11e-01 | 0.1426 |
1298 | COL9A2 | P12T-E | Human | Esophagus | ESCC | 2.60e-26 | 5.14e-01 | 0.1122 |
1298 | COL9A2 | P15T-E | Human | Esophagus | ESCC | 8.45e-04 | 1.24e-01 | 0.1149 |
1298 | COL9A2 | P16T-E | Human | Esophagus | ESCC | 1.37e-54 | 9.22e-01 | 0.1153 |
1298 | COL9A2 | P17T-E | Human | Esophagus | ESCC | 2.68e-03 | 2.27e-01 | 0.1278 |
1298 | COL9A2 | P20T-E | Human | Esophagus | ESCC | 3.97e-02 | 9.69e-02 | 0.1124 |
1298 | COL9A2 | P21T-E | Human | Esophagus | ESCC | 2.16e-02 | 5.09e-02 | 0.1617 |
1298 | COL9A2 | P22T-E | Human | Esophagus | ESCC | 1.02e-10 | 1.34e-01 | 0.1236 |
1298 | COL9A2 | P23T-E | Human | Esophagus | ESCC | 7.44e-14 | 3.19e-01 | 0.108 |
1298 | COL9A2 | P24T-E | Human | Esophagus | ESCC | 6.73e-07 | 1.02e-01 | 0.1287 |
1298 | COL9A2 | P26T-E | Human | Esophagus | ESCC | 3.27e-15 | 2.69e-01 | 0.1276 |
1298 | COL9A2 | P27T-E | Human | Esophagus | ESCC | 2.99e-22 | 6.96e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa04510111 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
COL9A2 | ITGA1_ITGB1 | COL9A2_ITGA1_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA2_ITGB1 | COL9A2_ITGA2_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA3_ITGB1 | COL9A2_ITGA3_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA9_ITGB1 | COL9A2_ITGA9_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA11_ITGB1 | COL9A2_ITGA11_ITGB1 | COLLAGEN | Cervix | CC |
COL9A2 | ITGAV_ITGB8 | COL9A2_ITGAV_ITGB8 | COLLAGEN | Cervix | CC |
COL9A2 | CD44 | COL9A2_CD44 | COLLAGEN | Cervix | CC |
COL9A2 | SDC1 | COL9A2_SDC1 | COLLAGEN | Cervix | CC |
COL9A2 | SDC4 | COL9A2_SDC4 | COLLAGEN | Cervix | CC |
COL9A2 | ITGA1_ITGB1 | COL9A2_ITGA1_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA3_ITGB1 | COL9A2_ITGA3_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA9_ITGB1 | COL9A2_ITGA9_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA10_ITGB1 | COL9A2_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA11_ITGB1 | COL9A2_ITGA11_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | CD44 | COL9A2_CD44 | COLLAGEN | THCA | ADJ |
COL9A2 | SDC4 | COL9A2_SDC4 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA1_ITGB1 | COL9A2_ITGA1_ITGB1 | COLLAGEN | THCA | Cancer |
COL9A2 | ITGA2_ITGB1 | COL9A2_ITGA2_ITGB1 | COLLAGEN | THCA | Cancer |
COL9A2 | ITGA3_ITGB1 | COL9A2_ITGA3_ITGB1 | COLLAGEN | THCA | Cancer |
COL9A2 | ITGA9_ITGB1 | COL9A2_ITGA9_ITGB1 | COLLAGEN | THCA | Cancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COL9A2 | SNV | Missense_Mutation | novel | c.919N>T | p.Gly307Cys | p.G307C | Q14055 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COL9A2 | SNV | Missense_Mutation | novel | c.176N>T | p.Ala59Val | p.A59V | Q14055 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COL9A2 | SNV | Missense_Mutation | novel | c.274N>T | p.Pro92Ser | p.P92S | Q14055 | protein_coding | deleterious(0.04) | possibly_damaging(0.85) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COL9A2 | SNV | Missense_Mutation | c.79N>T | p.Gly27Cys | p.G27C | Q14055 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COL9A2 | SNV | Missense_Mutation | c.1837N>T | p.His613Tyr | p.H613Y | Q14055 | protein_coding | tolerated(0.56) | probably_damaging(0.992) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COL9A2 | SNV | Missense_Mutation | novel | c.691N>G | p.Gln231Glu | p.Q231E | Q14055 | protein_coding | tolerated(0.14) | benign(0.086) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
COL9A2 | SNV | Missense_Mutation | novel | c.301N>G | p.Lys101Glu | p.K101E | Q14055 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
COL9A2 | SNV | Missense_Mutation | c.1586N>T | p.Ala529Val | p.A529V | Q14055 | protein_coding | tolerated(0.73) | benign(0.018) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COL9A2 | SNV | Missense_Mutation | novel | c.1759N>A | p.Ala587Thr | p.A587T | Q14055 | protein_coding | deleterious(0.04) | probably_damaging(0.962) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COL9A2 | SNV | Missense_Mutation | c.856N>T | p.Gly286Cys | p.G286C | Q14055 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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