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Gene: COL21A1 |
Gene summary for COL21A1 |
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Gene information | Species | Human | Gene symbol | COL21A1 | Gene ID | 81578 |
Gene name | collagen type XXI alpha 1 chain | |
Gene Alias | COLA1L | |
Cytomap | 6p12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A158RFW1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81578 | COL21A1 | HCC1_Meng | Human | Liver | HCC | 1.18e-05 | 2.13e-02 | 0.0246 |
81578 | COL21A1 | S014 | Human | Liver | HCC | 2.66e-21 | 8.21e-01 | 0.2254 |
81578 | COL21A1 | S015 | Human | Liver | HCC | 8.47e-13 | 8.57e-01 | 0.2375 |
81578 | COL21A1 | S016 | Human | Liver | HCC | 3.30e-41 | 1.45e+00 | 0.2243 |
81578 | COL21A1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.71e-02 | 4.56e-01 | 0.343 |
81578 | COL21A1 | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.25e-04 | 1.08e+00 | 0.1151 |
81578 | COL21A1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.50e-08 | 3.55e-01 | -0.0166 |
81578 | COL21A1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.48e-12 | 4.21e-01 | -0.0132 |
81578 | COL21A1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.28e-10 | 3.87e-01 | -0.013 |
81578 | COL21A1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.47e-07 | 3.46e-01 | -0.0121 |
81578 | COL21A1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.94e-06 | 5.71e-01 | -0.0961 |
81578 | COL21A1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.28e-04 | 4.38e-01 | -0.0876 |
81578 | COL21A1 | ATC13 | Human | Thyroid | ATC | 1.76e-41 | 9.83e-01 | 0.34 |
81578 | COL21A1 | ATC5 | Human | Thyroid | ATC | 5.12e-38 | 1.05e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COL21A1 | SNV | Missense_Mutation | novel | c.1811C>A | p.Pro604His | p.P604H | Q96P44 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
COL21A1 | SNV | Missense_Mutation | c.2293N>A | p.Pro765Thr | p.P765T | Q96P44 | protein_coding | tolerated(0.62) | possibly_damaging(0.519) | TCGA-G4-6311-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
COL21A1 | SNV | Missense_Mutation | c.1110N>G | p.Ile370Met | p.I370M | Q96P44 | protein_coding | deleterious(0.03) | probably_damaging(0.928) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
COL21A1 | SNV | Missense_Mutation | c.547N>A | p.Ala183Thr | p.A183T | Q96P44 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COL21A1 | SNV | Missense_Mutation | c.398N>A | p.Arg133Gln | p.R133Q | Q96P44 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COL21A1 | SNV | Missense_Mutation | novel | c.1543N>T | p.Gly515Cys | p.G515C | Q96P44 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
COL21A1 | SNV | Missense_Mutation | c.2221N>A | p.Glu741Lys | p.E741K | Q96P44 | protein_coding | tolerated(0.29) | benign(0.251) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COL21A1 | SNV | Missense_Mutation | c.876N>T | p.Lys292Asn | p.K292N | Q96P44 | protein_coding | tolerated(0.13) | possibly_damaging(0.738) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
COL21A1 | SNV | Missense_Mutation | novel | c.2605A>C | p.Lys869Gln | p.K869Q | Q96P44 | protein_coding | tolerated(0.05) | possibly_damaging(0.824) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COL21A1 | insertion | Frame_Shift_Ins | novel | c.2369_2370insTGTTATCTGTTTTCTTCTTCACCTCACTTATATCCTCT | p.Glu790AspfsTer24 | p.E790Dfs*24 | Q96P44 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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