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Gene: CLN8 |
Gene summary for CLN8 |
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Gene information | Species | Human | Gene symbol | CLN8 | Gene ID | 2055 |
Gene name | CLN8 transmembrane ER and ERGIC protein | |
Gene Alias | C8orf61 | |
Cytomap | 8p23.3 | |
Gene Type | protein-coding | GO ID | GO:0001306 | UniProtAcc | A0A024QZ57 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2055 | CLN8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.55e-04 | 1.18e-01 | 0.0155 |
2055 | CLN8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.70e-09 | 2.66e-01 | -0.1808 |
2055 | CLN8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.85e-11 | 3.61e-01 | -0.0811 |
2055 | CLN8 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.54e-12 | 3.79e-01 | -0.1088 |
2055 | CLN8 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.45e-16 | 3.56e-01 | -0.1954 |
2055 | CLN8 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 4.38e-01 | -0.2602 |
2055 | CLN8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 2.76e-01 | -0.2196 |
2055 | CLN8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.86e-11 | 3.50e-01 | -0.1207 |
2055 | CLN8 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 2.84e-01 | -0.1526 |
2055 | CLN8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.58e-13 | 2.69e-01 | -0.1464 |
2055 | CLN8 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.94e-11 | 2.48e-01 | -0.1001 |
2055 | CLN8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.92e-14 | 3.71e-01 | -0.059 |
2055 | CLN8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.63e-01 | -0.1706 |
2055 | CLN8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 2.59e-01 | -0.2061 |
2055 | CLN8 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 2.45e-01 | -0.0842 |
2055 | CLN8 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | 1.98e-01 | -0.0179 |
2055 | CLN8 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.76e-05 | 1.30e-01 | 0.096 |
2055 | CLN8 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 2.05e-01 | 0.0528 |
2055 | CLN8 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.36e-03 | 2.26e-01 | -0.0177 |
2055 | CLN8 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.28e-04 | 2.21e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00325351 | Colorectum | SER | regulation of cellular component size | 115/2897 | 383/18723 | 3.04e-13 | 1.10e-10 | 115 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
GO:00070061 | Colorectum | SER | mitochondrial membrane organization | 38/2897 | 116/18723 | 2.66e-06 | 1.10e-04 | 38 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLN8 | SNV | Missense_Mutation | rs143701028 | c.323C>T | p.Thr108Met | p.T108M | Q9UBY8 | protein_coding | deleterious(0.05) | benign(0.318) | TCGA-P3-A5QE-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CLN8 | SNV | Missense_Mutation | novel | c.554C>G | p.Ser185Cys | p.S185C | Q9UBY8 | protein_coding | deleterious(0.05) | benign(0.018) | TCGA-Y6-A8TL-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
CLN8 | SNV | Missense_Mutation | c.694N>C | p.Thr232Pro | p.T232P | Q9UBY8 | protein_coding | tolerated(0.07) | benign(0.105) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLN8 | SNV | Missense_Mutation | novel | c.550T>G | p.Trp184Gly | p.W184G | Q9UBY8 | protein_coding | tolerated(0.23) | benign(0.265) | TCGA-BR-8366-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLN8 | SNV | Missense_Mutation | c.84G>T | p.Met28Ile | p.M28I | Q9UBY8 | protein_coding | tolerated(0.98) | benign(0) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CLN8 | SNV | Missense_Mutation | novel | c.592A>G | p.Ile198Val | p.I198V | Q9UBY8 | protein_coding | tolerated(0.47) | benign(0.103) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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