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Gene: CLDN12 |
Gene summary for CLDN12 |
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Gene information | Species | Human | Gene symbol | CLDN12 | Gene ID | 9069 |
Gene name | claudin 12 | |
Gene Alias | CLDN12 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | B2R687 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9069 | CLDN12 | LZE20T | Human | Esophagus | ESCC | 7.24e-03 | 1.47e-02 | 0.0662 |
9069 | CLDN12 | LZE24T | Human | Esophagus | ESCC | 8.08e-05 | 1.30e-01 | 0.0596 |
9069 | CLDN12 | P2T-E | Human | Esophagus | ESCC | 1.39e-11 | 1.45e-01 | 0.1177 |
9069 | CLDN12 | P4T-E | Human | Esophagus | ESCC | 8.00e-11 | 2.30e-01 | 0.1323 |
9069 | CLDN12 | P5T-E | Human | Esophagus | ESCC | 1.41e-07 | 1.73e-02 | 0.1327 |
9069 | CLDN12 | P8T-E | Human | Esophagus | ESCC | 1.25e-23 | 2.40e-01 | 0.0889 |
9069 | CLDN12 | P9T-E | Human | Esophagus | ESCC | 8.05e-12 | 1.12e-01 | 0.1131 |
9069 | CLDN12 | P10T-E | Human | Esophagus | ESCC | 3.97e-10 | 1.24e-01 | 0.116 |
9069 | CLDN12 | P11T-E | Human | Esophagus | ESCC | 4.72e-05 | 2.73e-01 | 0.1426 |
9069 | CLDN12 | P12T-E | Human | Esophagus | ESCC | 1.18e-09 | 2.60e-01 | 0.1122 |
9069 | CLDN12 | P15T-E | Human | Esophagus | ESCC | 8.84e-12 | 2.55e-01 | 0.1149 |
9069 | CLDN12 | P16T-E | Human | Esophagus | ESCC | 2.79e-72 | 1.30e+00 | 0.1153 |
9069 | CLDN12 | P19T-E | Human | Esophagus | ESCC | 4.92e-04 | 2.89e-01 | 0.1662 |
9069 | CLDN12 | P20T-E | Human | Esophagus | ESCC | 1.78e-10 | 1.69e-01 | 0.1124 |
9069 | CLDN12 | P21T-E | Human | Esophagus | ESCC | 2.40e-19 | 1.92e-01 | 0.1617 |
9069 | CLDN12 | P22T-E | Human | Esophagus | ESCC | 3.00e-10 | 3.28e-02 | 0.1236 |
9069 | CLDN12 | P23T-E | Human | Esophagus | ESCC | 1.46e-18 | 4.61e-01 | 0.108 |
9069 | CLDN12 | P24T-E | Human | Esophagus | ESCC | 4.25e-11 | 4.66e-02 | 0.1287 |
9069 | CLDN12 | P26T-E | Human | Esophagus | ESCC | 7.78e-14 | 2.06e-01 | 0.1276 |
9069 | CLDN12 | P27T-E | Human | Esophagus | ESCC | 1.63e-08 | 7.11e-02 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003563310 | Esophagus | ESCC | maintenance of blood-brain barrier | 24/8552 | 35/18723 | 5.25e-03 | 1.97e-02 | 24 |
GO:003563315 | Prostate | Tumor | maintenance of blood-brain barrier | 17/3246 | 35/18723 | 2.09e-05 | 2.71e-04 | 17 |
GO:000189416 | Prostate | Tumor | tissue homeostasis | 65/3246 | 268/18723 | 2.39e-03 | 1.35e-02 | 65 |
GO:006024915 | Prostate | Tumor | anatomical structure homeostasis | 74/3246 | 314/18723 | 2.82e-03 | 1.54e-02 | 74 |
GO:003563319 | Thyroid | PTC | maintenance of blood-brain barrier | 19/5968 | 35/18723 | 4.94e-03 | 2.29e-02 | 19 |
GO:003563322 | Thyroid | ATC | maintenance of blood-brain barrier | 22/6293 | 35/18723 | 3.74e-04 | 2.28e-03 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLDN12 | SNV | Missense_Mutation | rs775546156 | c.407N>T | p.Ala136Val | p.A136V | P56749 | protein_coding | deleterious(0) | benign(0.424) | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
CLDN12 | SNV | Missense_Mutation | rs200372770 | c.11N>A | p.Arg4Gln | p.R4Q | P56749 | protein_coding | tolerated_low_confidence(0.1) | benign(0.014) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
CLDN12 | SNV | Missense_Mutation | rs750382986 | c.289G>A | p.Ala97Thr | p.A97T | P56749 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLDN12 | SNV | Missense_Mutation | c.13N>A | p.Asp5Asn | p.D5N | P56749 | protein_coding | tolerated_low_confidence(0.11) | benign(0.325) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLDN12 | SNV | Missense_Mutation | c.544G>T | p.Ala182Ser | p.A182S | P56749 | protein_coding | tolerated(0.38) | benign(0) | TCGA-22-5489-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | taxotere | PD | |
CLDN12 | SNV | Missense_Mutation | c.651G>T | p.Met217Ile | p.M217I | P56749 | protein_coding | tolerated(0.37) | benign(0.006) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLDN12 | SNV | Missense_Mutation | c.434N>G | p.Thr145Ser | p.T145S | P56749 | protein_coding | tolerated(0.06) | benign(0) | TCGA-46-3768-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
CLDN12 | SNV | Missense_Mutation | novel | c.457N>C | p.Trp153Arg | p.W153R | P56749 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-56-A49D-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CLDN12 | SNV | Missense_Mutation | novel | c.691N>C | p.Ser231Pro | p.S231P | P56749 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
CLDN12 | SNV | Missense_Mutation | novel | c.334N>A | p.Ala112Thr | p.A112T | P56749 | protein_coding | tolerated(0.39) | benign(0.013) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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