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Gene: CHMP4B |
Gene summary for CHMP4B |
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Gene information | Species | Human | Gene symbol | CHMP4B | Gene ID | 128866 |
Gene name | charged multivesicular body protein 4B | |
Gene Alias | C20orf178 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9H444 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128866 | CHMP4B | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.95e-11 | 6.88e-01 | -0.1808 |
128866 | CHMP4B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.56e-16 | 8.06e-01 | -0.0811 |
128866 | CHMP4B | HTA11_78_2000001011 | Human | Colorectum | AD | 4.62e-03 | 3.58e-01 | -0.1088 |
128866 | CHMP4B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.59e-24 | 7.42e-01 | -0.1954 |
128866 | CHMP4B | HTA11_411_2000001011 | Human | Colorectum | SER | 6.15e-06 | 1.01e+00 | -0.2602 |
128866 | CHMP4B | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.13e-09 | 1.10e+00 | -0.2196 |
128866 | CHMP4B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.27e-11 | 7.05e-01 | -0.1207 |
128866 | CHMP4B | HTA11_83_2000001011 | Human | Colorectum | SER | 5.50e-07 | 6.11e-01 | -0.1526 |
128866 | CHMP4B | HTA11_696_2000001011 | Human | Colorectum | AD | 2.42e-19 | 7.06e-01 | -0.1464 |
128866 | CHMP4B | HTA11_866_2000001011 | Human | Colorectum | AD | 5.60e-04 | 3.80e-01 | -0.1001 |
128866 | CHMP4B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-19 | 7.60e-01 | -0.059 |
128866 | CHMP4B | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.56e-08 | 8.82e-01 | -0.1706 |
128866 | CHMP4B | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.49e-13 | 1.18e+00 | -0.2061 |
128866 | CHMP4B | HTA11_546_2000001011 | Human | Colorectum | AD | 4.89e-04 | 4.43e-01 | -0.0842 |
128866 | CHMP4B | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.18e-05 | 4.98e-01 | -0.0179 |
128866 | CHMP4B | HTA11_866_3004761011 | Human | Colorectum | AD | 3.04e-21 | 7.88e-01 | 0.096 |
128866 | CHMP4B | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.16e-03 | 4.47e-01 | 0.0528 |
128866 | CHMP4B | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.98e-06 | 8.20e-01 | 0.0131 |
128866 | CHMP4B | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.57e-03 | 4.66e-01 | -0.0177 |
128866 | CHMP4B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.69e-03 | 3.71e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0006900 | Colorectum | AD | vesicle budding from membrane | 32/3918 | 61/18723 | 5.38e-08 | 2.81e-06 | 32 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa03250 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa032501 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP4B | SNV | Missense_Mutation | novel | c.223N>C | p.Tyr75His | p.Y75H | Q9H444 | protein_coding | tolerated(0.1) | benign(0.3) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP4B | SNV | Missense_Mutation | novel | c.642N>C | p.Met214Ile | p.M214I | Q9H444 | protein_coding | tolerated(0.16) | benign(0.017) | TCGA-YL-A8S9-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD |
CHMP4B | insertion | Frame_Shift_Ins | novel | c.67dupC | p.Gln23ProfsTer50 | p.Q23Pfs*50 | Q9H444 | protein_coding | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | ||
CHMP4B | SNV | Missense_Mutation | rs769262650 | c.610N>T | p.Ala204Ser | p.A204S | Q9H444 | protein_coding | tolerated(0.56) | benign(0.11) | TCGA-EM-A2CJ-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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