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Gene: CHD1 |
Gene summary for CHD1 |
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Gene information | Species | Human | Gene symbol | CHD1 | Gene ID | 1105 |
Gene name | chromodomain helicase DNA binding protein 1 | |
Gene Alias | CHD-1 | |
Cytomap | 5q15-q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KT33 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1105 | CHD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.48e-22 | -6.83e-01 | 0.0155 |
1105 | CHD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.48e-09 | -6.00e-01 | -0.1808 |
1105 | CHD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.76e-04 | -7.72e-01 | 0.0216 |
1105 | CHD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-06 | -5.97e-01 | -0.0811 |
1105 | CHD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.48e-05 | -5.49e-01 | -0.1207 |
1105 | CHD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.01e-18 | -5.63e-01 | -0.1464 |
1105 | CHD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.37e-11 | -4.47e-01 | -0.1001 |
1105 | CHD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.93e-09 | -4.74e-01 | -0.059 |
1105 | CHD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.14e-02 | -5.92e-01 | -0.1706 |
1105 | CHD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.59e-03 | -6.36e-01 | -0.2061 |
1105 | CHD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.62e-02 | -6.75e-01 | -0.1462 |
1105 | CHD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.34e-05 | -6.65e-01 | -0.0179 |
1105 | CHD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.89e-16 | -6.17e-01 | 0.096 |
1105 | CHD1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.83e-04 | -6.89e-01 | 0.0528 |
1105 | CHD1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.65e-04 | -6.00e-01 | -0.0177 |
1105 | CHD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.91e-09 | -6.13e-01 | 0.0338 |
1105 | CHD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.64e-18 | -5.58e-01 | 0.0674 |
1105 | CHD1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.19e-03 | -5.68e-01 | 0.0112 |
1105 | CHD1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.45e-04 | -5.06e-01 | 0.0588 |
1105 | CHD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.00e-16 | -4.87e-01 | 0.294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:000611910 | Cervix | CC | oxidative phosphorylation | 55/2311 | 141/18723 | 7.12e-16 | 1.42e-12 | 55 |
GO:00090609 | Cervix | CC | aerobic respiration | 60/2311 | 189/18723 | 1.59e-12 | 6.36e-10 | 60 |
GO:00453339 | Cervix | CC | cellular respiration | 66/2311 | 230/18723 | 2.07e-11 | 5.39e-09 | 66 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:00325077 | Cervix | CC | maintenance of protein location in cell | 21/2311 | 65/18723 | 2.03e-05 | 3.71e-04 | 21 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00108218 | Cervix | CC | regulation of mitochondrion organization | 34/2311 | 144/18723 | 1.27e-04 | 1.58e-03 | 34 |
GO:20010209 | Cervix | CC | regulation of response to DNA damage stimulus | 46/2311 | 219/18723 | 1.92e-04 | 2.23e-03 | 46 |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00725955 | Cervix | CC | maintenance of protein localization in organelle | 14/2311 | 42/18723 | 3.32e-04 | 3.49e-03 | 14 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:00086379 | Cervix | CC | apoptotic mitochondrial changes | 25/2311 | 107/18723 | 1.11e-03 | 9.14e-03 | 25 |
GO:00108224 | Cervix | CC | positive regulation of mitochondrion organization | 19/2311 | 74/18723 | 1.30e-03 | 1.03e-02 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHD1 | SNV | Missense_Mutation | c.4882N>T | p.His1628Tyr | p.H1628Y | O14646 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CHD1 | deletion | Frame_Shift_Del | novel | c.3992_3993delGG | p.Arg1331LysfsTer6 | p.R1331Kfs*6 | O14646 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
CHD1 | insertion | In_Frame_Ins | novel | c.3991_3992insACT | p.Arg1331delinsAsnTrp | p.R1331delinsNW | O14646 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
CHD1 | SNV | Missense_Mutation | c.2441T>C | p.Val814Ala | p.V814A | O14646 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD1 | SNV | Missense_Mutation | c.3313G>A | p.Glu1105Lys | p.E1105K | O14646 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD1 | SNV | Missense_Mutation | rs768739262 | c.3358C>T | p.Arg1120Trp | p.R1120W | O14646 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHD1 | SNV | Missense_Mutation | novel | c.3335N>A | p.Arg1112His | p.R1112H | O14646 | protein_coding | deleterious(0) | benign(0.425) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHD1 | SNV | Missense_Mutation | c.4832G>T | p.Arg1611Met | p.R1611M | O14646 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.459) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHD1 | SNV | Missense_Mutation | c.3566G>A | p.Arg1189Gln | p.R1189Q | O14646 | protein_coding | tolerated(0.34) | benign(0.018) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHD1 | SNV | Missense_Mutation | c.1495N>A | p.Gly499Arg | p.G499R | O14646 | protein_coding | tolerated(0.13) | benign(0.062) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1105 | CHD1 | NA | EPIRUBICIN | EPIRUBICIN | ||
1105 | CHD1 | NA | EPIRUBICIN | EPIRUBICIN |
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