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Gene: CGRRF1 |
Gene summary for CGRRF1 |
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Gene information | Species | Human | Gene symbol | CGRRF1 | Gene ID | 10668 |
Gene name | cell growth regulator with ring finger domain 1 | |
Gene Alias | CGR19 | |
Cytomap | 14q22.2 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q99675 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10668 | CGRRF1 | LZE4T | Human | Esophagus | ESCC | 4.26e-03 | 1.66e-01 | 0.0811 |
10668 | CGRRF1 | LZE5T | Human | Esophagus | ESCC | 5.52e-03 | 1.66e-01 | 0.0514 |
10668 | CGRRF1 | LZE24T | Human | Esophagus | ESCC | 1.26e-10 | 1.89e-01 | 0.0596 |
10668 | CGRRF1 | P2T-E | Human | Esophagus | ESCC | 3.64e-12 | 1.40e-01 | 0.1177 |
10668 | CGRRF1 | P4T-E | Human | Esophagus | ESCC | 2.86e-17 | 3.53e-01 | 0.1323 |
10668 | CGRRF1 | P5T-E | Human | Esophagus | ESCC | 9.09e-08 | 5.68e-02 | 0.1327 |
10668 | CGRRF1 | P8T-E | Human | Esophagus | ESCC | 1.99e-19 | 2.04e-01 | 0.0889 |
10668 | CGRRF1 | P9T-E | Human | Esophagus | ESCC | 6.11e-06 | 8.55e-02 | 0.1131 |
10668 | CGRRF1 | P10T-E | Human | Esophagus | ESCC | 2.29e-21 | 2.40e-01 | 0.116 |
10668 | CGRRF1 | P11T-E | Human | Esophagus | ESCC | 7.00e-13 | 3.19e-01 | 0.1426 |
10668 | CGRRF1 | P12T-E | Human | Esophagus | ESCC | 1.49e-22 | 3.98e-01 | 0.1122 |
10668 | CGRRF1 | P15T-E | Human | Esophagus | ESCC | 1.81e-16 | 3.39e-01 | 0.1149 |
10668 | CGRRF1 | P16T-E | Human | Esophagus | ESCC | 3.37e-16 | 1.46e-01 | 0.1153 |
10668 | CGRRF1 | P20T-E | Human | Esophagus | ESCC | 3.99e-17 | 2.34e-01 | 0.1124 |
10668 | CGRRF1 | P21T-E | Human | Esophagus | ESCC | 1.42e-17 | 1.72e-01 | 0.1617 |
10668 | CGRRF1 | P22T-E | Human | Esophagus | ESCC | 1.54e-18 | 1.65e-01 | 0.1236 |
10668 | CGRRF1 | P23T-E | Human | Esophagus | ESCC | 1.41e-07 | 6.19e-02 | 0.108 |
10668 | CGRRF1 | P24T-E | Human | Esophagus | ESCC | 3.28e-12 | 1.38e-01 | 0.1287 |
10668 | CGRRF1 | P26T-E | Human | Esophagus | ESCC | 1.82e-25 | 5.22e-01 | 0.1276 |
10668 | CGRRF1 | P27T-E | Human | Esophagus | ESCC | 2.15e-28 | 4.43e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:00303085 | Esophagus | ESCC | negative regulation of cell growth | 108/8552 | 188/18723 | 7.46e-04 | 3.87e-03 | 108 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:00459266 | Oral cavity | OSCC | negative regulation of growth | 135/7305 | 249/18723 | 7.29e-07 | 1.03e-05 | 135 |
GO:00303084 | Oral cavity | OSCC | negative regulation of cell growth | 101/7305 | 188/18723 | 2.85e-05 | 2.63e-04 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CGRRF1 | SNV | Missense_Mutation | novel | c.320N>C | p.Leu107Ser | p.L107S | Q99675 | protein_coding | deleterious(0) | possibly_damaging(0.57) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CGRRF1 | SNV | Missense_Mutation | novel | c.863N>A | p.Pro288Gln | p.P288Q | Q99675 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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