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Gene: CFI |
Gene summary for CFI |
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Gene information | Species | Human | Gene symbol | CFI | Gene ID | 3426 |
Gene name | complement factor I | |
Gene Alias | AHUS3 | |
Cytomap | 4q25 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | A8K3L0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3426 | CFI | LZE8T | Human | Esophagus | ESCC | 1.53e-09 | 3.85e-01 | 0.067 |
3426 | CFI | P2T-E | Human | Esophagus | ESCC | 1.28e-08 | 6.77e-02 | 0.1177 |
3426 | CFI | P4T-E | Human | Esophagus | ESCC | 3.87e-02 | 5.70e-02 | 0.1323 |
3426 | CFI | P8T-E | Human | Esophagus | ESCC | 3.59e-13 | 2.83e-01 | 0.0889 |
3426 | CFI | P9T-E | Human | Esophagus | ESCC | 1.00e-07 | 7.65e-02 | 0.1131 |
3426 | CFI | P11T-E | Human | Esophagus | ESCC | 6.77e-11 | 3.80e-01 | 0.1426 |
3426 | CFI | P17T-E | Human | Esophagus | ESCC | 3.53e-02 | 4.10e-01 | 0.1278 |
3426 | CFI | P24T-E | Human | Esophagus | ESCC | 4.02e-02 | 1.93e-01 | 0.1287 |
3426 | CFI | P32T-E | Human | Esophagus | ESCC | 8.55e-13 | 2.72e-01 | 0.1666 |
3426 | CFI | P36T-E | Human | Esophagus | ESCC | 1.65e-03 | 2.95e-01 | 0.1187 |
3426 | CFI | P37T-E | Human | Esophagus | ESCC | 3.55e-11 | 2.30e-01 | 0.1371 |
3426 | CFI | P40T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.46e-01 | 0.109 |
3426 | CFI | P44T-E | Human | Esophagus | ESCC | 1.27e-14 | 4.56e-01 | 0.1096 |
3426 | CFI | P47T-E | Human | Esophagus | ESCC | 9.86e-06 | 1.17e-01 | 0.1067 |
3426 | CFI | P48T-E | Human | Esophagus | ESCC | 8.15e-03 | 9.76e-02 | 0.0959 |
3426 | CFI | P52T-E | Human | Esophagus | ESCC | 9.26e-05 | 2.47e-01 | 0.1555 |
3426 | CFI | P57T-E | Human | Esophagus | ESCC | 1.17e-09 | 3.56e-01 | 0.0926 |
3426 | CFI | P61T-E | Human | Esophagus | ESCC | 8.21e-13 | 2.31e-01 | 0.099 |
3426 | CFI | P62T-E | Human | Esophagus | ESCC | 5.25e-16 | 3.99e-01 | 0.1302 |
3426 | CFI | P74T-E | Human | Esophagus | ESCC | 1.26e-17 | 5.65e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFI | SNV | Missense_Mutation | rs746566803 | c.1058N>A | p.Arg353Gln | p.R353Q | protein_coding | tolerated(0.54) | benign(0.094) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | ||
CFI | SNV | Missense_Mutation | rs773085612 | c.1040G>A | p.Arg347Gln | p.R347Q | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
CFI | insertion | Frame_Shift_Ins | novel | c.1670dupA | p.Asn557LysfsTer19 | p.N557Kfs*19 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
CFI | deletion | Frame_Shift_Del | c.111delN | p.Lys37AsnfsTer65 | p.K37Nfs*65 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||||
CFI | SNV | Missense_Mutation | novel | c.322G>A | p.Ala108Thr | p.A108T | protein_coding | tolerated(0.48) | benign(0.113) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFI | SNV | Missense_Mutation | rs181729783 | c.1240N>T | p.Arg414Cys | p.R414C | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFI | SNV | Missense_Mutation | c.1019N>T | p.Arg340Ile | p.R340I | protein_coding | tolerated(0.37) | benign(0.024) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CFI | SNV | Missense_Mutation | rs763276049 | c.1429N>A | p.Val477Ile | p.V477I | protein_coding | tolerated(0.63) | benign(0.043) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFI | SNV | Missense_Mutation | c.1459N>A | p.Glu487Lys | p.E487K | protein_coding | tolerated(0.95) | benign(0.003) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
CFI | SNV | Missense_Mutation | novel | c.290G>A | p.Gly97Glu | p.G97E | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3426 | CFI | ENZYME, DRUGGABLE GENOME, PROTEASE | TGFBETA1 | 17320177 |
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