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Gene: CFAP221 |
Gene summary for CFAP221 |
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Gene information | Species | Human | Gene symbol | CFAP221 | Gene ID | 200373 |
Gene name | cilia and flagella associated protein 221 | |
Gene Alias | FAP221 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | Q4G0U5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200373 | CFAP221 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 2.32e-02 | 8.56e-01 | -0.1271 |
200373 | CFAP221 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.56e-04 | 8.42e-01 | -0.1406 |
200373 | CFAP221 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.64e-02 | 7.39e-01 | -0.1408 |
200373 | CFAP221 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.41e-02 | 6.75e-01 | -0.138 |
200373 | CFAP221 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.53e-18 | 8.74e-01 | -0.2116 |
200373 | CFAP221 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.12e-05 | 7.65e-01 | -0.1941 |
200373 | CFAP221 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.52e-07 | 7.76e-01 | -0.2107 |
200373 | CFAP221 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.45e-10 | 7.57e-01 | -0.2119 |
200373 | CFAP221 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.19e-30 | 9.14e-01 | -0.0166 |
200373 | CFAP221 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.11e-38 | 1.02e+00 | -0.0132 |
200373 | CFAP221 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.66e-37 | 9.49e-01 | -0.013 |
200373 | CFAP221 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.74e-26 | 8.55e-01 | -0.0121 |
200373 | CFAP221 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.98e-12 | 9.68e-01 | -0.0961 |
200373 | CFAP221 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.88e-12 | 8.56e-01 | -0.0876 |
200373 | CFAP221 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.56e-09 | 8.56e-01 | -0.0822 |
200373 | CFAP221 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.11e-10 | 8.87e-01 | -0.0809 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP221 | SNV | Missense_Mutation | rs185475282 | c.272N>A | p.Arg91His | p.R91H | Q4G0U5 | protein_coding | tolerated(0.64) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | c.1339N>T | p.Asp447Tyr | p.D447Y | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | c.2405N>T | p.Arg802Met | p.R802M | Q4G0U5 | protein_coding | deleterious(0.01) | benign(0.024) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | c.1358C>A | p.Thr453Asn | p.T453N | Q4G0U5 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | rs774688531 | c.1289N>A | p.Arg430Gln | p.R430Q | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0L8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CFAP221 | SNV | Missense_Mutation | rs140592618 | c.1546N>T | p.Arg516Trp | p.R516W | Q4G0U5 | protein_coding | deleterious(0.03) | possibly_damaging(0.533) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.644N>T | p.Ala215Val | p.A215V | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.868N>C | p.Asn290His | p.N290H | Q4G0U5 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.191N>C | p.Ile64Thr | p.I64T | Q4G0U5 | protein_coding | deleterious(0) | benign(0.102) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.392N>A | p.Arg131Gln | p.R131Q | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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