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Gene: CEP57L1 |
Gene summary for CEP57L1 |
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Gene information | Species | Human | Gene symbol | CEP57L1 | Gene ID | 285753 |
Gene name | centrosomal protein 57 like 1 | |
Gene Alias | C6orf182 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8IYX8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285753 | CEP57L1 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 1.05e-01 | 0.0596 |
285753 | CEP57L1 | P2T-E | Human | Esophagus | ESCC | 2.70e-10 | 2.62e-01 | 0.1177 |
285753 | CEP57L1 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.68e-01 | 0.1323 |
285753 | CEP57L1 | P5T-E | Human | Esophagus | ESCC | 3.52e-04 | 1.11e-01 | 0.1327 |
285753 | CEP57L1 | P8T-E | Human | Esophagus | ESCC | 2.88e-06 | 8.82e-02 | 0.0889 |
285753 | CEP57L1 | P10T-E | Human | Esophagus | ESCC | 5.71e-06 | 1.36e-01 | 0.116 |
285753 | CEP57L1 | P12T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.55e-01 | 0.1122 |
285753 | CEP57L1 | P15T-E | Human | Esophagus | ESCC | 3.26e-02 | 7.75e-02 | 0.1149 |
285753 | CEP57L1 | P16T-E | Human | Esophagus | ESCC | 1.65e-07 | 1.72e-01 | 0.1153 |
285753 | CEP57L1 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.58e-01 | 0.1278 |
285753 | CEP57L1 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 2.99e-01 | 0.1662 |
285753 | CEP57L1 | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 1.12e-01 | 0.1124 |
285753 | CEP57L1 | P21T-E | Human | Esophagus | ESCC | 3.58e-10 | 1.65e-01 | 0.1617 |
285753 | CEP57L1 | P22T-E | Human | Esophagus | ESCC | 2.62e-05 | 7.38e-02 | 0.1236 |
285753 | CEP57L1 | P24T-E | Human | Esophagus | ESCC | 2.90e-08 | 1.73e-01 | 0.1287 |
285753 | CEP57L1 | P26T-E | Human | Esophagus | ESCC | 1.91e-08 | 1.32e-01 | 0.1276 |
285753 | CEP57L1 | P27T-E | Human | Esophagus | ESCC | 2.68e-09 | 1.70e-01 | 0.1055 |
285753 | CEP57L1 | P28T-E | Human | Esophagus | ESCC | 3.60e-08 | 1.55e-01 | 0.1149 |
285753 | CEP57L1 | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 1.73e-01 | 0.137 |
285753 | CEP57L1 | P31T-E | Human | Esophagus | ESCC | 6.30e-03 | 1.24e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP57L1 | SNV | Missense_Mutation | novel | c.683A>C | p.Lys228Thr | p.K228T | Q8IYX8 | protein_coding | deleterious(0.02) | possibly_damaging(0.505) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CEP57L1 | SNV | Missense_Mutation | novel | c.1063N>G | p.Ser355Ala | p.S355A | Q8IYX8 | protein_coding | tolerated(0.51) | benign(0.015) | TCGA-DD-AACX-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CEP57L1 | SNV | Missense_Mutation | rs565910794 | c.417G>T | p.Met139Ile | p.M139I | Q8IYX8 | protein_coding | deleterious(0.01) | possibly_damaging(0.908) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
CEP57L1 | SNV | Missense_Mutation | c.343A>G | p.Ile115Val | p.I115V | Q8IYX8 | protein_coding | tolerated(0.5) | benign(0.268) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | |
CEP57L1 | SNV | Missense_Mutation | c.673N>C | p.Glu225Gln | p.E225Q | Q8IYX8 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CEP57L1 | SNV | Missense_Mutation | rs764390366 | c.842C>T | p.Pro281Leu | p.P281L | Q8IYX8 | protein_coding | tolerated(0.25) | benign(0.018) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CEP57L1 | SNV | Missense_Mutation | rs570190412 | c.374G>A | p.Arg125His | p.R125H | Q8IYX8 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
CEP57L1 | SNV | Missense_Mutation | novel | c.1109A>G | p.Lys370Arg | p.K370R | Q8IYX8 | protein_coding | tolerated(0.37) | probably_damaging(0.934) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CEP57L1 | SNV | Missense_Mutation | c.601N>A | p.Glu201Lys | p.E201K | Q8IYX8 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
CEP57L1 | SNV | Missense_Mutation | c.601N>C | p.Glu201Gln | p.E201Q | Q8IYX8 | protein_coding | tolerated(0.2) | possibly_damaging(0.841) | TCGA-58-8393-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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