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Gene: CEP104 |
Gene summary for CEP104 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CEP104 | Gene ID | 9731 |
Gene name | centrosomal protein 104 | |
Gene Alias | CFAP256 | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0000922 | UniProtAcc | O60308 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9731 | CEP104 | LZE2T | Human | Esophagus | ESCC | 4.93e-06 | 4.18e-01 | 0.082 |
9731 | CEP104 | LZE4T | Human | Esophagus | ESCC | 2.81e-06 | 1.84e-01 | 0.0811 |
9731 | CEP104 | LZE7T | Human | Esophagus | ESCC | 3.70e-04 | 1.84e-01 | 0.0667 |
9731 | CEP104 | LZE20T | Human | Esophagus | ESCC | 1.68e-05 | 2.03e-01 | 0.0662 |
9731 | CEP104 | LZE22T | Human | Esophagus | ESCC | 5.36e-04 | 3.15e-01 | 0.068 |
9731 | CEP104 | LZE24T | Human | Esophagus | ESCC | 9.95e-16 | 4.20e-01 | 0.0596 |
9731 | CEP104 | P1T-E | Human | Esophagus | ESCC | 1.23e-03 | 3.17e-01 | 0.0875 |
9731 | CEP104 | P2T-E | Human | Esophagus | ESCC | 3.28e-31 | 5.46e-01 | 0.1177 |
9731 | CEP104 | P4T-E | Human | Esophagus | ESCC | 1.31e-27 | 6.20e-01 | 0.1323 |
9731 | CEP104 | P5T-E | Human | Esophagus | ESCC | 1.19e-12 | 2.22e-01 | 0.1327 |
9731 | CEP104 | P8T-E | Human | Esophagus | ESCC | 5.40e-25 | 4.79e-01 | 0.0889 |
9731 | CEP104 | P9T-E | Human | Esophagus | ESCC | 1.91e-08 | 2.05e-01 | 0.1131 |
9731 | CEP104 | P10T-E | Human | Esophagus | ESCC | 3.15e-23 | 4.85e-01 | 0.116 |
9731 | CEP104 | P11T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.93e-01 | 0.1426 |
9731 | CEP104 | P12T-E | Human | Esophagus | ESCC | 2.40e-16 | 3.08e-01 | 0.1122 |
9731 | CEP104 | P15T-E | Human | Esophagus | ESCC | 1.65e-17 | 3.43e-01 | 0.1149 |
9731 | CEP104 | P16T-E | Human | Esophagus | ESCC | 3.39e-25 | 2.90e-01 | 0.1153 |
9731 | CEP104 | P17T-E | Human | Esophagus | ESCC | 2.19e-06 | 2.82e-01 | 0.1278 |
9731 | CEP104 | P19T-E | Human | Esophagus | ESCC | 1.38e-05 | 5.50e-01 | 0.1662 |
9731 | CEP104 | P20T-E | Human | Esophagus | ESCC | 2.63e-22 | 4.41e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP104 | SNV | Missense_Mutation | novel | c.1708T>A | p.Tyr570Asn | p.Y570N | O60308 | protein_coding | tolerated(0.25) | possibly_damaging(0.503) | TCGA-AG-4015-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | rs754082531 | c.1162C>T | p.Arg388Cys | p.R388C | O60308 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | c.1181C>T | p.Ala394Val | p.A394V | O60308 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
CEP104 | SNV | Missense_Mutation | rs779566424 | c.82N>A | p.Ala28Thr | p.A28T | O60308 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EI-6881-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5 | SD |
CEP104 | SNV | Missense_Mutation | rs754082531 | c.1162N>T | p.Arg388Cys | p.R388C | O60308 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CEP104 | SNV | Missense_Mutation | novel | c.2222N>T | p.Ala741Val | p.A741V | O60308 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | novel | c.1289N>A | p.Ser430Tyr | p.S430Y | O60308 | protein_coding | tolerated(0.8) | benign(0.178) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | novel | c.557N>T | p.Thr186Met | p.T186M | O60308 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | novel | c.139N>A | p.Val47Ile | p.V47I | O60308 | protein_coding | tolerated(0.46) | benign(0.038) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEP104 | SNV | Missense_Mutation | novel | c.1046N>A | p.Ser349Tyr | p.S349Y | O60308 | protein_coding | deleterious(0.04) | benign(0.347) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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