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Gene: CEACAM6 |
Gene summary for CEACAM6 |
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Gene information | Species | Human | Gene symbol | CEACAM6 | Gene ID | 4680 |
Gene name | CEA cell adhesion molecule 6 | |
Gene Alias | CD66c | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001952 | UniProtAcc | P40199 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4680 | CEACAM6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.49e-05 | -3.34e-01 | 0.0155 |
4680 | CEACAM6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.28e-04 | -2.93e-01 | 0.0674 |
4680 | CEACAM6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.57e-06 | -2.91e-01 | 0.294 |
4680 | CEACAM6 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.13e-08 | 1.23e+00 | 0.281 |
4680 | CEACAM6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.74e-08 | 7.54e-01 | 0.3859 |
4680 | CEACAM6 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.49e-17 | 1.55e+00 | 0.2585 |
4680 | CEACAM6 | A015-C-203 | Human | Colorectum | FAP | 1.28e-07 | -2.82e-01 | -0.1294 |
4680 | CEACAM6 | A001-C-119 | Human | Colorectum | FAP | 1.07e-02 | -3.19e-01 | -0.1557 |
4680 | CEACAM6 | A002-C-205 | Human | Colorectum | FAP | 9.77e-06 | -3.17e-01 | -0.1236 |
4680 | CEACAM6 | A014-C-108 | Human | Colorectum | FAP | 1.31e-03 | -3.28e-01 | -0.124 |
4680 | CEACAM6 | A001-C-104 | Human | Colorectum | FAP | 3.29e-04 | -2.69e-01 | 0.0184 |
4680 | CEACAM6 | A015-C-006 | Human | Colorectum | FAP | 2.14e-03 | -3.22e-01 | -0.0994 |
4680 | CEACAM6 | A015-C-106 | Human | Colorectum | FAP | 3.28e-04 | -2.59e-01 | -0.0511 |
4680 | CEACAM6 | A002-C-114 | Human | Colorectum | FAP | 7.47e-03 | -2.71e-01 | -0.1561 |
4680 | CEACAM6 | A015-C-104 | Human | Colorectum | FAP | 6.27e-09 | -3.09e-01 | -0.1899 |
4680 | CEACAM6 | A015-C-202 | Human | Colorectum | FAP | 2.33e-09 | -3.45e-01 | -0.0849 |
4680 | CEACAM6 | A001-C-014 | Human | Colorectum | FAP | 1.06e-04 | -2.22e-01 | 0.0135 |
4680 | CEACAM6 | A002-C-016 | Human | Colorectum | FAP | 4.35e-02 | -9.82e-02 | 0.0521 |
4680 | CEACAM6 | A001-C-203 | Human | Colorectum | FAP | 2.42e-07 | -3.17e-01 | -0.0481 |
4680 | CEACAM6 | A002-C-116 | Human | Colorectum | FAP | 2.63e-06 | -2.42e-01 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010811 | Colorectum | AD | positive regulation of cell-substrate adhesion | 53/3918 | 123/18723 | 2.30e-08 | 1.27e-06 | 53 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0001952 | Colorectum | AD | regulation of cell-matrix adhesion | 50/3918 | 128/18723 | 2.05e-06 | 6.05e-05 | 50 |
GO:0001954 | Colorectum | AD | positive regulation of cell-matrix adhesion | 27/3918 | 58/18723 | 1.12e-05 | 2.55e-04 | 27 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:00108102 | Colorectum | MSS | regulation of cell-substrate adhesion | 73/3467 | 221/18723 | 1.56e-07 | 7.16e-06 | 73 |
GO:00108112 | Colorectum | MSS | positive regulation of cell-substrate adhesion | 47/3467 | 123/18723 | 2.28e-07 | 9.79e-06 | 47 |
GO:00315892 | Colorectum | MSS | cell-substrate adhesion | 104/3467 | 363/18723 | 1.35e-06 | 4.51e-05 | 104 |
GO:00019522 | Colorectum | MSS | regulation of cell-matrix adhesion | 45/3467 | 128/18723 | 5.75e-06 | 1.53e-04 | 45 |
GO:00019542 | Colorectum | MSS | positive regulation of cell-matrix adhesion | 23/3467 | 58/18723 | 1.39e-04 | 2.06e-03 | 23 |
GO:00071602 | Colorectum | MSS | cell-matrix adhesion | 65/3467 | 233/18723 | 2.77e-04 | 3.67e-03 | 65 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00108104 | Colorectum | FAP | regulation of cell-substrate adhesion | 68/2622 | 221/18723 | 9.67e-11 | 2.96e-08 | 68 |
GO:00315893 | Colorectum | FAP | cell-substrate adhesion | 93/2622 | 363/18723 | 2.48e-09 | 4.61e-07 | 93 |
GO:00108114 | Colorectum | FAP | positive regulation of cell-substrate adhesion | 43/2622 | 123/18723 | 3.82e-09 | 6.33e-07 | 43 |
GO:00019523 | Colorectum | FAP | regulation of cell-matrix adhesion | 42/2622 | 128/18723 | 4.73e-08 | 3.86e-06 | 42 |
GO:00071603 | Colorectum | FAP | cell-matrix adhesion | 63/2622 | 233/18723 | 1.13e-07 | 7.43e-06 | 63 |
GO:00019543 | Colorectum | FAP | positive regulation of cell-matrix adhesion | 22/2622 | 58/18723 | 5.19e-06 | 1.68e-04 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEACAM6 | SNV | Missense_Mutation | c.620N>T | p.Arg207Met | p.R207M | P40199 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEACAM6 | SNV | Missense_Mutation | novel | c.256N>G | p.Thr86Ala | p.T86A | P40199 | protein_coding | tolerated(0.08) | benign(0.022) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CEACAM6 | SNV | Missense_Mutation | novel | c.130N>G | p.Asn44Asp | p.N44D | P40199 | protein_coding | tolerated(0.36) | possibly_damaging(0.786) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CEACAM6 | SNV | Missense_Mutation | c.385N>A | p.Leu129Ile | p.L129I | P40199 | protein_coding | tolerated(0.39) | benign(0.23) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
CEACAM6 | insertion | Frame_Shift_Ins | novel | c.309dupC | p.Asn104GlnfsTer13 | p.N104Qfs*13 | P40199 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
CEACAM6 | SNV | Missense_Mutation | c.866N>C | p.Ile289Thr | p.I289T | P40199 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-DD-A3A5-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CEACAM6 | SNV | Missense_Mutation | novel | c.964G>T | p.Ala322Ser | p.A322S | P40199 | protein_coding | tolerated(0.85) | benign(0.003) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CEACAM6 | SNV | Missense_Mutation | c.930N>T | p.Arg310Ser | p.R310S | P40199 | protein_coding | tolerated(0.43) | benign(0.044) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
CEACAM6 | SNV | Missense_Mutation | c.706N>T | p.Gly236Cys | p.G236C | P40199 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CEACAM6 | SNV | Missense_Mutation | c.404N>A | p.Thr135Asn | p.T135N | P40199 | protein_coding | deleterious(0.01) | benign(0.099) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4680 | CEACAM6 | CELL SURFACE, DRUGGABLE GENOME | ANTISERUM | 6388310 |
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