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Gene: CDKL1 |
Gene summary for CDKL1 |
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Gene information | Species | Human | Gene symbol | CDKL1 | Gene ID | 8814 |
Gene name | cyclin dependent kinase like 1 | |
Gene Alias | KKIALRE | |
Cytomap | 14q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | J3KMW1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8814 | CDKL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.20e-03 | 3.65e-01 | -0.1954 |
8814 | CDKL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.57e-02 | -3.66e-01 | 0.096 |
8814 | CDKL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.66e-09 | -3.31e-01 | 0.294 |
8814 | CDKL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.74e-13 | -4.36e-01 | 0.3859 |
8814 | CDKL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.34e-13 | -4.30e-01 | 0.3005 |
8814 | CDKL1 | F007 | Human | Colorectum | FAP | 1.08e-03 | -3.92e-01 | 0.1176 |
8814 | CDKL1 | A002-C-010 | Human | Colorectum | FAP | 2.18e-03 | -3.00e-01 | 0.242 |
8814 | CDKL1 | A001-C-207 | Human | Colorectum | FAP | 1.44e-06 | -3.92e-01 | 0.1278 |
8814 | CDKL1 | A015-C-203 | Human | Colorectum | FAP | 5.06e-16 | -3.85e-01 | -0.1294 |
8814 | CDKL1 | A015-C-204 | Human | Colorectum | FAP | 2.59e-04 | -3.11e-01 | -0.0228 |
8814 | CDKL1 | A002-C-201 | Human | Colorectum | FAP | 2.14e-14 | -4.47e-01 | 0.0324 |
8814 | CDKL1 | A002-C-203 | Human | Colorectum | FAP | 2.52e-10 | -3.95e-01 | 0.2786 |
8814 | CDKL1 | A001-C-119 | Human | Colorectum | FAP | 1.81e-10 | -4.78e-01 | -0.1557 |
8814 | CDKL1 | A001-C-108 | Human | Colorectum | FAP | 7.07e-12 | -3.85e-01 | -0.0272 |
8814 | CDKL1 | A002-C-205 | Human | Colorectum | FAP | 5.27e-18 | -4.84e-01 | -0.1236 |
8814 | CDKL1 | A001-C-104 | Human | Colorectum | FAP | 4.38e-08 | -3.61e-01 | 0.0184 |
8814 | CDKL1 | A015-C-005 | Human | Colorectum | FAP | 1.24e-04 | -3.28e-01 | -0.0336 |
8814 | CDKL1 | A015-C-006 | Human | Colorectum | FAP | 6.64e-09 | -3.43e-01 | -0.0994 |
8814 | CDKL1 | A015-C-106 | Human | Colorectum | FAP | 5.85e-10 | -3.47e-01 | -0.0511 |
8814 | CDKL1 | A002-C-114 | Human | Colorectum | FAP | 2.09e-14 | -4.75e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:00604911 | Colorectum | MSS | regulation of cell projection assembly | 51/3467 | 188/18723 | 2.28e-03 | 1.87e-02 | 51 |
GO:01200323 | Colorectum | FAP | regulation of plasma membrane bounded cell projection assembly | 39/2622 | 186/18723 | 5.84e-03 | 3.73e-02 | 39 |
GO:00604912 | Colorectum | FAP | regulation of cell projection assembly | 39/2622 | 188/18723 | 7.01e-03 | 4.29e-02 | 39 |
GO:01200324 | Colorectum | CRC | regulation of plasma membrane bounded cell projection assembly | 35/2078 | 186/18723 | 1.22e-03 | 1.38e-02 | 35 |
GO:00604913 | Colorectum | CRC | regulation of cell projection assembly | 35/2078 | 188/18723 | 1.48e-03 | 1.58e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDKL1 | SNV | Missense_Mutation | rs748998497 | c.487G>A | p.Val163Met | p.V163M | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CDKL1 | SNV | Missense_Mutation | novel | c.619N>C | p.Ser207Pro | p.S207P | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | c.877N>A | p.Glu293Lys | p.E293K | Q00532 | protein_coding | tolerated(0.26) | benign(0.018) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDKL1 | SNV | Missense_Mutation | c.109N>A | p.Leu37Met | p.L37M | Q00532 | protein_coding | tolerated(0.11) | possibly_damaging(0.487) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDKL1 | SNV | Missense_Mutation | c.373N>T | p.His125Tyr | p.H125Y | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
CDKL1 | SNV | Missense_Mutation | novel | c.759N>C | p.Lys253Asn | p.K253N | Q00532 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | novel | c.673A>T | p.Arg225Trp | p.R225W | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | novel | c.46N>C | p.Tyr16His | p.Y16H | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GJ-A9DB-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | c.50N>T | p.Gly17Val | p.G17V | Q00532 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDKL1 | SNV | Missense_Mutation | rs779951870 | c.1061N>A | p.Arg354His | p.R354H | Q00532 | protein_coding | tolerated_low_confidence(1) | benign(0.005) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8814 | CDKL1 | TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565840 |
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