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Gene: CDC42EP4 |
Gene summary for CDC42EP4 |
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Gene information | Species | Human | Gene symbol | CDC42EP4 | Gene ID | 23580 |
Gene name | CDC42 effector protein 4 | |
Gene Alias | BORG4 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B2R6D8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23580 | CDC42EP4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.45e-08 | 5.27e-01 | -0.1808 |
23580 | CDC42EP4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.96e-06 | 4.91e-01 | -0.0811 |
23580 | CDC42EP4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.82e-12 | 4.89e-01 | -0.1954 |
23580 | CDC42EP4 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.27e-03 | 7.71e-01 | -0.2602 |
23580 | CDC42EP4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.80e-02 | 6.41e-01 | -0.2196 |
23580 | CDC42EP4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.07e-02 | 4.39e-01 | -0.1207 |
23580 | CDC42EP4 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.28e-02 | 2.74e-01 | -0.1526 |
23580 | CDC42EP4 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.18e-15 | 3.90e-01 | -0.1464 |
23580 | CDC42EP4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.87e-09 | 2.92e-01 | -0.1001 |
23580 | CDC42EP4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.69e-07 | 5.95e-01 | -0.059 |
23580 | CDC42EP4 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.02e-06 | 5.50e-01 | -0.0842 |
23580 | CDC42EP4 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.91e-03 | 2.97e-01 | 0.096 |
23580 | CDC42EP4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.14e-08 | 2.72e-01 | 0.0674 |
23580 | CDC42EP4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.53e-05 | 2.31e-01 | 0.294 |
23580 | CDC42EP4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.04e-02 | 8.67e-01 | 0.3487 |
23580 | CDC42EP4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.19e-07 | 2.76e-01 | 0.281 |
23580 | CDC42EP4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.72e-10 | 3.41e-01 | 0.3859 |
23580 | CDC42EP4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.46e-04 | 1.93e-01 | 0.3005 |
23580 | CDC42EP4 | LZE5T | Human | Esophagus | ESCC | 4.74e-05 | 2.07e-01 | 0.0514 |
23580 | CDC42EP4 | LZE7T | Human | Esophagus | ESCC | 2.05e-07 | 3.63e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC42EP4 | SNV | Missense_Mutation | c.229A>G | p.Ser77Gly | p.S77G | Q9H3Q1 | protein_coding | tolerated(1) | benign(0.013) | TCGA-66-2781-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDC42EP4 | SNV | Missense_Mutation | novel | c.457N>T | p.Gly153Cys | p.G153C | Q9H3Q1 | protein_coding | deleterious(0.04) | benign(0.206) | TCGA-98-7454-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDC42EP4 | deletion | Frame_Shift_Del | novel | c.835_836delCA | p.His279CysfsTer5 | p.H279Cfs*5 | Q9H3Q1 | protein_coding | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CDC42EP4 | SNV | Missense_Mutation | novel | c.272N>T | p.Ser91Leu | p.S91L | Q9H3Q1 | protein_coding | deleterious(0.03) | probably_damaging(0.974) | TCGA-CN-4739-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
CDC42EP4 | SNV | Missense_Mutation | novel | c.527A>G | p.Asp176Gly | p.D176G | Q9H3Q1 | protein_coding | tolerated(0.18) | possibly_damaging(0.588) | TCGA-CV-5979-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42EP4 | SNV | Missense_Mutation | rs185165304 | c.199N>A | p.Glu67Lys | p.E67K | Q9H3Q1 | protein_coding | tolerated(0.31) | benign(0.01) | TCGA-HD-A633-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDC42EP4 | deletion | Frame_Shift_Del | novel | c.706delG | p.Glu236ArgfsTer146 | p.E236Rfs*146 | Q9H3Q1 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CDC42EP4 | SNV | Missense_Mutation | c.890N>A | p.Arg297His | p.R297H | Q9H3Q1 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDC42EP4 | SNV | Missense_Mutation | c.587N>A | p.Ala196Asp | p.A196D | Q9H3Q1 | protein_coding | tolerated(0.18) | benign(0.055) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
CDC42EP4 | SNV | Missense_Mutation | c.146N>T | p.Asp49Val | p.D49V | Q9H3Q1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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