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Gene: CD47 |
Gene summary for CD47 |
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Gene information | Species | Human | Gene symbol | CD47 | Gene ID | 961 |
Gene name | CD47 molecule | |
Gene Alias | IAP | |
Cytomap | 3q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q08722 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
961 | CD47 | GSM4909286 | Human | Breast | IDC | 3.35e-09 | -3.02e-01 | 0.1081 |
961 | CD47 | GSM4909287 | Human | Breast | IDC | 2.46e-08 | -4.43e-01 | 0.2057 |
961 | CD47 | GSM4909290 | Human | Breast | IDC | 8.36e-03 | -3.14e-01 | 0.2096 |
961 | CD47 | GSM4909291 | Human | Breast | IDC | 5.05e-03 | -3.77e-01 | 0.1753 |
961 | CD47 | GSM4909293 | Human | Breast | IDC | 2.14e-08 | -4.28e-01 | 0.1581 |
961 | CD47 | GSM4909294 | Human | Breast | IDC | 2.26e-19 | -5.63e-01 | 0.2022 |
961 | CD47 | GSM4909296 | Human | Breast | IDC | 5.38e-22 | -5.48e-01 | 0.1524 |
961 | CD47 | GSM4909297 | Human | Breast | IDC | 6.74e-17 | -3.44e-01 | 0.1517 |
961 | CD47 | GSM4909298 | Human | Breast | IDC | 8.09e-03 | -1.94e-01 | 0.1551 |
961 | CD47 | GSM4909301 | Human | Breast | IDC | 2.19e-20 | -5.49e-01 | 0.1577 |
961 | CD47 | GSM4909302 | Human | Breast | IDC | 3.77e-04 | -3.60e-01 | 0.1545 |
961 | CD47 | GSM4909304 | Human | Breast | IDC | 9.52e-04 | -3.57e-01 | 0.1636 |
961 | CD47 | GSM4909306 | Human | Breast | IDC | 1.94e-07 | -3.84e-01 | 0.1564 |
961 | CD47 | GSM4909307 | Human | Breast | IDC | 3.35e-19 | -5.68e-01 | 0.1569 |
961 | CD47 | GSM4909308 | Human | Breast | IDC | 4.65e-07 | -4.30e-01 | 0.158 |
961 | CD47 | GSM4909309 | Human | Breast | IDC | 1.16e-02 | -3.31e-01 | 0.0483 |
961 | CD47 | GSM4909311 | Human | Breast | IDC | 1.82e-38 | -6.43e-01 | 0.1534 |
961 | CD47 | GSM4909312 | Human | Breast | IDC | 1.37e-16 | -4.84e-01 | 0.1552 |
961 | CD47 | GSM4909313 | Human | Breast | IDC | 9.95e-04 | -3.50e-01 | 0.0391 |
961 | CD47 | GSM4909317 | Human | Breast | IDC | 9.95e-03 | -2.55e-01 | 0.1355 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00507293 | Breast | Precancer | positive regulation of inflammatory response | 23/1080 | 142/18723 | 6.51e-06 | 1.81e-04 | 23 |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00508707 | Breast | Precancer | positive regulation of T cell activation | 29/1080 | 216/18723 | 1.94e-05 | 4.58e-04 | 29 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:00321034 | Breast | Precancer | positive regulation of response to external stimulus | 46/1080 | 427/18723 | 3.41e-05 | 7.40e-04 | 46 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:19030396 | Breast | Precancer | positive regulation of leukocyte cell-cell adhesion | 30/1080 | 239/18723 | 5.13e-05 | 1.07e-03 | 30 |
GO:00313493 | Breast | Precancer | positive regulation of defense response | 33/1080 | 278/18723 | 6.79e-05 | 1.36e-03 | 33 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00508637 | Breast | Precancer | regulation of T cell activation | 37/1080 | 329/18723 | 8.04e-05 | 1.56e-03 | 37 |
GO:00224098 | Breast | Precancer | positive regulation of cell-cell adhesion | 33/1080 | 284/18723 | 1.03e-04 | 1.89e-03 | 33 |
GO:00071597 | Breast | Precancer | leukocyte cell-cell adhesion | 40/1080 | 371/18723 | 1.07e-04 | 1.94e-03 | 40 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00224079 | Breast | Precancer | regulation of cell-cell adhesion | 45/1080 | 448/18723 | 2.12e-04 | 3.30e-03 | 45 |
GO:19030377 | Breast | Precancer | regulation of leukocyte cell-cell adhesion | 36/1080 | 336/18723 | 2.61e-04 | 3.84e-03 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451211 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa045125 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
hsa0451212 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS3 | CD47 | THBS3_CD47 | THBS | Breast | DCIS |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
COMP | CD47 | COMP_CD47 | THBS | Breast | IDC |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | CC |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | CC |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD47 | SNV | Missense_Mutation | novel | c.272N>C | p.Leu91Ser | p.L91S | Q08722 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | novel | c.533N>A | p.Ala178Asp | p.A178D | Q08722 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | novel | c.799C>T | p.His267Tyr | p.H267Y | Q08722 | protein_coding | tolerated(0.1) | benign(0.033) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CD47 | insertion | In_Frame_Ins | novel | c.63_64insAAAAAGTGGCAGGTTCTACTGTAC | p.Leu21_Phe22insLysLysTrpGlnValLeuLeuTyr | p.L21_F22insKKWQVLLY | Q08722 | protein_coding | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CD47 | SNV | Missense_Mutation | rs867558279 | c.394N>T | p.Arg132Cys | p.R132C | Q08722 | protein_coding | deleterious(0.02) | probably_damaging(0.918) | TCGA-2Y-A9HA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CD47 | SNV | Missense_Mutation | c.125N>G | p.Phe42Cys | p.F42C | Q08722 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-DD-A118-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CD47 | SNV | Missense_Mutation | c.190N>C | p.Asp64His | p.D64H | Q08722 | protein_coding | tolerated(0.22) | benign(0.423) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CD47 | SNV | Missense_Mutation | rs753024870 | c.301N>T | p.Asp101Tyr | p.D101Y | Q08722 | protein_coding | deleterious(0.01) | possibly_damaging(0.769) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | novel | c.290N>T | p.Ser97Phe | p.S97F | Q08722 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CD47 | SNV | Missense_Mutation | c.619N>T | p.Ala207Ser | p.A207S | Q08722 | protein_coding | tolerated(0.53) | benign(0.166) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ABT-510 | ABT-510 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ALX148 | ALX-148 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | TTI-621 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | CC-90002 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Hu5F9-G4 | MAGROLIMAB |
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