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Gene: CCNDBP1 |
Gene summary for CCNDBP1 |
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Gene information | Species | Human | Gene symbol | CCNDBP1 | Gene ID | 23582 |
Gene name | cyclin D1 binding protein 1 | |
Gene Alias | DIP1 | |
Cytomap | 15q15.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | O95273 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23582 | CCNDBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.59e-05 | 3.55e-01 | -0.0811 |
23582 | CCNDBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.32e-02 | 2.48e-01 | -0.1088 |
23582 | CCNDBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.33e-12 | 3.70e-01 | -0.1954 |
23582 | CCNDBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.03e-06 | 7.71e-01 | -0.2602 |
23582 | CCNDBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.64e-03 | 1.94e-01 | -0.1464 |
23582 | CCNDBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.16e-05 | 2.63e-01 | 0.096 |
23582 | CCNDBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.75e-03 | 3.74e-01 | 0.0131 |
23582 | CCNDBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.27e-02 | 1.74e-01 | 0.0674 |
23582 | CCNDBP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.14e-03 | 2.65e-01 | 0.0588 |
23582 | CCNDBP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.74e-10 | 3.16e-01 | 0.294 |
23582 | CCNDBP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.43e-07 | 1.18e+00 | 0.3487 |
23582 | CCNDBP1 | LZE2T | Human | Esophagus | ESCC | 3.12e-06 | 2.97e-01 | 0.082 |
23582 | CCNDBP1 | LZE4T | Human | Esophagus | ESCC | 2.98e-14 | 5.41e-01 | 0.0811 |
23582 | CCNDBP1 | LZE5T | Human | Esophagus | ESCC | 3.49e-05 | 1.12e-01 | 0.0514 |
23582 | CCNDBP1 | LZE7T | Human | Esophagus | ESCC | 2.50e-05 | 5.30e-01 | 0.0667 |
23582 | CCNDBP1 | LZE8T | Human | Esophagus | ESCC | 4.97e-13 | 2.84e-01 | 0.067 |
23582 | CCNDBP1 | LZE20T | Human | Esophagus | ESCC | 9.37e-08 | 2.12e-01 | 0.0662 |
23582 | CCNDBP1 | LZE22D1 | Human | Esophagus | HGIN | 4.04e-06 | 1.40e-01 | 0.0595 |
23582 | CCNDBP1 | LZE22T | Human | Esophagus | ESCC | 3.35e-02 | 4.61e-01 | 0.068 |
23582 | CCNDBP1 | LZE24T | Human | Esophagus | ESCC | 5.55e-23 | 7.75e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCNDBP1 | SNV | Missense_Mutation | c.661G>T | p.Asp221Tyr | p.D221Y | O95273 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CCNDBP1 | SNV | Missense_Mutation | c.826N>A | p.Asp276Asn | p.D276N | O95273 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CCNDBP1 | SNV | Missense_Mutation | rs373733597 | c.776N>A | p.Arg259Gln | p.R259Q | O95273 | protein_coding | tolerated(0.32) | probably_damaging(0.997) | TCGA-69-8255-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCNDBP1 | SNV | Missense_Mutation | rs767075145 | c.203N>T | p.Thr68Met | p.T68M | O95273 | protein_coding | deleterious(0.01) | benign(0.311) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCNDBP1 | SNV | Missense_Mutation | novel | c.171T>G | p.Asn57Lys | p.N57K | O95273 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-CH-5738-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
CCNDBP1 | SNV | Missense_Mutation | c.430N>A | p.Pro144Thr | p.P144T | O95273 | protein_coding | tolerated(1) | benign(0.005) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
CCNDBP1 | SNV | Missense_Mutation | novel | c.796N>T | p.Gly266Trp | p.G266W | O95273 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
CCNDBP1 | SNV | Missense_Mutation | novel | c.868N>T | p.Asp290Tyr | p.D290Y | O95273 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCNDBP1 | SNV | Missense_Mutation | novel | c.615N>T | p.Leu205Phe | p.L205F | O95273 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-HU-A4H5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | doxifluridine | SD |
CCNDBP1 | insertion | Frame_Shift_Ins | novel | c.463_464insGCATCAC | p.Val155GlyfsTer17 | p.V155Gfs*17 | O95273 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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